... worldwide and typically tends to manifest at an older age. Marked heterogeneity in time-dependent functional decline in older adults results in varying grades of clinically manifest patient fitness or frailty. The biological age-related adaptations that accompany functional decline have been shown...

... healthy longevity can be gained by quantifying the biological aging process and understanding the roles of modifiable lifestyle and environmental factors, and chronic disease conditions. Methods: We developed a biological age (BioAge) index by applying multiple state-of-art machine learning models based...

...Haemi Jee; Byeong Hwan Jeon; Young Hwan Kim; Hong-Kyu Kim; Jaeone Choe; Jaehyun Park; Youngsoo Jin Background: Several biological age (BA) prediction models have been suggested with a variety of biomarkers. Valid models should be able to measure BA in a relatively short time period and predict...

...Xiaojuan Bai; Lulu Han; Qiang Liu; Haiyan Shan; Hongli Lin; Xuefeng Sun; Xiang-mei Chen Background: Although there have been cross-sectional and longitudinal studies examining biological age (BA) with chronological age (CA)-related changes in physical, physiological, biochemical, and hormonal...

...Christopher J. Bulpitt There are many problems in measuring ‘biological’ age rather than chronological age, not least the necessity of demonstrating that this measure has validity in terms of better predicting mortality or morbidity. This review considers nine problems in measuring biological age...

... with ‘lifespan’. The conclusion is that clinical measurements have little value in defining biological age and lifespan. These latter are the outcomes of uncorrected molecular errors which are far removed in time and place from their clinical expressions. 1 01 1995 3 08 1995 15 4 2009 ©...

...Stephen Brown; W.F. Forbes The conditions which must be satisfied by an index of biological age are discussed, and a high correlation with chronological age is shown to be neither a necessary nor a sufficient condition to be satisfied by any such index. 25 07 1975 3 4 2009 © 1976 S...

...Stuart W.S. MacDonald; Roger A. Dixon; Anna-Lisa Cohen; Janine E. Hazlitt Background: Although recent cross-sectional findings indicate that markers of biological age (BA) mediate chronological age (CA) differences in cognitive performance, little is known about their influence on actual cognitive...

...Ronald P. Gruber; Alicia D. Kalamas Background: This study was prompted by a desire to measure human age by a means other than chronological or biological age. The purpose of the study was to use the total lifetime caloric intake in men as an index of aging. Method: The study was carried out...

...Marcel G.M. Olde Rikkert Background: Visual estimation of age can be used as a measure of biological age (BA) and has become useful in predicting life expectancy. Objective: The aim of this study was to quantify the interrater agreement of experienced geriatricians in visual estimation of BA...