...Qunshan Ye; Yimin Li; Cheng Wang; Jingming Zheng; Jing Qiao; Jing Yang; Qin-Li Wan Introduction: The discovery of longevity molecules that delay aging and prolong lifespan has always been a dream of humanity. Sitagliptin phosphate (SIT), an oral dipeptidyl peptidase-4 (DPP-4) inhibitor, is an oral...

...Ligia J. Dominguez; Nicola Veronese; Mario Barbagallo Background: The aging process is complex, comprising various contributing factors influencing late-life conditions and eventual occurrence of chronic diseases that generate high financial and human costs. These factors include genetic proneness...

...Suey S.Y. Yeung; Suk Ling Ma; Xingyan Wang; Yangchao Chen; Stephen Kwok Wing Tsui; Nelson Leung Sang Tang; Jean Woo Introduction: Telomere length (TL) is generally regarded as a biomarker of aging . TL, which is influenced by sociodemographic factors, has been shown to be inversely associated...

... mechanisms to delay age-related impairments and attenuate deficits related to neurodegenerative diseases. However, the chronic effects of these interventions are not well described. Methods: In the current study, global levels of cholinergic, cellular, synaptic, and inflammation-mediating proteins were...

...Klaus Rothermund; Christoph Englert; Denis Gerstorf We define aging as a characteristic deterioration in one (or more) observable attributes of an organism that typically occurs during later life. With this narrow functional definition, we gain the freedom to separate aging from other processes...

...Yipeng Song; Yang S. Liu; Fernanda Talarico; Yanbo Zhang; Jake Hayward; Mengzhe Wang; Eleni Stroulia; Roger A. Dixon; Russell Greiner; Xinmin Li; Andrew Greenshaw; Sui Jie; Bo Cao Introduction: An aging population will bring a pressing challenge for the healthcare system. Insights into promoting...

...Jiali Wu; Yuxin Jiang; Junran Sun; Xiaodong Sun Introduction: Neovascular age-related macular degeneration (NVAMD) is a leading cause of severe vision impairment in the elderly. Aging is one of the most pivotal underlying molecular mechanisms of NVAMD. Methods: In this study, we identified...

... ]. © 2023 The Author(s). Published by S. Karger AG, Basel Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY). Usage, derivative works and distribution are permitted provided that proper credit is given...

...Kim Uittenhove; Daniela S Jopp; Charikleia Lampraki; Kathrin Boerner Introduction: Research on coping in advanced old age is scarce. In the present study, we explored coping patterns in near-centenarians and centenarians, and characteristics associated to using a specific coping pattern. Methods...

... an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty, and cognitive impairment...

...Ajla Hodzic Kuerec; Andrea B. Maier Rapamycin (sirolimus) is an immunosuppressive drug approved by the Food and Drug Administration (FDA). It is also a leading candidate for targeting aging. Rapamycin and its analogs (everolimus, temsirolimus, ridaforolimus) inhibit the mammalian target...

...) or the Activities-specific Balance Confidence (ABC) score. Data were pooled and mean differences (MDs) between exergame and control groups were calculated using a random-effects model. Results: Twenty-seven RCTs were included (1,415 participants, including 63.9% of women, with mean age ranging from 65 to 85.2 years...

... aged 80 years and over, able to walk unaided, with no cognitive or immunological impairment, and with no serious diseases was conducted. Blood samples were collected between 2012 and 2014 during the morning period, and the following tests were conducted: urea, creatinine, hemogram, fasting glucose...

..., for example, risk stratification or monitoring of disease progression or the effectiveness of treatments and interventions, improving clinical practice in myriad ways. In this review, we combine the biomarker discovery concept with geroscience. Geroscience bridges aging research and translation to clinical...

... analysis of the Italian Longitudinal Study on Aging (ILSA) population-based cohort ( n = 5,632, 65–84), frailty status was operationalized according to Fried criteria ( n = 2,457). Weighted prevalence and incidence rates were calculated at each ILSA wave (T0 1992–1993, T1 1995–1996, T2 2000–2001...

... and cognitive factors with gait variability have seldom included middle-aged adults, even though these adults already experienced loss of muscular strength and postural stability. This study aimed a) to examine and compare the trend of gait variability in men and women, across the adult age spectrum, and b...

... for each group to detect a difference of 12 cm H 2 O for maximum inspiratory pressure (MIP), considering a power of 80% and security of 95%. A loss of 30% was estimated to guarantee the sample. Institutionalized elderly women aged between 75 and 95 years were included, who had more than 60 points...

... aging. We determined the degree to which the left atrial function could be distinguished by advanced cardiac magnetic resonance (CMR) imaging in older adults and assessed associations between the left atrial function and the plasma biomarkers related to biological aging and cardiovascular disease [serum...

... Study on Aging (CLSA), a large national study with participants’ ages of 45–85 years at baseline, we sought to identify correlates of SCD and SCD-related worry. Methods: In our primary analysis using a Poisson regression model, associations between biopsychosocial variables and SCD were identified...

...Rebecca L. Krupenevich; Owen N. Beck; Gregory S. Sawicki; Jason R. Franz Older adults walk slower and with a higher metabolic energy expenditure than younger adults. In this review, we explore the hypothesis that age-related declines in Achilles tendon stiffness increase the metabolic cost...