... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Axolotl Urodele Regeneration Fibroblasts Aging Rejuvenation Regenerative...

...Lewis C. Mokrasch Cell membranes from progeroid fibroblasts had an elevated Na + , K + ATPase. Ca ++ ATPase and γ-glutamyl transpeptidase were markedly decreased in progeroid fibroblast membranes. 5′-nucleotide phosphatase was unchanged, compared to age- and sex-matched normal fibroblast membranes...

...T. von Zglinicki; E. Nilsson; W.D. Döcke; U.T. Brunk Lipofuscin accumulates in postmitotic cells. In human fibroblasts, accumulation of lipoftiscin as measured by cellular autofluorescence is exponential at first, but stops at a certain level. At the same time, cell death starts to decrease cell...

...K.V.A. Thompson; R. Holliday Fibroblast cultures were established from skin biopsies from 4 male Werner’s syndrome patients, aged 45–50. Several subcultures were obtained from each primary outgrowth and these were passaged to the end of their in vitro lifespan. Their average longevity...

...R. Holliday; K.V.A. Thompson The level of heat-labile glucose-6-phosphate dehydrogenase (G6PD) has been measured in skin fibroblast cultures from premature ageing or DNA repair deficient genetic syndromes. The short in vitro longevity of Werner’s syndrome, progeria, Cockayne’s syndrome, ataxia...

...K.V.A. Thompson; R. Holliday The lifespan of fibroblasts from genetic syndromes with reduced DNA repair or chromosome stability has been measured. Cells from Bloom’s syndrome, Cockayne’s syndrome, Fanconi’s anaemia and 2 out of 3 cases of ataxia telangiectasia had a significantly reduced growth...

... for others and is increased by external events that introduce de novo information. Aging in vitro Genome Fibroblasts 8 08 1979 8 08 1979 6 4 2009 © 1980 S. Karger AG, Basel 1980 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

...Farrel L. Fort; P.A. Cerutti The role of DNA repair in the aging process was studied using fibroblast cultures derived from rats at the beginning (3 weeks) and at the end (2 years) of their potential lifespan. The effect of treatment of the cultures with the DNA-damaging agent, ethylnitrosourea...

...A. Macieira-Coelho; E. Loria The prolongation of the life span of human fibroblasts in vitro by hydrocortisone seems to be associated with its stimulatory action on ribosome synthesis. The sustaining effect of the hormone on the latter remains, after withdrawal of hydrocortisone, for a time which...

...A. Macieira-Coelho; C. Diatloff; E. Malaise Aging in vitro is defined as the progressive growth decline of mass populations of fibroblastlike cells leading to their eventual loss after serial subcultivations. Different species are compared in terms of the doubling potential of their fibroblasts...

... the biosynthesis of proteins, collagen and fibronectin were evaluated in the presence of agonists and antagonists of the receptor on human skin fibroblasts. The biosynthesis of total proteins determined by 3 H-proline incorporation and of fibronectin (by immunoprecipitation) were shown to increase with passage...

...P. Sharma; C.A. Rupar; J.W. Rip The activities of mitochondrial respiratory chain enzymes with and without ascorbate pretreatment were assayed in 10- to 20-week-old cultures of human fibroblasts. Aging was associated with a significant loss of respiratory chain enzyme activities. The presence...