... Geroprotector Life span Nursing homes Aging Worldwide, healthcare systems are increasingly confronted with aging populations. Hence, the search for geroprotectors, that is, drugs that target the root cause of aging and decrease all-cause mortality, gains in importance. Drug repurposing is herein...

..., memory, and behavioral flexibility more clearly. Taken together, an evolutionary developmental psychology perspective that combines life span psychology with evolutionary biology appears to be a promising avenue for investigations of age-related changes in motivation and cognition. jfischer@dpz.eu...

... in the mean life span are observed between the lines. Yet the conditions in which these measurements were done are highly questionable. More fundamentally, using these data, the analysis of the selection process is impossible and conclusions about the determinism of life span are debatable. 8 09 1995...

...Avan Aihie Sayer; Cyrus Cooper Diet restriction is a well-recognised method of slowing aging and prolonging life span in animals. However, previous studies of this have tended to start after weaning and the effects of prenatal or early postnatal diet restriction have rarely been considered. Here we...

...R. Kakkar; J.S. Bains; S.P. Sharma Zaprionus paravittiger fed with vitamin E supplemented diet (1, 5 and 10 μg/ml) showed an increase in median and maximum life spans. Further increase in concentration accelerated the mortality rate. Females exhibited longer life span as compared to males...

... of longevity. Life span Gene-environment interaction Drosophila melanogaster Genetics of aging Reproduction at late age Selection Experimental Section Gerontology 1995;41:69-76 Robert Arkingab Steven Bucka Department of Biological Sciences and Institute of Gerontology, Wayne State University...

..., because line differences in mean longevity are confounded with erratic temporal variations in life span. Using 15,000 flies from selected and control lines developed by Luckinbill and Clare [Heredity 1985;55:9–19], we show here that when lines are tested simultaneously in a carefully controlled...

...S.P. Sharma; Madhvi Sharma; R. Kakkar The median and maximum life spans of both sexes of Zaprionus paravittiger increased with methionine (100 m M ) feeding. It was accompanied by higher catalase and peroxidase enzyme activities. The lipid peroxide level as measured by malondialdehyde content...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Life span Drosophila melanogaster Realized heritability Selection Variations...

...F.A. Lints; M. Bourgois; A. Delalieux; J. Stoll; C.V. Lints A survey of all the papers relating to life span in Drosophila melanogaster published in Experimental Gerontology from its origin in 1964 to 1981 shows that, contrary to a common belief, the mean life span of females exceeds that of males...

...Harold R. Massie; T.R. Williams; V.R. Aiello Dietary cadmium chloride at concentrations of 1 × 10 –– 4 M or greater shorten the life span of Drosophila melanogaster by as much as 74%. The chelator, CDTA, inhibits the normal age-related cadmium accumulation in whole flies and also improves...

...S.K. Garg; S. Mahajan; S.P. Sharma In the bruchid Caryedon serratus , life span of males was longer than that of females. Catalase showed an increasing trend with age in both the sexes but the increase was higher in males. However, an opposite trend was observed for lipid peroxide levels. A rapid...

...°C the fly CL intensity was stronger than at 25°C. Under the condition of the higher temperature, the fly life span was shorter (mean life span = 29 days at 30°C and 63 days at 25°C), and oxygen consumption (3.7 μl/mg·h at 25°C, 4.9 μl/mg·h at 30°C) and the mobility (movement distance = 25 mm/min...

...Hildegard E. Enesco; Alison McTavish; Riccardo Garberi Spontaneous activity level was measured in rotifers of the species Asplanchna brightwelli on each day of their 5-day life span. No correlation was seen in group data between activity level and life span. However, data from individuals showed...

...F.A. Lints A rereading of The Rate of Living [Pearl, University of London Press, London 1928] shows that Pearl’s thoughts about the meaning of inheritance and heredity, about the relations of between and within populations measurements and about the ways in which life span should be measured...

... of both male and female flies. Life span of female flies also decreased with increasing amplitude of temperature of oscillation but that of males increased (compared to that at the mean temperature) at moderate temperature amplitude. Variation of the period of oscillation (from a rhythm of 6 h/6 h up to 2...

...A.C. Economos; F.A. Lints The concept of an inverse relationship between life span of adult Drosophila and their developmental temperature is probably the result of an unwarranted generalization. Rather, in a wild-type laboratory strain the present study revealed a plateau phase...

...Vladimir M. Dilman; Vladimir N. Anisimov The chronic treatment of female C3H/Sn mice with phenformin (2 mg/day) and diphenylhydantoin (2 mg/day) prolonged mean life span by 23 and 25%, respectively, and decreased spontaneous tumour incidence by 4.0 and 2.3 times, respectively. The chronic treatment...

...Donald K. Ingram; Mark A. Reynolds; Charles L. Goodrick Measures of body weight change were calculated and examined in relation to the life span of 68 male and 71 female Wistar rats that were maintained either in wheel-cage units or cages without wheels. The analysis revealed the following: (a) sex...

...Harold R. Massie; Trevor R. Williams; Valerie R. Aiello No significant differences were found in either mitochondrial or total superoxide dismutase activity levels in two different wild-type strains of Drosophila melanogaster whose life spans differed by 40%. The strains used were Oregon R...