... of collagen and elastin and increased advanced glycation end-products (AGEs) and cross-links. Elastic fibers undergo lysis and disorganization subsequent to their replacement by collagen and other matrix components. These events cause the loss of elasticity and induce stiffening. Conceptual approaches...

...Milena Atanasova; Emiliana Konova; Miglena Georgieva; Anelja Dimitrova; Marion Coquand-Gandit; Gilles Faury; Stephan Baydanoff Background: Antibodies recognizing the elastin precursor tropoelastin (ATEAb) or degradation products α-elastin (AEAb) are found in the serum of healthy human subjects...

...Lupo Andreotti; Alessandro Bussotti; Daniele Cammelli; Elvira Aiello; Salvatore Sampognaro Collagen, elastin and structural glycoproteins were measured in 21 intact lungs taken at postmortem examination after sudden death from subjects aged from 15 to 83. The data were expressed as milligrams per...

... proteolytic degradation, and free radical release. Proteolytic fragments of fibronectin and of elastic fibers were shown to produce noxious effects and to be engaged in vicious circles of autoentertained and self-amplified mechanisms. We studied in particular the role of the elastin-laminin receptor in tissue...