... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2025 Frailty Aging Elderly Biomarkers...

...Pei-Shan Li; Chia Jung Hsieh; Nae-Fang Miao; Chuan-Hsiu Tsai; Chieh-Yu Liu; Hung-Ru Lin; Shu-Fang Vivienne Wu; Jordan Koh Introduction: Frailty poses a significant concern among older adults residing in the community, impacting their health and quality of life. This study investigated...

...Masanori Morikawa; Kenji Harada; Satoshi Kurita; Chiharu Nishijima; Kazuya Fujii; Daisuke Kakita; Yukari Yamashiro; Naoto Takayanagi; Motoki Sudo; Hiroyuki Shimada Introduction: Maximizing the benefits of physical activity (PA) is important to prevent physical frailty for a measure of this public...

...Di Wu; Zhen Guo; Hui Xue; Lijun Fan; Yilan Liao; Linda Nyame; Mengjing Cui; Yong Tian; Zengliang Ruan; Wei Du Introduction: The effects of exposure to particulate matter and frailty, as well as its exposure-response relationship, have not been effectively explored. This study aimed to explore...

...Markus J. Haapanen; Laura Kananen; Tuija M. Mikkola; Juulia Jylhävä; Niko S. Wasenius; Johan G. Eriksson; Mikaela B. von Bonsdorff Introduction: Few studies have investigated the association between frailty and subsequent body composition. Methods: We performed separate linear mixed model analyses...

...Lee Butcher; Jose A. Carnicero; Karine Pérès; Stefania Bandinelli; Francisco Jose García-García; Fernando Rodriguez-Artalejo; Leocadio Rodriguez-Mañas; Jorge D. Erusalimsky Introduction: Frailty is prevalent among older adults with diabetes mellitus. Elevated serum levels of the soluble receptor...

...Kazuhito Oba; Joji Ishikawa; Yoshiaki Tamura; Yasunori Fujita; Masafumi Ito; Ai Iizuka; Yoshinori Fujiwara; Remi Kodera; Kenji Toyoshima; Yuko Chiba; Masashi Tanaka; Atsushi Araki Introduction: Frailty is a crucial health issue among older adults. Growth differentiation factor 15 (GDF15...

...Mutsumi Suganuma; Motoki Furutani; Tohru Hosoyama; Risa Mitsumori; Rei Otsuka; Marie Takemura; Yasumoto Matsui; Yukiko Nakano; Shumpei Niida; Kouichi Ozaki; Shosuke Satake; Daichi Shigemizu Introduction: Although frailty is a geriatric syndrome that is associated with disability, hospitalization...

...Xin Xia; Zhongli Yang; Zhigang Xu; Jingyi Tang; Gongchang Zhang; Birong Dong; Xiaolei Liu Introduction: Although the relationship between the number of teeth and frailty has been extensively studied, the mediating role of nutrition status in the association between the number of teeth and frailty...

... (MCI), its association with cognitive frailty (CF), a comorbidity of both, is unclear. This study aims to examine the association between CF and arterial stiffness in community-dwelling older adults. Methods: A cross-sectional analysis of 511 community-dwelling older adults aged 65 years or older (mean...

... of organ dysfunction scores of both acute conditions (e.g., sequential organ failure assessment [SOFA] score) and chronic health issues (e.g., clinical frailty scale [CFS]). Recent work suggests that increased CFS is associated with a worse outcome in elderly major trauma patients. We aimed to test whether...

... worldwide and typically tends to manifest at an older age. Marked heterogeneity in time-dependent functional decline in older adults results in varying grades of clinically manifest patient fitness or frailty. The biological age-related adaptations that accompany functional decline have been shown...

...Mitsutoshi Oguri; Hideki Ishii; Rin Fujita; Hiroshi Takahashi; Toyoaki Murohara Introduction: We aimed to investigate the prognostic impact of frailty (defined by the Study of Osteoporotic Fracture [SOF] index and the Clinical Frailty Scale [CFS]) in hospitalized patients with acute decompensated...

... to accelerate the evolution of each other by representing a common pathway toward frailty. Objectives: The objective of the study was to investigate the association of the pentagon-copying task with physical and motor performances and with frailty, in a sample of older adults. Method: This observational, cross...

...Ge Bai; Yunzhang Wang; Jonathan K.L. Mak; Malin Ericsson; Sara Hägg; Juulia Jylhävä Introduction: Although frailty is commonly considered as a syndrome of old individuals, recent studies show that it can affect younger adults, too. Whether and how frailty differs in younger adults compared to old...

...Jinhui Zhou; Xinwei Li; Xiang Gao; Yuan Wei; Lihong Ye; Sixin Liu; Jiaming Ye; Yidan Qiu; Xulin Zheng; Chen Chen; Jun Wang; Virginia Byers Kraus; Yuebin Lv; Chen Mao; Xiaoming Shi Introduction: About half of adults aged ≥80 years suffer from frailty. Exercise is considered effective in preventing...

.... Of these, 2,450 (75–79 years: 1,238, 80–84 years: 861, 85–89 years: 351) died over the 15-year study period. Hazard ratios for death in frailty as determined by the t-KCL score were 1.337 (95% confidence interval [CI], 1.162–1.540) for the pre-frail group and 2.012 (95% CI, 1.7756–2.305) for the frail group at 75...

...Danya Pradeep Kumar; Bijan Najafi; Kaveh Laksari; Nima Toosizadeh Introduction: Frailty is a common geriatric syndrome associated with decline in physiological reserve. While several digital biomarkers of daily physical activity (DPA) have been used in frailty assessment, the association between...

..., and frailty indexes with multimorbidity onset and progression and their predictions of multimorbidity-associated mortality risk. Methods: A prospective cohort study (Singapore Longitudinal Aging Study [SLAS]) of 5,089 community-dwelling older adults aged ≥55 years in two waves of recruitment (SLAS-1: March...

...; Dorota Religa; Juulia Jylhävä Introduction: Frailty, a measure of biological aging, has been linked to worse COVID-19 outcomes. However, as the mortality differs across the COVID-19 waves, it is less clear whether a medical record-based electronic frailty index (eFI) that we have previously developed...