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Keywords: Lipofuscin
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Journal Articles
Journal: Gerontology
Gerontology (2015) 62 (1): 47–57.
Published Online: 10 July 2015
... in zebrafish. Methods: We tested zebrafish of different ages in a color discrimination paradigm for associative learning and in a hole board task for spatial learning abilities. Afterwards, we determined the levels of oxidized lipids and proteins as well as the amount of lipofuscin in the learning-relevant...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 283–296.
Published Online: 15 April 2009
... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Aging Lipofuscin Bovine Muscle brain. LIPOFUSCIN IN BOVINE MUSCLE AND BRAIN: A MODEL FOR STUDYING AGE PIGMENT R D Jolly , B V Douglas', P M Davcy* and J E Roirib...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 229–238.
Published Online: 15 April 2009
... to move; giving a stress to the animal. The cerebella from the stressed groups rats were removed after the experiment and were processed for fluorescent microscopical, histochemical and fluorimetric study of lipofuscin. The lipofuscin content in the Purkinje neurons was compared with that of the control...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 29–38.
Published Online: 15 April 2009
... to oxidative stress (as is typical for age-related lipofuscin pigment). Under oxidative stress, the cytoplasm in normal cells showed a tendency foward increased levels of fluorescent products of protein or lipid peroxidation, which was opposite from the response of tumor cells. In the present paper a novel...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 173–186.
Published Online: 15 April 2009
... the relationship between lipofuscin (LF) accumulation and the aging process by examining the effect of lifelong CR on LF accumulation in brain cells. Specifically, 1) we include age groups of CR (CRl ≡ 90 kcal/wk and CR2 ≡ 58 kcal/wk) and ad libidum fed (AL; ∼120 kcal/wk) mice including groups at maximum lifespan...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 69–80.
Published Online: 15 April 2009
...Masatoshi Nakano; Fadil Oenzil; Toshiaki Mizuno; Shunji Gotoh Lipofuscin is the end-product of intracellular lipid peroxidation and the accumulation results from the cellular metabolism during aging (life stage). We suggested that the accumulation of cardiac lipofuscin was dependent on the specific...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 1–14.
Published Online: 15 April 2009
...K. Klikugawa; M. Beppu; A. Sato Yellow fluorescent lipofuscin deposited in rat tissues was extracted in an aqueous solution. Yellow fluorescence with fluorescence maxima at 400/615-620 nm was detected in the aqueous extracts of brain and kidney of older rats. Purification and characterization...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 201–212.
Published Online: 15 April 2009
... slowly, in the intralysomal accumulation of lipofuscin, or age-pigment. Native lipofuscin shows orange-red autofluorescence when exposed to blue light. The loss of energy resulting from the conversion of excitatory blue light into emitted orange-red light may induce photo-oxidative reactions. We exposed...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 305–318.
Published Online: 15 April 2009
... in the heart and skeletal muscle and infiltrations by lipidic substances. The ultrastructure of some lipidic droplets was analogous to those of ceroid and lipofuscin. Peroxisomes were frequent in degenerating hepatocytes. In order to elucidate the lysosomal involvement in the residual formation, light...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 213–228.
Published Online: 15 April 2009
... of lipofuscin revealed that PM caused an increase in lipofuscin accumulation in the Purkinje neurons. A similar study on the Purkinje neurons of rats belonging to various age groups i.e. 6, 9 and 15 months, showed an increase in lipofuscin accumulation with age. Further the increase in lipofuscinosis in ageing...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 319–326.
Published Online: 15 April 2009
...A. Terman To gain an understanding of the mechanisms of lipofuscin (LF) accumulation in aging cells we studied both the formation and the elimination of autophagic vacuoles (AV) in hepatocytes of adult (5–6 months) and old (20–21 months) CBA male mice. For the evaluation of AV formation we...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 95–108.
Published Online: 15 April 2009
...T. von Zglinicki; E. Nilsson; W.D. Döcke; U.T. Brunk Lipofuscin accumulates in postmitotic cells. In human fibroblasts, accumulation of lipoftiscin as measured by cellular autofluorescence is exponential at first, but stops at a certain level. At the same time, cell death starts to decrease cell...
Journal Articles
Journal: Gerontology
Gerontology (1994) 40 (2-4): 113–132.
Published Online: 14 April 2009
... in favour of the occurrence of senescence in fishes have been derived from studies in species showing gradual senescence. Age-related increases in mortality rate, accumulation of lipofuscin, lipid peroxidation, collagen cross-linking and decreases in growth rate, reproductive capacity and protein...
Journal Articles
Journal: Gerontology
Gerontology (1988) 34 (5-6): 250–256.
Published Online: 07 April 2009
...Daniela Amenta; Fabio Ferrante; Flavio Franch; Francesco Amenta The effects of ageing and of 6 months of Hydergine® treatment on lipofuscin deposition within the cytoplasm of pyramidal neurons of rat prefrontal cortex, hippocampus (fields CA 1 and CA 3 ) and of Purkinje neurons were assessed...
Journal Articles
Journal: Gerontology
Gerontology (1980) 26 (4): 206–216.
Published Online: 06 April 2009
... microscopic evaluation indicated that following hypophysectomy there was a significant loss of lipid droplets, no change in the frequency of light and dark pinealocytes or cytoplasmic dense bodies (probably lipofuscin), a trend towards increased granular deposits between cells, no change in the number...
Journal Articles
Journal: Gerontology
Gerontology (1978) 24 (Suppl. 1): 66–70.
Published Online: 03 April 2009
...K. Nandy; F.H. Schneider C1300 mouse neuroblastoma cells gradually accumulate lipofuscin-like pigment when they are maintained in culture. Pigment was demonstrated by positive staining for acid phosphatase and with periodic acid-Schiff stain. Pigment formation in cells was reduced by exposure...