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Keywords: Cellular senescence
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Journal Articles
Journal: Gerontology
Gerontology (2024) 70 (1): 7–14.
Published Online: 25 October 2023
... at improving overall skin appearance and health. Summary: As a hallmark of aging, cellular senescence, an essentially irreversible cell cycle arrest with apoptosis resistance and a secretory phenotype, manifests across skin layers by affecting epidermal and dermal cells. Knowledge of skin-specific senescent...
Journal Articles
Journal: Gerontology
Gerontology (2024) 70 (1): 59–75.
Published Online: 12 October 2023
... to in the content or advertisements. 2023 Osteoarthritis Circadian rhythm Age-related changes Cellular senescence Treatment Osteoarthritis (OA) is recognized as an age-related disease and one of the most prevalent joint diseases among the elderly population. According to epidemiological...
Journal Articles
Journal: Gerontology
Gerontology (2022) 68 (9): 961–975.
Published Online: 14 January 2022
... . 2018 ; 87 ( 1 ): 4 – 14 . 5. Muñoz-Espín   D , Serrano   M . Cellular senescence: from physiology to pathology . Nat Rev Mol Cell Biol . 2014 ; 15 ( 7 ): 482 – 96 . 6. Vasileiou   PVS , Evangelou   K , Vlasis   K , Fildisis   G , Panayiotidis   MI , Chronopoulos...
Journal Articles
Journal: Gerontology
Gerontology (2022) 68 (3): 339–352.
Published Online: 23 June 2021
..., which is aimed at improving tissue regeneration and function of the aged body. However, the application of MSC therapy is often unsatisfying in the aged group. One reasonable conjecture for this correlation is that aging microenvironment reduces the number and function of MSCs. Cellular senescence also...
Journal Articles
Journal: Gerontology
Gerontology (2019) 65 (5): 505–512.
Published Online: 18 June 2019
...Luis I. Prieto; Darren J. Baker In response to a variety of cancer-inducing stresses, cells may engage a stable cell cycle arrest mechanism, termed cellular senescence, to suppress the proliferation of preneoplastic cells. Despite this cell intrinsic tumor suppression, senescent cells have also...
Journal Articles
Journal: Gerontology
Gerontology (2018) 64 (3): 229–236.
Published Online: 07 December 2017
...Markus Schosserer; Johannes Grillari; Christian Wolfrum; Marcel Scheideler Aging is a time-related process of functional decline at organelle, cellular, tissue, and organismal level that ultimately limits life. Cellular senescence is a state of permanent growth arrest in response to stress and one...
Journal Articles
Journal: Gerontology
Gerontology (2016) 62 (5): 513–518.
Published Online: 01 April 2016
...-related diseases. Here, we review studies on the role of senescent cells in the skin, with particular emphasis on the age-related mechanisms and phenotypes associated with excessive accumulation of cellular senescence. We discuss the aberrant behavior of senescent cells in aging and how the different...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2014) 60 (3): 197–203.
Published Online: 28 February 2014
...-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing. Progerin accumulation leads to faster cellular senescence, stem cell depletion and the progeroid phenotype. Tissues of mesodermic origin are especially affected by HGPS. HGPS...
Journal Articles
Journal: Gerontology
Gerontology (2004) 50 (6): 420–424.
Published Online: 14 October 2004
... Laboratory, INRCA Research Department, Ancona, Italy Key Words Telomere aging W Cellular senescence W Antiaging strategies W Biomedical research, aging W Regenerative biology W Molecular biology W Strategies, engineered negligible senescence that a common consensus has been raised towards the possible...