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Keywords: DNA repair
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Journal Articles
Journal: Gerontology
Gerontology (2016) 62 (3): 296–303.
Published Online: 09 September 2015
.... Nevertheless, the helicase activity appears to be much more important in DNA repair than exonuclease activity. WRN is recruited very rapidly to DSBs, within a few seconds or minutes depending on the experimental conditions [ 13 ]. It then colocalizes with γ-H2AX, a marker for DSBs, and this colocalization...
Journal Articles
Journal: Gerontology
Gerontology (2016) 62 (2): 173–181.
Published Online: 03 July 2015
.... Accelerated cellular senescence Apoptosis Cell cycle Chromosomal passenger complex DNA damage response DNA repair Replicative senescence Mitosis Nuclear export signal Nucleocytoplasmic transport A mitotic cell encounters various challenges throughout its lifespan forcing it either to undergo...
Journal Articles
Journal: Gerontology
Gerontology (2011) 57 (2): 129–136.
Published Online: 07 April 2010
..., instructions or products referred to in the content or advertisements. DNA repair Leaf senescence Meristem Perennials Plants Seed longevity Telomerase Telomeres Experimental Section / Mini-Review Gerontology 2011;57:129 136 DOI: 10.1159/000310174 Received: August 18, 2009 Accepted: January 15...
Journal Articles
Journal: Gerontology
Gerontology (1993) 39 (5): 241–251.
Published Online: 14 April 2009
.... Alzheimer’s disease Alkylation Methyl methanesulphonate N-methyl-N-nitrosourea Lymphocytes DNA repair High performance liquid chromatography Sister chromatid exchange Experim ental Section Gerontology 1993;39:241-251 Simon E. Tobi» Ruth F. Itzhak* a Molecular Neurobiology Laboratory, Department...
Journal Articles
Journal: Gerontology
Gerontology (1991) 37 (4): 193–198.
Published Online: 08 April 2009
... Laboratory, Department of Optometry and Vision Sciences, UMIST, Manchester, UK Key Words. DNA repair Single-strand breaks Alzheimer s disease Abstract. We have studied DNA single-strand breaks (SSB) and their repair, after y-irradiation, in lymphocytes from patients with Alzheimer s disease (AD) and from...
Journal Articles
Journal: Gerontology
Gerontology (1986) 32 (5): 252–260.
Published Online: 07 April 2009
... University. Washington. D.C., USA Key Words. Apurinic/apyrimidinic lesions DNA repair Alkaline elution Aging gene Clonal lifespan Axenic/nonaxenic media Abstract. The accumulation of DNA fragments in aging Paramecium tetraurelia after 15 days (or approximately 60 generations) of clonal growth...
Journal Articles
Journal: Gerontology
Gerontology (1981) 27 (6): 306–312.
Published Online: 06 April 2009
...Farrel L. Fort; P.A. Cerutti The role of DNA repair in the aging process was studied using fibroblast cultures derived from rats at the beginning (3 weeks) and at the end (2 years) of their potential lifespan. The effect of treatment of the cultures with the DNA-damaging agent, ethylnitrosourea...
Journal Articles
Journal: Gerontology
Gerontology (1976) 22 (1-2): 28–55.
Published Online: 03 April 2009
...John B. Little The experimental evidence is reviewed which bears on the theory that aging in mammalian cells may be related to a decline in the efficiency of normal DNA repair processes. Although the data are as yet fragmentary, they do suggest that there is an age-associated decline...