... during aging. Matreotype Proteomics Transcriptomics Lifespan Extracellular matrix Collagen Matrix metalloproteases Homeostasis Cells and tissues are embedded within extracellular matrices (ECMs), which are important for tissue geometry, integrity, and function [ 1 ]. Besides providing...

...Taihao Quan; Gary J. Fisher Human skin is largely composed of a collagen-rich connective tissue, which provides structural and functional support. The collagen-rich connective tissue is produced, organized, and maintained by dermal fibroblasts. During aging, dermal collagen fibrils undergo...

... of collagen and elastin and increased advanced glycation end-products (AGEs) and cross-links. Elastic fibers undergo lysis and disorganization subsequent to their replacement by collagen and other matrix components. These events cause the loss of elasticity and induce stiffening. Conceptual approaches...

...Allen J. Bailey; Jason P. Mansell Research into the aetiology of osteoarthritis has for several decades been concentrated on the destruction of the articular cartilage, the initiating events being believed to be changes in the proteoglycans and subsequently in the supporting collagenous framework...

... of mutated receptors in various cultured cells and analysis using synthetic peptides indicate that two coiled-coil domains, α-helical coiled-coil domain (domain IV) and collagen-like domain (domain V) mediate these functions. Domain IV is essential for the trimerization of MSR and EDTA-resistant adhesion...

...C.J. Rodrigues; A.J. Rodrigues, Jr.; G.M. Bohm Age-related changes of muscle fiber and collagen content of the diaphragm (DIA) and rectus abdominis (RA) muscles were examined in rats aged 1, 4, 8 and 18 months. The cross-sectional areas of all muscle fiber types (I, IIa, IIb) and the amount...

... species of lizards (Calotes versicolor) and snakes (Natrix natrix) showing gradual senescence support the concept of commonalities in ageing phenomena in vertebrates. An age-related increase in the stability of collagen and accumulation of altered enzyme molecules, a decrease in metabolism and response...

... in favour of the occurrence of senescence in fishes have been derived from studies in species showing gradual senescence. Age-related increases in mortality rate, accumulation of lipofuscin, lipid peroxidation, collagen cross-linking and decreases in growth rate, reproductive capacity and protein...

...) continue to grow throughout life and are believed to exhibit very slow or negligible senescence which is unobtrusive. In a few species with gradual senescence, there is some evidence of an increase in mortality rate and a decrease in growth rate with advancing age. Increase in cross-linking of collagen...

...Henrik Christensen; Troels Torp Andreassen; Hans Oxlund The effects of treatment with 2.7 mg biosynthetic human growth hormone (b-hGH; 2.7 mg/kg b.w./day) for 80 days on the biomechanical properties and collagen deposition of the left colon were studied in 27-month-old male rats. The b-hGH-treated...

...Lupo Andreotti; Alessandro Bussotti; Daniele Cammelli; Elvira Aiello; Salvatore Sampognaro Collagen, elastin and structural glycoproteins were measured in 21 intact lungs taken at postmortem examination after sudden death from subjects aged from 15 to 83. The data were expressed as milligrams per...

...Krystyna Olczyk Age-related changes of human intervertebral disk collagen have been investigated. A progressive, age-related accumulation of collagen, both in annulus fibrosus and in nucleus pulposus was found. A decrease in collagen solubility was observed during physiological aging. Up to the 3rd...

... and collagen synthesis, yet the overall wet weight of the corresponding bone decreased. It thus became apparent that the femur of old animals possesses the capacity to respond to enforced training, yet the latter contains elements characteristic of a negative type of adaptation. 7 4 2009 © 1987 S...

...H.N. Behera; B.K. Patnaik Alloxan-decreased percentage solubility level of collagen in bone, skin and tendon following 4 and 28 days of treatment showed an almost complete recovery to normal levels in bone and skin after a 20-day recovery period. Alloxan effect is still maintained in tendon after...

...H.N. Behera; B.K. Patnaik Alloxan diabetes in Swiss mice of both sexes accelerated the ageing of collagen in newly formed cotton pellet granuloma concomitant with its similar effect on dorsal skin. The degree of response of collagen to alloxanization was dependent on the duration of the treatment...

...S. Mohan; E. Radha Age-related studies of collagen in slow, fast and cardiac muscle of the rat indicate that different fractions of collagen as well as total collagen content vary with age and type of muscle. The total collagen level increases by 30% in slow, 40% in fast and 50% in cardiac muscle...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Human cornea Descemet’s membrane Basement membranes Collagen Amino acid analysis Gerontology 26: 217 220 (1980) Age-Related Biochemical Changes in Human Descemet s Membrane1 Ian Freeman, Jean...

...H.N. Behera; B.K. Patnaik Alloxan diabetes in Swiss mice induced decreased levels of percent solubility of collagen in bone, skin and tendon both after 4 days (96 h) and 28 days of treatment. In vitro treatment of tissues with alloxan in physiological saline did not influence the cross-linking...

...Shigeo Shiozawa; Tomoji Tanaka; Tadao Miyahara; Atsushi Murai; Masakuni Kameyama Age-related changes in the reducible cross-links of soluble and insoluble collagens from the human skin and aorta were evaluated. Histidinohydroxymerodesmosine decreased with age up to the fifth decade...

...A. Ruiz-Torres The spectrum of aldimine cross-link bonds of skin collagen is dependent on the localization of the examined material. In correlation to this, there is no synchronous behaviour of cross-linkage in the aging process. The age-dependent decrease of HLNL and the increase of DHLNL...