...Tze Pin Ng; Xin Zhong; Qi Gao; Xinyi Gwee; Denise Qian Ling Chua; Anis Larbi Introduction: The identification of modifiable health span-promoting factors is a public health priority. Objective: To explore the socio-environmental, lifestyle, behavioural, and psychological determinants of a clinical...

... of action are briefly discussed. A detailed analysis of the evidence for metformin to extend the life of model organisms follows. Anti-aging research is a hot – yet not unproblematic – topic, as will be exemplified. Rejuvenation Longevity Health span Metformin Fisetin In addition to GLP...

... and biologic age and to discuss health span along with lifespan. In general, a frail individual will be more susceptible to adverse health outcomes than a healthy, nonfrail individual of the same age. However, the biology and mechanisms of frailty are still unclear. The development of preclinical models...

... by the use of inbred strains or genetic reference populations of mice. Combining the two, a comprehensive picture of the various determinants of ageing and ‘health span' can be studied in detail, and an appreciation of the relevance of results from model organisms to humans is emerging. The interactions...