...Shaoyuan Cui; Qi Huang; Tian Li; Wanjun Shen; Xiangmei Chen; Xuefeng Sun Introduction: Renal interstitial fibrosis is an important pathological basis for kidney ageing and the progression of ageing nephropathy. In the present research, we established an aged mouse model of faecal microbiota...

... people” were employed in the search strategy. Studies meeting the following criteria were included: (i) participants had a minimum age ≥60 years, and were free of any neurological, musculoskeletal, and cardiovascular diseases; (ii) an active intervention consisting of footwear, foot orthoses, or insoles...

... is inherently difficult as it often relies on self-report which may be inaccurate. Methods: Archival video recordings of falls that occurred in two long-term residential aged care facilities were initially screened to determine whether the footwear worn at the time (barefoot, socks, slippers/sandals, or shoes...

...) age of 80 (8) years. There were no statistical or clinically meaningful differences between groups (control group – intervention group values) for all variables: utility score = −0.028 (95% CI: −0.071, 0.014; p = 0.18); VAS: −0.03 (95% CI: −0.39 to 0.33; p = 0.86); and capability = −0.021 (95% CI...

... Research at Istanbul Medipol University Hospital with decision number 10/13. The demographic information of the participants is given in Table 1 . There was not any statistically significant difference between age, gender, and blood pressure between the groups ( p > 0.05...

... loss as we age. By contrast, mild traumatic brain injury (mTBI) could accelerate age-related cortical atrophy. The current study sought to examine whether variations in the CRF level modified the association between mTBI history and brain volumetric measures in a sample of older adults. Methods...

...Xue Liang; Wei Sen Zhang; Ya Li Jin; Chao Qiang Jiang; Feng Zhu; Kar Keung Cheng; Tai Hing Lam; Lin Xu Introduction: Ageing process is influenced by multi-dimensional factors collectively. Previous studies examined association of one separate factor with mortality without considering different...

...Paul Doody; Janet M. Lord; Carolyn A. Greig; Anna C. Whittaker The world’s population is ageing, and most older adults experience a later life burdened with disease and disability. Frailty is a multidimensional and dynamic condition characterized by declines in reserve and function across multiple...

...Amanda Veiga Sardeli; Marcelo A. Mori; Janet M. Lord Background: Highly differentiated, senescent lymphocytes are pro-inflammatory and contribute to age-related systemic inflammation, called inflammageing. There are several reports of acute changes in senescent lymphocyte counts post exercise...

... during an 11-year follow-up among men and women aged 55 years. Methods: We used Finnish population-based Health 2000 Survey and its follow-up measurements in 2011. The study population consisted of 1,200 individuals, aged 55–86 years at baseline. Baseline fasting glucose level or use of diabetes...

...Thomas Lung; Pasquale Di Cesare; Lorenz Risch; Urs Nydegger; Martin Risch Youth, working age and the elderly: On a timeline, chronological age (CA) and biological age (BA) may dissociate; nosological entities manifest themselves at different BAs. In determining which disease corresponds to a given...

...Sho Nakakubo; Takehiko Doi; Kota Tsutsumimoto; Satoshi Kurita; Hideaki Ishii; Takao Suzuki; Hiroyuki Shimada Background: The association of sleep habits with “advancing age among older adults” is not fully understood. Objectives: The purpose of the present study was to examine the association...

..., are linked with familial well-being. Objectives: The aim of this study was to investigate whether, among persons with neuropsychiatric symptoms, age-related sensory loss is related to increased emotional distress reported by their family and friends. Methods: The sample comprised 537 participant-informant...

... of whether they are presented in context in an experience-near format. amanda.e.selwood@gmail.com 4 07 2019 10 01 2020 27 3 2020 © 2020 S. Karger AG, Basel 2020 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

... damage repair, mitochondrial homeostasis, and stress responses. Recently, it is gaining more attention in drug discovery as well. As life expectancy keeps rising, more individuals are at risk for developing age-associated diseases. This not only makes a person’s life uncomfortable, but it also places...

...Jiao Li; Xiaodong Cui; Xiaoli Ma; Chen Li; Zhuanhua Wang Background: With the acceleration of aging process in human society, improvements of the physical functionality and life quality in the elderly population are more meaningful than pure longevity. Buckwheat trypsin inhibitor is a low molecular...

... attrition on frailty index trajectories and gaps related to socio-economic status (education) therein among older adults in Europe. Methods: A total of 64,143 observations from 21,044 respondents (50+) from the Survey of Health, Ageing and Retirement in Europe across 12 years of follow-up (2004–2015...

... Jimenez-Mena; José Luis Zamorano Background: Myocardial infarction (MI) patients are increasingly older, and common risk scores include chronological age, but do not consider chronic comorbidity or biological age. Frailty status reflects these variables and may be independently correlated with prognosis...

... to reduced mortality, increased life expectancy and, as such, growth of the older population. Ageing is accompanied by profound morphological and physiological alterations. In particular, the immune system undergoes a complex series of remodeling/restructuring events, involving almost all compartments - both...

...Vian Azzu; Teresa G. Valencak The mouse has rapidly become the mammalian model organism of choice in ageing research due to its relatively short lifespan, the proximity of its genome and physiology to humans, and most importantly due to its genetic pliability and the availability of mutant strains...