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Gerontology (2017) 63 (4): 327–336.
Published Online: 25 January 2017
... Comparative biology Insulin Insulin-like growth factor-1 Energy metabolism Caloric restriction email@example.com 17 06 2016 5 12 2016 25 1 2017 © 2017 S. Karger AG, Basel 2017 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...
Gerontology (1997) 43 (3): 182–200.
Published Online: 15 April 2009
... of metabolic rate. CR accomplishes this by lowering the nutritionally driven level of insulin exposure, which in turn lowers overall growth factor exposure, improves age-declining maintenance of mitochondrial maximal function, and maintains a longer-term favorable balance of the insulimgrowth hormone...
Gerontology (1982) 28 (1): 10–18.
Published Online: 06 April 2009
...Koji Hayashi Insulin and glucagon secretion after glucose load and the hormone-receptor interaction were compared between 6- and 24-month-old Wistar rats. The 24-month-old rats showed a failure to decrease glucagon secretion after glucose load in contrast to 6-month-old rats with a similar degree...
Gerontology (1977) 23 (1): 55–63.
Published Online: 03 April 2009
... patients had impaired carbohydrate tolerance. Mean plasma glucose level at 2 h was 90.4 ± 6.2 mg/l00 ml in the patients with a normal GTT and 148.1 ± 8.9 mg/l00 ml in the patients with a diabetic type GTT. Mean peak insulin level in the nondiabetic group occurred at 1/2 h and was 60.2 ± 10.1 μ U/ml...
Gerontology (2005) 51 (4): 225–230.
Published Online: 15 June 2005
...Antonio Ruiz-Torres; Rosario Lozano; José Melón; Raffaele Carraro Background: It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. Objectives: This study focusses on the pathway by which insulin induces proliferation and mobility...
Gerontology (2003) 49 (2): 86–92.
Published Online: 19 February 2003
... included insulin treatment in the majority of patients (46/53). Results: Diabetic subjects scored significantly lower in all cognitive tests used, while they did not differ from controls in mood status. From t1 to t2 they improved in those tests measuring attention/concentration, and psychomotor speed...
Gerontology (1999) 45 (3): 121–135.
Published Online: 16 April 1999
... status is easily and safely reversible with probable consequences of greatly postponing the decline in overall ‘reserve capacity’ which may also improve insulin: growth hormone balance and result in lower overall growth factor exposure and consequent longer healthy life of a potentially greater magnitude...
Gerontology (1998) 44 (4): 228–231.
Published Online: 17 June 1998
...) and apolipoprotein AI and apolipoprotein B were determined after an overnight fast before and after the 14-day period of rhGH administration. Subcutaneous rhGH administration was physiologically effective, as shown by a threefold increase in insulin-like growth factor-I (from 110.8 ± 8.2 to 355.5 ± 41.6 ng·ml –1 ; p...
Gerontology (1998) 44 (3): 144–148.
Published Online: 18 April 1998
...A. Ruiz-Torres; J. Melón; F.J. Muñoz The process of aging results in an increase in collagen in arterial walls, but the blood levels of insulin-like growth factor 1 (IGF-1) decrease remarkably as adults age. There is an almost simultaneous increase in insulin secretion, particularly in obese...
Gerontology (1998) 44 (3): 149–152.
Published Online: 18 April 1998
...F.J. Muñoz; M. Jiménez; J. Melón; A. Ruiz-Torres We examined the mechanisms by which insulin may be atherogenic during aging. We postulated that an increase in insulin secretion during aging produces growth factor effects on vascular smooth muscle cells (VSMCs), promoting these cells to synthesize...