... there is an increase in autoimmunity in the elderly, this does not always translate into an increase in autoimmune diseases, which represent an important cause of morbidity and mortality and affect 5-10% of the world population. Each disease involves a specific age group. Generally speaking, most autoimmune diseases...

..., congenital microcephaly and Guillain-Barré syndrome (GBS), which includes a group of acute autoimmune neuropathies generally reported after respiratory or gastrointestinal infectious diseases. Despite being relatively rare, the incidence rate of GBS rises with age, which makes GBS more frequent...

...Bianca K. Itariu; Thomas M. Stulnig Autoimmunity is a well-known pathogenic component in type 1 diabetes (T1DM). The assumption that the pathogenesis of type 2 diabetes (T2DM) also encompasses autoimmune aspects is recognized increasingly, based on the presence of circulating autoantibodies against...

...Antonella Lisa; Daniela Monti; Claudio Franceschi; Anna Ivana Scovassi Background: Centenarians display a characteristic autoantibody profile, this being the absence of organ-specific autoantibodies and an increase in non-organ-specific autoantibodies without any full-blown autoimmune disease...

...Vijendra K. Singh Immune factors such as cellular immunity, autoimmunity, and inflammation may play a pathogenic role in Alzheimer’s disease (AD), a neurodegenerative disorder. Based on immu-nologic dysregulation in many patients, a neuroautoimmunity (NAI) model is proposed which suggested a CD8...

...Howard Fillit; Michael Mulvihill In the very old, there is an increased prevalence of immunologically mediated vascular disease. Vascular heparan sulfate proteoglycan (vHSPG) is a molecule which plays an important structural and functional role in the vasculature. Autoimmunity to vHSPG may play...

...Sherman Fong; Pojen P. Chen; John H. Vaughan; Dennis A. Carson Aging is accompanied by increased prevalence of serum autoantibodies. One commonly detected autoantibody, IgM rheumatoid factor, is also found associated with rheumatoid arthritis and other autoimmune disorders. Much evidence indicates...

...László Urbán; Beáta Bessenyei; Marietta Márka; Imre Semsei Several types of diseases, among others autoimmune illnesses, could be coupled with the general processes of aging. The two-edged sword of immune defense is directed on one side against environmental attacks and on the other against...