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Keywords: Human leukocyte antigen
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Journal Articles

Identification of a Risk Allele at SLC41A3 and a Protective Allele HLA-DPB1*02:01 Associated with Sarcopenia in Japanese

Subject Area:
Geriatrics and Gerontology
Motoki Furutani, Tetsuaki Kimura, Koya Fukunaga, Mutsumi Suganuma, Marie Takemura, Yasumoto Matsui, Shosuke Satake, Yukiko Nakano, Taisei Mushiroda, Shumpei Niida, Kouichi Ozaki, Tohru Hosoyama, Daichi Shigemizu
Journal: Gerontology
Gerontology (2025)
https://doi.org/10.1159/000545298
Published Online: 18 March 2025
..., shedding light on its multidimensional pathogenesis [ 9 ]. However, GWASs target mainly common variants, which often have small effect sizes. Whole-genome sequencing (WGS) provides an opportunity to detect rare variants with potentially larger phenotypic effects. The human leukocyte antigen (HLA) system...
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