..., instructions or products referred to in the content or advertisements. Genetic mouse models of extended lifespan Laboratory mice Growth hormone signalling Longevity pathways Ageing Comparative biology Insulin Insulin-like growth factor-1 Energy metabolism Caloric restriction Ageing...

... of metabolic rate. CR accomplishes this by lowering the nutritionally driven level of insulin exposure, which in turn lowers overall growth factor exposure, improves age-declining maintenance of mitochondrial maximal function, and maintains a longer-term favorable balance of the insulimgrowth hormone...

...Koji Hayashi Insulin and glucagon secretion after glucose load and the hormone-receptor interaction were compared between 6- and 24-month-old Wistar rats. The 24-month-old rats showed a failure to decrease glucagon secretion after glucose load in contrast to 6-month-old rats with a similar degree...

... patients had impaired carbohydrate tolerance. Mean plasma glucose level at 2 h was 90.4 ± 6.2 mg/l00 ml in the patients with a normal GTT and 148.1 ± 8.9 mg/l00 ml in the patients with a diabetic type GTT. Mean peak insulin level in the nondiabetic group occurred at 1/2 h and was 60.2 ± 10.1 μ U/ml...

...Antonio Ruiz-Torres; Rosario Lozano; José Melón; Raffaele Carraro Background: It is known that growth factors play a role in ageing and atherogenesis, and insulin develops mitogenic activity in vitro. Objectives: This study focusses on the pathway by which insulin induces proliferation and mobility...

... included insulin treatment in the majority of patients (46/53). Results: Diabetic subjects scored significantly lower in all cognitive tests used, while they did not differ from controls in mood status. From t1 to t2 they improved in those tests measuring attention/concentration, and psychomotor speed...

... status is easily and safely reversible with probable consequences of greatly postponing the decline in overall ‘reserve capacity’ which may also improve insulin: growth hormone balance and result in lower overall growth factor exposure and consequent longer healthy life of a potentially greater magnitude...

...) and apolipoprotein AI and apolipoprotein B were determined after an overnight fast before and after the 14-day period of rhGH administration. Subcutaneous rhGH administration was physiologically effective, as shown by a threefold increase in insulin-like growth factor-I (from 110.8 ± 8.2 to 355.5 ± 41.6 ng·ml –1 ; p...

...A. Ruiz-Torres; J. Melón; F.J. Muñoz The process of aging results in an increase in collagen in arterial walls, but the blood levels of insulin-like growth factor 1 (IGF-1) decrease remarkably as adults age. There is an almost simultaneous increase in insulin secretion, particularly in obese...

...F.J. Muñoz; M. Jiménez; J. Melón; A. Ruiz-Torres We examined the mechanisms by which insulin may be atherogenic during aging. We postulated that an increase in insulin secretion during aging produces growth factor effects on vascular smooth muscle cells (VSMCs), promoting these cells to synthesize...