... the comprehensive spatial imaging in young and aged rat ovary. Fifteen ovarian cell clusters with distinct gene-expression signatures were identified. The gene expression dynamics of granulosa cell clusters revealed three sub-types with sequential developmental stages. Aged ovary showed a significant decrease...

..., instructions or products referred to in the content or advertisements. 2021 Late-onset Alzheimer’s disease CD33 Gene expression Polymorphism Immune system Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by neuronal cell death and progressive dementia. It has a large...

... with the improvement of gene expression levels of long-term potentiation. Furthermore, GPC intake may positively influence lipid metabolism. 2 07 2019 22 11 2019 22 1 2020 Studies have reported that GPC has several antiaging effects on brain function, i.e., it delays senescence, transthyretin...

... and predispose the joint to OA. The aberrant gene expression in aging articular cartilage that is regulated by various epigenetic mechanisms plays an important role in age-related OA pathogenesis. This review begins with an introduction to the current understanding of epigenetic mechanisms, followed...

... shown to affect ribosome biogenesis, mitochondrial gene expression, and hepatic lipid metabolism. Objective: To analyze the effects of age and short-term calorie restriction (SCR) and subsequent refeeding on SIRT7 expression in key metabolic tissues. Methods: Four- and 24-month-old male Wistar rats were...

... on how IGF2 affects tumour growth and cardiovascular diseases such as atherosclerosis. Thus, further research will be needed to elucidate the impact of IGF2 on key diseases. Growth factors Gene expression Cancer Cardiovascular disease 16 05 2012 5 10 2012 20 12 2012 ©...

...Matthias Mueller; Fabio Andreas Breil; Glenn Lurman; Stephan Klossner; Martin Flück; Rudolf Billeter; Christoph Däpp; Hans Hoppeler Reprogramming of gene expression contributes to structural and functional adaptation of muscle tissue in response to altered use. The aim of this study...

... Accepted: July 6, 1996 Martin Labuhn Christine Brack Department of Cell Biology, Biozentrum, University of Basel, Basel, Switzerland Age-Related Changes in the mRNA Expression of Actin Isoforms in Drosophila melanogaster Key Words Drosophila aging Actin isoforms mRNA changes Gene expression Transcription...

.... Endothelin-1 Vascular injury Endothelium Gene expression Gerontology 1992;38(suppl 1):29 35 Koji Maemura Hiroki Kurihara Toshisuke Morita Yoshio Oh-hashi Yoshio Yazaki Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo. Japan Production of Endothelin-1 in Vascular...

...G.H. Park; D.E. Buetow Insulin-like growth factor IGF-I and IGF-II gene expression was measured for the first time in rat liver, brain and heart during the later stages of life, i.e., young adulthood (6 months) to senescence (25 months). IGF-I mRNA was detected in all three tissues at all ages. Its...

..., instructions or products referred to in the content or advertisements. Electrophoresis Mouse brain Protein levels Gene expression Gerontology 23: 110 126 (1977) Electrophoretic Analysis of Brain Proteins from Young Adult and Aged Mice William J. Vaughan and Melvin Calvin School of Optometry...

...-related changes in mobilization of stored lipid, we studied the effects of fasting on the gene expression of Apos in the liver as well as serum triglyceride (TG) and cholesterol levels in the serum. Methods: Using young (6- to 8-month-old) and old (24- to 28-month-old) fasted and re-fed mice, Northern...

... process. Objective: We have studied age-related changes in gene expression profiles in the rat liver. One of the genes which exhibited clear and consistent increases in expression is characterised. Methods: Analysis of the gene expression profile was carried out using a combination of an optimised form...