... 2009 Gerontology 1994;40(suppl 2): 10-15 Seikoh Horiuchi NorieAraki Department of Biochemistry, Kumamoto University School of Medicine, Kumamoto, Japan Advanced Glycation End Products of the Maillard Reaction and Their Relation to Aging Key Words Advanced glycation end product Maillard reaction...

...-dependent mechanism, was shown later to be attributed to the Maillard reaction, the non-enzymatic glycosylation of protein (and nucleotide bases) amino groups followed by evolution of the reaction to advanced glycation end products (AGEs) involved in a number of harmful reactions. Many of these reactions...

... biosynthesis; (2) postsynthetic modifications of extracellular matrix, and (3) modifications of cell-matrix interactions. Examples are discussed for all three aspects of tissue aging, with special emphasis on the role of epigenetic reactions. These reactions include the Maillard reaction, uncontrolled...