..., instructions or products referred to in the content or advertisements. Free radicals Aging Biomarkers Reactive oxygen species Inflammation In recent years, oxidative stress (OS) and inflammatory biomarkers have been postulated to be important factors in the development of age-related diseases...

... of ageing, oxidative stress also plays a central role in various pathological conditions such as neurodegeneration, vascular and metabolic syndromes, as well as tumor formation [ 15,16,17 ]. Specifically, brain ischemia and stroke have been associated with free radical-mediated reactions [ 18...

...S.K. Ghosh; E.B. Ekpo; I.U. Shah; A.J. Girling; C. Jenkins; A.J. Sinclair We have investigated the effect on blood pressure of treatment with vitamin C (an antioxidant and free radical scavenger) in patients with both systolic and essential hypertension. Following a 2-week run-in phase, two age...

...Rachel Perrin; Serge Briançon; Claude Jeandel; Yves Artur; Alain Minn; Francis Penin; Gérard Siest Cu/Zn superoxide dismutase (Cu/Zn SOD), glutathione peroxidase (GPx) and catalase, which are the three main enzymes involved in cellular protection against damage due to oxygen-derived free radicals...

...A.J. Sinclair; A.J. Girling; L. Gray; J. Lunec; A.H. Barnett Abnormalities of both free radical activity and ascorbic acid metabolism have been documented in diabetes, but their biological basis is unclear and their relationship unstudied in any detail. This study was designed to compare changes...

.... Primates Evolution Free radicals Aging 29 09 1982 29 09 1982 8 4 2009 Debate Gerontology 29: 113-120 (1983) © 1983 S. Karger AG, Basel 0304-324X/83/0292-011382.75/0 Superoxide Dismutase, Longevity and Specific Metabolic Rate A Reply Richard G. Cutler Gerontology Research Center...

...., cataract formation, lipofuscin). Such reports are evidence that oxidant damage is one of several factors which contribute to the aging process, and provide at least partial support for the free-radical theory of aging. Studies of age-related changes in the activities, or levels of antioxidant enzymes...

...C. Jeandel; M.B. Nicolas; F. Dubois; F. Nabet-Belleville; F. Penin; G. Cuny Lipid peroxidation products and defenses against free radical damage were determined in serum of 55 patients with senile dementia of the Alzheimer type (SDAT) and compared with values in 24 age-matched healthy control...

...S. Strother Decreased catalase activity is a consistent feature of leaf senescence. Although not as well documented, superoxide dismutase appears generally to decrease during leaf senescence. These changes suggest that free radical levels are likely to be higher in senescing tissues. The hydrogen...

... division may thus be inhibited leading to age-related reduction of mitochondrial numbers, a deficit in energy production with a concomitant decrease in protein synthesis, deterioration of physiological performance, and, therefore, of organismic performance. Mitochondrial DNA Cell aging Free radicals...

... from low antioxidant in the control diet. The relevance of free radicals to ageing is questioned. 12 06 1980 23 06 1980 6 4 2009 © 1981 S. Karger AG, Basel 1981 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... proteolytic degradation, and free radical release. Proteolytic fragments of fibronectin and of elastic fibers were shown to produce noxious effects and to be engaged in vicious circles of autoentertained and self-amplified mechanisms. We studied in particular the role of the elastin-laminin receptor in tissue...