... Introduction: Centenarians are considered a model of successful aging. Cuba exhibits one of the oldest populations in Latin America with more than two thousand centenarians. Methods: This study aimed to evaluate the immune phenotype of forty-three Cuban centenarians, their clinical characteristics...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Limits to life span Life-history strategy Life expectancy Maximum life span Centenarians Maximum reported age at death...

...Leonid A. Gavrilov; Vyacheslav N. Krut'ko; Natalia S. Gavrilova Recent scientific publications suggest that human longevity records stopped increasing. Our finding that the mortality of centenarians has not decreased noticeably in recent decades (despite a significant mortality decline in younger...

.... 2017 Limits to life span Life-history strategy Life expectancy Maximum life span Centenarians Negligible senescence Dietary restriction Maximum reported age at death In recent centuries, humankind did manage to significantly postpone mortality from such causes as violence, famine...

... of two exceptionally healthy centenarian brothers aged 106 and 109 years who had never been diagnosed with cancer, cardiovascular disease, diabetes, Alzheimer's disease, or major pulmonary disease. Objective: The aim of this study was to gain insight into whether exceptional health and longevity...

... masked by between-family variation. It was also found that male gender of centenarian has a significant positive effect on the survival of adult male biological relatives (brothers and fathers) but not of female relatives. Finally, large gender differences are found in longevity determinants for males...

... modifications seen in an electrocardiogram (ECG) in elders are: prolonged PR and QT intervals, QRS left-axis deviation and microvolt T wave. Several studies have included elderly people, but not long-living elderly and centenarians in particular who represent an increasing part of the population. Objective...

... Infections Centenarians National Institutes of Health (NIH) 10.13039/100000002 Clinical Section / Debate Gerontology 2012;58:221 223 DOI: 10.1159/000329894 Comments on Dietary Restriction, Okinawa Diet and Longevity Natalia S. Gavrilova Leonid A. Gavrilov Center on Aging, NORC...

... of the Georgia Centenarian Study. Objective: To determine whether family history variables predict critical outcome areas such as cognitive functioning, activities of daily living, mental health, and economic dependence. Methods: A total of 318 older adults (236 centenarians and 82 octogenarians) were assessed...

... of this study was to determine how perceptions of health, social provisions, and economics link past satisfaction with life to current feelings of happiness among persons living to 100 years of age and beyond. Methods: A total of 158 centenarians from the Georgia Centenarian Study were included to conduct...

...Caleb E. Finch This review updates developments of the concept of negligible senescence, proposed in Longevity, Senescence, and the Genome in 1990, with new information for turtles, rockfish, and the naked mole-rat. However, centenarians certainly do not show negligible senescence. Negligible...

...Antonella Lisa; Daniela Monti; Claudio Franceschi; Anna Ivana Scovassi Background: Centenarians display a characteristic autoantibody profile, this being the absence of organ-specific autoantibodies and an increase in non-organ-specific autoantibodies without any full-blown autoimmune disease...

...: To determine which are the survival determinants in centenarians using a neural network. Methods: Sample of 110 centenarians living in Rome, mean age 101.6 years (SD = 1.8) with a sex ratio males:females of 1:3. We administered an extensive health interview (lasting 1–2 h) to each subject. The questionnaire...

... and 25 centenarians. Results: Plasma levels of TNF-α increased with increasing age. An increased percentage and number of T lymphocytes from the 81 year olds expressed TNF-α, whereas centenarians did not show this altered TNF-α secretion profile. Conclusion: T cells may contribute to the elevated levels...