...Lee Butcher; Jose A. Carnicero; Karine Pérès; Stefania Bandinelli; Francisco Jose García-García; Fernando Rodriguez-Artalejo; Leocadio Rodriguez-Mañas; Jorge D. Erusalimsky Introduction: Frailty is prevalent among older adults with diabetes mellitus. Elevated serum levels of the soluble receptor...

..., instructions or products referred to in the content or advertisements. 2024 Proteomics Aging Diabetes Health Physical activity NIH Multimorbidity, the coexistence of multiple chronic illnesses, is a significant challenge for primary health care [ 1 ], often representing long...

... utilization in individuals with diabetes aged 65 years or above. Methods: The Korea National Health Insurance System claims data from January 2006 to May 2013 (pre-intervention) and June 2013 to December 2014 (post-intervention) were used. The treatment group consisted of patients residing in Seocheon...

...Zayed Mohammad Altowerqi; Zainal Abidin bin Zainuddin Introduction: The prevalence of type 2 diabetes (T2D) has increased dramatically in the last decades in developed and developing countries. In this regard, the purpose of this study is to investigate the prevalence of prediabetes and diabetes...

.... There was no genotypic effect on life span for 1,007 subjects with diabetes and 486 with cancer. Conclusion: Our study provides novel insights into the basis for PIK3R1 as a longevity gene. We suggest that the PIK3R1 longevity genotype attenuates mortality risk in at-risk individuals by protection against cellular...

...Ryan T. Crews; Abagayle L. King; Sai V. Yalla; Noah J. Rosenblatt Diabetic foot ulcers (DFU) are a substantial dilemma for geriatric individuals with diabetes. The breakdown in tissue associated with DFU is typically a result of repetitive cycles of physical stress placed on the feet during weight...

... syndrome. Due to their physiological similarity to humans as well as comparable rates of spontaneous obesity and diabetes mellitus, nonhuman primates provide a useful translational model for the human condition. They allow for an in vivo study of disease progression, interaction of comorbidities, and novel...

... Niche Safety Differentiation Synthetic morphology Diabetes Inverse pharmacology Stem cell © 2015 S. Karger AG, Basel 2015 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...

...Gurtej Singh Grewal; Michael Schwenk; Jacqueline Lee-Eng; Saman Parvaneh; Manish Bharara; Robert A. Menzies; Talal K. Talal; David G. Armstrong; Bijan Najafi Background: Individuals with diabetic peripheral neuropathy (DPN) have deficits in sensory and motor skills leading to inadequate...

.... Aging Frailty Skeletal muscle Atrophy Growth and differentiation factor Drug discovery Obesity Diabetes Humans achieve peak skeletal muscle mass in mid-life and then experience a progressive decline that can equal 50% by the ninth decade. The significant loss of skeletal muscle mass...

...Bijan Najafi; Ryan T. Crews; James S. Wrobel Background: Many diabetes-related peripheral neuropathy (DPN) patients also experience postural instability. Objective: This study examined the effect of electrical stimulation therapy on DPN patients' postural control as well as recovery of plantar...

...Sylvia Knapp Diabetes mellitus is one of the most prevalent conditions in the elderly and is associated with considerable morbidity and mortality, mainly from cardiovascular and renal complications. Furthermore, common perception associates diabetes with a generally increased susceptibility...

...David R. Sell; Vincent M. Monnier Arterial stiffening is a progressive, ubiquitous and irreversible aging process that is interwoven with and accelerated by various diseases such as diabetes, atherosclerosis and hypertension. In large arteries, aging is characterized by decreased turnover...

...Takashi Sakurai; Satoshi Iimuro; Atsushi Araki; Hiroyuki Umegaki; Yasuo Ohashi; Koichi Yokono; Hideki Ito Background: Management of metabolic syndrome (MetS) seems to constitute an efficient strategy to attain successful ageing. Although the clinical entity of MetS in patients with diabetes...

...Zoltan Pataky; François R. Herrmann; Delphine Regat; Hubert Vuagnat Background: The prevalence of the at-risk foot in patients with diabetes is high and is increasing with age. The screening of the at-risk foot should be performed in all geriatric patients and on a regular basis. Objective...

... and extended Verzár’s observations. His work on collagen cross-linking by glycation became of paramount importance in recent times because of the rapid increase of diabetes type II, combined with the metabolic syndrome, one of the major pathologies of modern times. 28 02 2006 30 04 2006 20 9...

...M.C. Kronka; I. Watanabe; M.G.O. Lopes; M.C.P. Silva Background: Data associating palatine mucosa, microvascular architecture, aging and diabetes mellitus are few, so the aim of the present study was to examine these conditions structurally and ultrastructurally. Methods: We used 18 female rabbits...

...Kee-Lee Chou; Iris Chi Objective: To investigate the associations between diabetes and disability in three domains and to determine whether the associations are mediated by diabetes-related complications. Design and Methods: A random representative sample of 2,003 non-institutionalized older Hong...

... and even fewer have carried this out in the special subpopulation of frail elderly patients. Objective: The aim of this study was to examine colonic transit time (CTT) in frail elderly patients. We also attempted to compare CTT in diabetics and nondiabetics within this population. Methods: 45 frail elderly...

...C. Pieri; R. Testa; M. Marra; A.R. Bonfigli; S. Manfrini; I. Testa Background: Contradictory results have been reported in the literature concerning the correlation between glycosylated haemoglobin (HbA1c) and peroxidation level in serum of diabetic patients. Objective: To evaluate this correlation...