... (SHRs). Tissue monoamine contents in discrete brain areas were quantified after 20 min of cerebral ischemia with or without 30-min recirculation. Cerebral blood flow (CBF) was determined with a hydrogen clearance method in separate experiments. Dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC...

...W. Birkmayer; J.D. Birkmayer Disorders of neurotransmitter balance are observed in Parkinson’s disease, pharmacotoxic psychosis and depression. The dopamine-serotonin ratio is reduced to about 20% in Parkinson and pharmacotoxic patients in the caudate nucleus and in the substantia nigra...

...Arvid Carlsson Reductions of the levels of transmitter substances and of the activities of enzymes involved in their synthesis have been demonstrated in the aging brain. The sensitivity to the aging process varies for different transmitters and brain regions. Dopamine neurons are more age-sensitive...

...V.D. Petkov; V.V. Petkov; S.L. Stancheva In experiments on 2-, 10- and 22-month-old rats it was found that the B max values of dopamine (DA 2 ), serotonin (5-HT 1 ) and enkephalin (Enk) receptors as well as th( 5-HT level in the three brain regions (cortex, striatum and hypothalamus) decreased...

... of substantia nigra dopamine neurons. Studies of striatal dopamine receptors showed that the specific binding of 3 H-spiroperidol was either significantly increased or reduced in the caudate nucleus and putamen of parkin-sonian patients without levodopa therapy. Scatchard analysis showed that there were...

..., in whom L-T did not affect the mental disturbances, amelioration was obtained only by phenothiazines. Theoretical considerations on the role of dopamine in the genesis of visual hallucinations and mental disturbances emphasizes the benefit of L-T administration in this ‘organo-mental’ syndrome. 2 07...