... to insulin resistance and the metabolic syndrome. We summarize the effects of age on the adipose tissue (AT), related to the abundance, distribution, cellular composition, endocrine signaling and function of the tissue. The AT is an immunological tissue, with several hallmarks of innate and adaptive immune...

... depots, on the metabolism of white and brown adipose tissue, on the regenerative potential and adipogenic differentiation capacity of preadipocytes, and on alterations in mitochondria and bioenergetics. In conclusion, the aging process is a lifelong, creeping process with gradual decline in (pre...

... evidence suggests that long-lived GH-resistant/deficient mice are protected from white adipose tissue (WAT) dysfunction, including WAT cellular senescence, impaired adipogenesis and loss of subcutaneous WAT in old age. This preservation of WAT function has been suggested to be a potential mechanism...

... at giving a general view on the known mechanisms and summarizing the recent progress. Research currently focuses on adipose tissue inflammation as predominantly driven by adipose tissue macrophages, but also related alterations in other organs (liver, muscle, pancreas) have to be considered. Moreover, novel...

...Mark Walton A quantitative survey was carried out on the subcutaneous and abdominal adipose tissue of two inbred strains of mouse; STR/ORT is a strain in which the knee joints of the males have a very high incidence of osteoarthrosis, whereas the incidence of the disease in the females is much...

...M. Jeanjean; M. Dehez-Delhaye; A. Gommers A decrease of the basal glucose metabolism with senescence in the isolated rat adipose tissue has been demonstrated. In the presence of insulin, the oxidation of (U 14 C)- D -glucose and its incorporation into triglycerides are significantly increased...

... at adipocyte-related inflammation may represent an important means to prevent subclinical inflammation in the elderly, bearing a high risk of cardiovascular disease. 6 12 2005 13 03 2007 5 6 2007 Adipose tissue Atherosclerosis C-reactive protein Inflammation Waist circumference...