..., lifestyle conducted throughout life, environmental conditions, as well as dietary aspects, among others, all together modulating precise pathways linked to aging, making longevity a multidimensional event. Summary: Compelling evidence support the concept that nutritional determinants have major impact...

... level on health and longevity, the members of this inter-academic group propose specific educational actions at three levels: (1) teachers and health professionals, (2) parents, (3) the public, emphasizing that these crucial actions can only be carried out with the unfailing support of state...

... to in the content or advertisements. Microbiota Aging Inflammaging Longevity Human health Intestinal microbiota, defined as microorganisms that live in the gastrointestinal tract of humans and animals, includes symbiotic bacteria that affect the health and coevolution of humans [1]. An increasing...

...Timothy A. Donlon; Randi Chen; Kamal H. Masaki; Bradley J. Willcox; Brian J. Morris Introduction: Genetic variation in the phosphatidylinositol 3-kinase reregulatory subunit 1 gene ( PIK3R1 ) is associated with longevity. Objective: The aim of the study was to determine whether cardiovascular...

...Stacy L. Andersen; Mengtian Du; Stephanie Cosentino; Nicole Schupf; Andrea L. Rosso; Thomas T. Perls; Paola Sebastiani; the Long Life Family Study Introduction: Cross-sectional analyses have associated familial longevity with better cognitive function and lower risk of cognitive impairment...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Human Lifespan Zugzwang Longevity Lifespan is one of the most variable life history traits in the animal...

... for their longevity and expect to die earlier when transitioning into informal caregiving. Thus, supportive interventions for informal caregivers, particularly employed and female informal caregivers, are recommended. l.zwar@uke.de 20 08 2020 20 12 2020 17 3 2021 © 2021 S. Karger AG...

...-related changes Aging Exponential aging Healthy aging Lifestyle Linear aging Longevity Quality of life The dream of life eternal is one that has beguiled humanity since antiquity. Thanks to advances in medicine and science, for the first time in history, we may seemingly grasp...

...Silvia Marchionni; Christian Sell; Antonello Lorenzini Across species, development and longevity are tightly linked. We discuss the relevant literature and suggest that the root for this stringent relationship is the rate of development. The basis for the relationship between rate of development...

.... 2019 Rejuvenation Longevity Health span Metformin Fisetin Confronted with the task to write a review on “metformin and aging,” it was decided to extract information from the most recent literature relevant to humans, focusing on planned or ongoing clinical trials. Mechanisms of action...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Longevity Depression Reverse causation Worthwhile life Well-being...

...Neil Charness Successful longevity is achieved when individuals can continue to plan, pursue, and reach their goals across the life-span. However, normative age-related impairments can make goal attainment more difficult, unless there are interventions to mitigate such changes. Behavioral...

...Leonid A. Gavrilov; Natalia S. Gavrilova There is great interest among gerontologists, demographers, and actuaries in the question concerning the limits to human longevity. Attempts at getting answers to this important question have stimulated many studies on late-life mortality trajectories, often...

... and autonomy – all of which promote longevity. Methods: To better understand potential opportunities and challenges associated with interior design and “future homes” that may promote well-being, aging in place, and independent living in older adults, the authors reviewed relevant literature and included...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Frail elderly Functional decline International comparison Longevity...

.... This highlights the importance of considering biological or functional measures of aging. Studies using model organisms indicate that age-related gut dysbiosis may contribute to unhealthy aging and reduced longevity. The gut microbiome depends on the host nutrient signaling pathways for its beneficial effects...

... the potential to affect the health span and life span of offspring. Key Findings: Various maternal factors, such as environmental toxicant exposure, diet, stress, exercise, age at conception, and longevity have the potential to influence age-associated diseases such as cardiovascular disease, obesity, diabetes...

... lifespan extension programs can be distinguished genetically. It will now be critical to tease apart these programs, because each may involve different longevity-promoting mechanisms that may be relevant to higher organisms. A recent analysis of organismal “healthspan” has questioned the value of C...

...Leonid A. Gavrilov; Vyacheslav N. Krut'ko; Natalia S. Gavrilova Recent scientific publications suggest that human longevity records stopped increasing. Our finding that the mortality of centenarians has not decreased noticeably in recent decades (despite a significant mortality decline in younger...

... with surgery. Extended periods of DR, lasting months to years, are required for optimal longevity benefits in rodents, but short-term dietary preconditioning (less than 1 week) remarkably protects from acute injury. Here, we discuss recent advances in our understanding of the mechanistic basis of short-term DR...