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Keywords: Gene expression
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Journal Articles
Journal: Gerontology
Gerontology (2023) 69 (11): 1315–1329.
Published Online: 16 September 2023
... the comprehensive spatial imaging in young and aged rat ovary. Fifteen ovarian cell clusters with distinct gene-expression signatures were identified. The gene expression dynamics of granulosa cell clusters revealed three sub-types with sequential developmental stages. Aged ovary showed a significant decrease...
Journal Articles
Journal: Gerontology
Gerontology (2022) 68 (4): 421–430.
Published Online: 16 September 2021
..., instructions or products referred to in the content or advertisements. 2021 Late-onset Alzheimer’s disease CD33 Gene expression Polymorphism Immune system Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neuronal cell death and progressive dementia. It has a large...
Journal Articles
Journal: Gerontology
Gerontology (2020) 66 (3): 275–285.
Published Online: 22 January 2020
... with the improvement of gene expression levels of long-term potentiation. Furthermore, GPC intake may positively influence lipid metabolism. VO 2 and VCO 2 were determined by indirect calorimetry using an indirect calorimeter (ARCO-2000; Arco Systems, Chiba, Japan), as previously described [ 14 ]. Young control...
Journal Articles
Journal: Gerontology
Gerontology (2019) 65 (4): 387–396.
Published Online: 10 April 2019
... and predispose the joint to OA. The aberrant gene expression in aging articular cartilage that is regulated by various epigenetic mechanisms plays an important role in age-related OA pathogenesis. This review begins with an introduction to the current understanding of epigenetic mechanisms, followed...
Journal Articles
Journal: Gerontology
Gerontology (2016) 62 (3): 304–310.
Published Online: 01 March 2016
... shown to affect ribosome biogenesis, mitochondrial gene expression, and hepatic lipid metabolism. Objective: To analyze the effects of age and short-term calorie restriction (SCR) and subsequent refeeding on SIRT7 expression in key metabolic tissues. Methods: Four- and 24-month-old male Wistar rats were...
Journal Articles
Journal: Gerontology
Gerontology (2013) 59 (3): 240–249.
Published Online: 20 December 2012
.... Growth factors Gene expression Cancer Cardiovascular disease The existence of insulin-like growth factors (IGFs) or somatomedins was first predicted by Salmon and Daughaday [ 1 ] in 1957, who proposed that pituitary growth hormone exerted its effects on skeletal growth by using an intermediate...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (1997) 43 (5): 261–267.
Published Online: 15 April 2009
.... Drosophila aging Actin isoforms mRNA changes Gene expression Transcription regulation Housekeeping genes 19 06 1996 6 07 1996 15 4 2009 O onm lolo^ Experimental Section Gerontology 1997;43:261-267 Received: June 19. 1996 Accepted: July 6, 1996 Martin Labuhn Christine Brack...
Journal Articles
Journal: Gerontology
Gerontology (1991) 37 (6): 310–316.
Published Online: 08 April 2009
...G.H. Park; D.E. Buetow Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its...
Journal Articles
Journal: Gerontology
Gerontology (1992) 38 (Suppl. 1): 29–35.
Published Online: 08 April 2009
.... Endothelin-1 Vascular injury Endothelium Gene expression 8 4 2009 Gerontology 1992;38(suppl 1):29 35 Koji Maemura Hiroki Kurihara Toshisuke Morita Yoshio Oh-hashi Yoshio Yazaki Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo. Japan Production of Endothelin-1...
Journal Articles
Journal: Gerontology
Gerontology (1977) 23 (2): 110–126.
Published Online: 03 April 2009
..., instructions or products referred to in the content or advertisements. Electrophoresis Mouse brain Protein levels Gene expression Gerontology 23: 110 126 (1977) Electrophoretic Analysis of Brain Proteins from Young Adult and Aged Mice William J. Vaughan and Melvin Calvin School of Optometry...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2002) 48 (6): 369–373.
Published Online: 18 October 2002
... process. Objective: We have studied age-related changes in gene expression profiles in the rat liver. One of the genes which exhibited clear and consistent increases in expression is characterised. Methods: Analysis of the gene expression profile was carried out using a combination of an optimised form...