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Keywords: Immunosenescence
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Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2022) 68 (9): 961–975.
Published Online: 14 January 2022
... senescence Immunosenescence Immunology Immunosenescence, the gradual remodelling of the immune system, is an integral component of the ageing process [1]. Advanced age impairs innate immune responses, contributes to chronic low-grade inflammation (inflammageing), and reduces immunity, increasing...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2020) 66 (2): 114–121.
Published Online: 14 August 2019
... Immunosenescence National Institutes of Health (NIH) 10.13039/100000002 Aging is characterized by low-grade chronic inflammation called inflammaging [ 1 ], which represents a significant risk factor for morbidity and mortality of elderly individuals as it is implicated in the pathogenesis...
Journal Articles
Journal: Gerontology
Gerontology (2019) 65 (5): 505–512.
Published Online: 18 June 2019
... from any ideas, methods, instructions or products referred to in the content or advertisements. Cellular senescence Tumorigenesis Immunosenescence Senolytics National Institutes of Health (NIH) 10.13039/100000002 Most spontaneous human malignancies display an increased...
Journal Articles
Journal: Gerontology
Gerontology (2017) 63 (6): 515–523.
Published Online: 29 July 2017
... the innate and the adaptive system. This process is termed immunosenescence or immune dysregulation and, basically, includes 3 events: a reduction in immune response, an increase in the inflammatory and oxidation background (inflammaging and oxi-inflammaging), and a production of autoantibodies. While...
Journal Articles
Journal: Gerontology
Gerontology (2015) 61 (3): 203–210.
Published Online: 13 November 2014
... the innate and adaptive immune system undergoes characteristic changes, collectively termed immunosenescence. With increasing age hematopoietic stem cells differentiate preferentially into myeloid progenitors at the expense of the lymphoid lineage [ 4 ]. Therefore, the number of innate immune cells...
Journal Articles
Journal: Gerontology
Gerontology (2014) 60 (2): 99–107.
Published Online: 03 December 2013
..., termed immunosenescence, and age-related changes in tissue structure influence the development of these disorders. Common complications are comorbidities, polypharmacy, and adverse effects of drugs. The elderly have difficulty mounting protective immune responses against newly encountered antigens...
Journal Articles
Journal: Gerontology
Gerontology (2013) 59 (3): 230–239.
Published Online: 24 November 2012
... implications of immunological immaturity or immunosenescence and its impact on vaccine immunogenicity and efficacy will be highlighted in this review. Several approaches have been undertaken to promote Th1 responses in neonates and to enhance immune functions in elderly, such as conjugation to carrier proteins...
Journal Articles
Journal: Gerontology
Gerontology (2010) 56 (4): 390–403.
Published Online: 01 April 2010
... cellular lifespan. Therefore, telomere dynamics are critical in preserving immune function and have become a focus for studies of immunosenescence and autoimmunity. In this review, we describe the role of telomeric nucleoproteins in shaping telomere architecture and in suppressing DNA damage responses. We...
Journal Articles
Journal: Gerontology
Gerontology (2010) 57 (1): 28–32.
Published Online: 29 January 2010
.... However, age-related changes dramatically affect both the innate as well as the adaptive immune system – a phenomenon known as immunosenescence. Deficiencies in micronutrients, especially zinc and iron, as well as vitamin D, in the elderly may also contribute to the development of allergies. A further...
Journal Articles
Journal: Gerontology
Gerontology (2010) 56 (5): 449–458.
Published Online: 19 December 2009
..., instructions or products referred to in the content or advertisements. Exercise Immunosenescence Telomeres Immune risk profile Cytomegalovirus Physical activity Clinical Section / Mini-Review Gerontology 2010;56:449 458 DOI: 10.1159/000270905 Received: May 14, 2009 Accepted: May 14, 2009...
Journal Articles
Journal: Gerontology
Gerontology (2009) 55 (5): 491–495.
Published Online: 23 April 2009
... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. CD4+ cells Immunosenescence...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (1993) 39 (1): 19–27.
Published Online: 14 April 2009
... Immunosenescence Experimental Section Gerontology 1993;39:19-27 Zenghua Liao John H. Tu Catherine B. Small Steven M. Schnippet' David L. Rosenstreich Departments of Medicine, and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, N.Y., USA KeyWords Interleukin-1 Aging Immunosenescence...
Journal Articles
Journal: Gerontology
Gerontology (1983) 29 (5): 305–310.
Published Online: 08 April 2009
... and Laboratory o f Experimental Medicine, Centre Hospitalier Universitaire de Montigny-le-Tillcul, Université Libre de Bruxelles, Belgium Key Words. Immunosenescence Immune deficiency Vitamin C Cell-mediated immunity Abstract. Both ageing and vitamin C (VC) deficiency result in immune defect. Since low...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (1984) 30 (5): 279–289.
Published Online: 06 April 2009
... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Immunity Infection Immunosenescence Gerontology 30: 279-289 (1984)
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2009) 55 (2): 179–185.
Published Online: 07 October 2008
.... IgA Immunosenescence Mortality Older people Cancer Clinical Section Gerontology 2009;55:179 185 DOI: 10.1159/000162260 Received: December 21, 2007 Accepted: May 19, 2008 Published online: October 7, 2008 IgA Level Is Associated with Risk for Mortality in an Eighty-Year-Old Population Takehiro...