Leisure Activities, Genetic Risk, and Frailty: Evidence from the Chinese Adults Aged 80 Years or Older

3.

Clegg

A

,

Young

J

,

Iliffe

S

,

Rikkert

MO

,

Rockwood

K

.

Frailty in elderly people

.

Lancet

.

2013

;

381

(

9868

):

752

–

62

.

4.

Collard

RM

,

Boter

H

,

Schoevers

RA

,

Oude Voshaar

RC

.

Prevalence of frailty in community-dwelling older persons: a systematic review

.

J Am Geriatr Soc

.

2012

;

60

(

8

):

1487

–

92

.

5.

Cesari

M

,

Calvani

R

,

Marzetti

E

.

Frailty in older persons

.

Clin Geriatr Med

.

2017

;

33

(

3

):

293

–

303

.

6.

Hoogendijk

EO

,

Afilalo

J

,

Ensrud

KE

,

Kowal

P

,

Onder

G

,

Fried

LP

.

Frailty: implications for clinical practice and public health

.

Lancet

.

2019

;

394

(

10206

):

1365

–

75

.

7.

United Nations, Department of Economic and Social Affairs, Population Division

World population ageing 2019

New York

United Nations

2020

. [cited 2022 May 23]. Available from: https://www.un.org/en/development/desa/population/publications/pdf/ageing/WorldPopulationAgeing2019-Report.pdf.

8.

Lv

Y

,

Mao

C

,

Gao

X

,

Ji

JS

,

Kraus

VB

,

Yin

Z

.

The obesity paradox is mostly driven by decreased noncardiovascular disease mortality in the oldest old in China: a 20-year prospective cohort study

.

Nat Aging

.

2022

;

2

(

5

):

389

–

96

.

9.

Watanabe

D

,

Yoshida

T

,

Watanabe

Y

,

Yamada

Y

,

Kimura

M

Kyoto-Kameoka Study Group

.

A U-shaped relationship between the prevalence of frailty and body mass index in community-dwelling Japanese older adults: the Kyoto-Kameoka Study

.

J Clin Med

.

2020

9

5

E1367

.

10.

Yuan

L

,

Chang

M

,

Wang

J

.

Abdominal obesity, body mass index and the risk of frailty in community-dwelling older adults: a systematic review and meta-analysis

.

Age Ageing

.

2021

;

50

(

4

):

1118

–

28

.

11.

Ofori-Asenso

R

,

Chin

KL

,

Mazidi

M

,

Zomer

E

,

Ilomaki

J

,

Zullo

AR

.

Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis

.

JAMA Netw Open

.

2019

;

2

(

8

):

e198398

.

12.

Watts

P

,

Webb

E

,

Netuveli

G

.

The role of sports clubs in helping older people to stay active and prevent frailty: a longitudinal mediation analysis

.

Int J Behav Nutr Phys Act

.

2017

;

14

(

1

):

95

.

13.

Fushiki

Y

,

Ohnishi

H

,

Sakauchi

F

,

Oura

A

,

Mori

M

.

Relationship of hobby activities with mortality and frailty among community-dwelling elderly adults: results of a follow-up study in Japan

.

J Epidemiol

.

2012

;

22

(

4

):

340

–

7

.

14.

Morley

JE

,

Vellas

B

,

van Kan

GA

,

Anker

SD

,

Bauer

JM

,

Bernabei

R

.

Frailty consensus: a call to action

.

J Am Med Dir Assoc

.

2013

;

14

(

6

):

392

–

7

.

15.

Zeng

Y

,

Feng

Q

,

Hesketh

T

,

Christensen

K

,

Vaupel

JW

.

Survival, disabilities in activities of daily living, and physical and cognitive functioning among the oldest-old in China: a cohort study

.

Lancet

.

2017

;

389

(

10079

):

1619

–

29

.

16.

Li

Z

,

Chen

Q

,

Byers Kraus

V

,

Shen

D

,

Zhang

X

,

Zhang

P

.

Leisure activities and disability in activities of daily living among the oldest-old Chinese population: evidence from the Chinese Longitudinal Healthy Longevity Study

.

Aging

.

2020

;

12

(

11

):

10687

–

703

.

17.

Rogers

NT

,

Fancourt

D

.

Cultural engagement is a risk-reducing factor for frailty incidence and progression

.

J Gerontol B Psychol Sci Soc Sci

.

2020

;

75

(

3

):

571

–

6

.

18.

Kim

A

,

Yi

E

,

Kim

J

,

Kim

M

.

A study on the influence of social leisure activities on the progression to the stage of frailty in Korean seniors

.

Int J Environ Res Public Health

.

2020

;

17

(

23

):

8909

.

19.

Kasim

NF

,

Veldhuijzen van Zanten

J

,

Aldred

S

.

Tai Chi is an effective form of exercise to reduce markers of frailty in older age

.

Exp Gerontol

.

2020

;

135

:

110925

.

20.

Sathyan

S

,

Verghese

J

.

Genetics of frailty: a longevity perspective

.

Transl Res

.

2020

;

221

:

83

–

96

.

21.

Mekli

K

,

Marshall

A

,

Nazroo

J

,

Vanhoutte

B

,

Pendleton

N

.

Genetic variant of Interleukin-18 gene is associated with the frailty index in the English Longitudinal Study of Ageing

.

Age Ageing

.

2015

;

44

(

6

):

938

–

42

.

22.

Ho

Y-Y

,

Matteini

AM

,

Beamer

B

,

Fried

L

,

Xue

Q

,

Arking

DE

.

Exploring biologically relevant pathways in frailty

.

J Gerontol A Biol Sci Med Sci

.

2011

;

66

(

9

):

975

–

9

.

23.

Almeida

OP

,

Norman

PE

,

van Bockxmeer

FM

,

Hankey

GJ

,

Flicker

L

.

CRP 1846G>A polymorphism increases risk of frailty

.

Maturitas

.

2012

;

71

(

3

):

261

–

6

.

24.

Sathyan

S

,

Barzilai

N

,

Atzmon

G

,

Milman

S

,

Ayers

E

,

Verghese

J

.

Genetic insights into frailty: association of 9p21-23 locus with frailty

.

Front Med

.

2018

;

5

:

105

.

25.

Zeng

Y

.

Towards deeper research and better policy for healthy aging -using the unique data of Chinese longitudinal healthy longevity survey

.

China Econ J

.

2012

5

2–3

131

49

.

26.

Gu

D

,

Feng

Q

,

Zeng

Y

.

Chinese longitudinal healthy longevity study

. In:

Pachana

NA

, editor.

Encyclopedia of geropsychology

Singapore

Springer Singapore

2016

. p.

1

14

.

27.

Zhu

A

,

Wu

C

,

Yan

LL

,

Wu

C-D

,

Bai

C

,

Shi

X

.

Association between residential greenness and cognitive function: analysis of the Chinese Longitudinal Healthy Longevity Survey

.

BMJ Nutr Prev Health

.

2019

;

2

(

2

):

72

–

9

.

28.

Zhang

Y

,

Fu

S

,

Ding

D

,

Lutz

MW

,

Zeng

Y

,

Yao

Y

.

Leisure activities, APOE ε4, and cognitive decline: a longitudinal cohort study

.

Front Aging Neurosci

.

2021

;

13

:

736201

.

29.

Yin

Z

,

Brasher

M

,

Kraus

V

,

Lv

Y

,

Shi

X

,

Zeng

Y

.

Dietary diversity was positively associated with psychological resilience among elders: a population-based study

.

Nutrients

.

2019

;

11

(

3

):

650

.

30.

Gu

D

,

Dupre

ME

,

Sautter

J

,

Zhu

H

,

Liu

Y

,

Yi

Z

.

Frailty and mortality among Chinese at advanced ages

.

J Gerontol B Psychol Sci Soc Sci

.

2009

;

64

(

2

):

279

–

89

.

31.

Rockwood

K

,

Andrew

M

,

Mitnitski

A

.

A comparison of two approaches to measuring frailty in elderly people

.

J Gerontol A Biol Sci Med Sci

.

2007

;

62

(

7

):

738

–

43

.

32.

Jin

X

,

He

W

,

Zhang

Y

,

Gong

E

,

Niu

Z

,

Ji

J

.

Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: a cross-sectional study

.

PLoS Med

.

2021

;

18

(

6

):

e1003597

.

33.

Zeng

Y

,

Nie

C

,

Min

J

,

Chen

H

,

Liu

X

,

Ye

R

.

Sex differences in genetic associations with longevity

.

JAMA Netw Open

.

2018

;

1

(

4

):

e181670

.

34.

Marees

AT

,

de Kluiver

H

,

Stringer

S

,

Vorspan

F

,

Curis

E

,

Marie-Claire

C

.

A tutorial on conducting genome-wide association studies: quality control and statistical analysis

.

Int J Methods Psychiatr Res

.

2018

;

27

(

2

):

e1608

.

35.

Lv

Y

,

Kraus

VB

,

Gao

X

,

Yin

Z

,

Zhou

J

,

Mao

C

.

Higher dietary diversity scores and protein-rich food consumption were associated with lower risk of all-cause mortality in the oldest old

.

Clin Nutr

.

2020

;

39

(

7

):

2246

–

54

.

36.

Sterne

JAC

,

White

IR

,

Carlin

JB

,

Spratt

M

,

Royston

P

,

Kenward

MG

.

Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls

.

BMJ

.

2009

338

b2393

.

37.

Waljee

AK

,

Mukherjee

A

,

Singal

AG

,

Zhang

Y

,

Warren

J

,

Balis

U

.

Comparison of imputation methods for missing laboratory data in medicine

.

BMJ Open

.

2013

;

3

(

8

):

e002847

.

38.

Abeysekera

W

,

Sooriyarachchi

M

.

Use of Schoenfeld’s global test to test the proportional hazards assumption in the Cox proportional hazards model: an application to a clinical study

.

J Natn Sci Found Sri Lanka

.

2009

;

37

(

1

):

41

–

51

.

39.

Purcell

S

,

Neale

B

,

Todd-Brown

K

,

Thomas

L

,

Ferreira

MAR

,

Bender

D

.

PLINK: a tool set for whole-genome association and population-based linkage analyses

.

Am J Hum Genet

.

2007

;

81

(

3

):

559

–

75

.

40.

Wolf

SL

,

O’Grady

M

,

Easley

KA

,

Guo

Y

,

Kressig

RW

,

Kutner

M

.

The influence of intense Tai Chi training on physical performance and hemodynamic outcomes in transitionally frail, older adults

.

J Gerontol A Biol Sci Med Sci

.

2006

;

61

(

2

):

184

–

9

.

41.

García-Esquinas

E

,

Andrade

E

,

Martínez-Gómez

D

,

Caballero

FF

,

López-García

E

,

Rodríguez-Artalejo

F

.

Television viewing time as a risk factor for frailty and functional limitations in older adults: results from 2 European prospective cohorts

.

Int J Behav Nutr Phys Act

.

2017

;

14

(

1

):

54

.

42.

Mao

C

,

Li

Z

,

Lv

Y

,

Gao

X

,

Kraus

VB

,

Zhou

J

.

Specific leisure activities and cognitive functions among the oldest-old: the Chinese Longitudinal Healthy Longevity Survey

.

J Gerontol A Biol Sci Med Sci

.

2020

;

75

(

4

):

739

–

46

.

43.

Taniguchi

Y

,

Seino

S

,

Nishi

M

,

Tomine

Y

,

Tanaka

I

,

Yokoyama

Y

.

Association of dog and cat ownership with incident frailty among community-dwelling elderly Japanese

.

Sci Rep

.

2019

;

9

(

1

):

18604

.

44.

Kojima

G

,

Aoyama

R

,

Taniguchi

Y

.

Associations between pet ownership and frailty: a systematic review

.

Geriatrics

.

2020

;

5

(

4

):

89

.

45.

Zhao

M

,

Gao

J

,

Li

M

,

Wang

K

.

Relationship between loneliness and frailty among older adults in nursing homes: the mediating role of activity engagement

.

J Am Med Dir Assoc

.

2019

;

20

(

6

):

759

–

64

.

46.

Sun

J

,

Kong

X

,

Li

H

,

Chen

J

,

Yao

Q

,

Li

H

.

Does social participation decrease the risk of frailty? Impacts of diversity in frequency and types of social participation on frailty in middle-aged and older populations

.

BMC Geriatr

.

2022

;

22

(

1

):

553

.

47.

Hikichi

H

,

Aida

J

,

Matsuyama

Y

,

Tsuboya

T

,

Kondo

K

,

Kawachi

I

.

Community-level social capital and cognitive decline after a natural disaster: a natural experiment from the 2011 Great East Japan Earthquake and Tsunami

.

Soc Sci Med

.

2020

;

257

:

111981

.

48.

Li

Z

,

Zhang

X

,

Lv

Y

,

Shen

D

,

Li

F

,

Zhong

W

.

Leisure activities and all-cause mortality among the Chinese oldest-old population: a prospective community-based cohort study

.

J Am Med Dir Assoc

.

2020

;

21

(

6

):

713

9.e2

.

49.

Zhan

J

,

Sun

S

,

Chen

Y

,

Xu

C

,

Chen

Q

,

Li

M

.

MiR-3130-5p is an intermediate modulator of 2q33 and influences the invasiveness of lung adenocarcinoma by targeting NDUFS1

.

Cancer Med

.

2021

;

10

(

11

):

3700

–

14

.

50.

Dashti

S

,

Taherian-Esfahani

Z

,

Kholghi-Oskooei

V

,

Noroozi

R

,

Arsang-Jang

S

,

Ghafouri-Fard

S

.

In silico identification of MAPK14-related lncRNAs and assessment of their expression in breast cancer samples

.

Sci Rep

.

2020

;

10

(

1

):

8316

.

51.

Heinrichs

SKM

,

Hess

T

,

Becker

J

,

Hamann

L

,

Vashist

YK

,

Butterbach

K

.

Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

.

Cancer Med

.

2018

;

7

(

10

):

5057

–

65

.

52.

Dobashi

A

,

Togashi

Y

,

Tanaka

N

,

Yokoyama

M

,

Tsuyama

N

,

Baba

S

.

TP53 and OSBPL10 alterations in diffuse large B-cell lymphoma: prognostic markers identified via exome analysis of cases with extreme prognosis

.

Oncotarget

.

2018

;

9

(

28

):

19555

–

68

.

53.

Jiang

J

,

Bi

Y

,

Liu

X-P

,

Yu

D

,

Yan

X

,

Yao

J

.

To construct a ceRNA regulatory network as prognostic biomarkers for bladder cancer

.

J Cell Mol Med

.

2020

;

24

(

9

):

5375

–

86

.

54.

Zhao

Y

,

Scott

A

,

Zhang

P

,

Hao

Y

,

Feng

X

,

Somasundaram

S

.

Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis

.

Oncotarget

.

2017

;

8

(

30

):

48782

–

93

.

55.

Laczmanska

I

,

Sasiadek

MM

.

Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer

.

Acta Biochim Pol

.

2011

;

58

(

4

):

467

–

70

.

56.

Chen

C

,

Shi

C

,

Huang

X

,

Zheng

J

,

Zhu

Z

,

Li

Q

.

Molecular profiles and metastasis markers in Chinese patients with gastric carcinoma

.

Sci Rep

.

2019

;

9

(

1

):

13995

.

57.

Zhang

Z

,

Wang

J

,

Shen

B

,

Peng

C

,

Zheng

M

.

The ABCC4 gene is a promising target for pancreatic cancer therapy

.

Gene

.

2012

;

491

(

2

):

194

–

9

.

58.

Low

FG

,

Shabir

K

,

Brown

JE

,

Bill

RM

,

Rothnie

AJ

.

Roles of ABCC1 and ABCC4 in proliferation and migration of breast cancer cell lines

.

Int J Mol Sci

.

2020

21

20

E7664

.

59.

Bagnoli

M

,

Beretta

GL

,

Gatti

L

,

Pilotti

S

,

Alberti

P

,

Tarantino

E

.

Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma

.

BioMed Res Int

.

2013

;

2013

:

143202

.

60.

Lim

S-H

,

Shin

S

,

Kim

M-H

,

Kim

EC

,

Lee

DY

,

Moon

J

.

Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesis

.

J Cell Sci

.

2020

133

20

jcs243972

.

61.

Hyde

CL

,

Nagle

MW

,

Tian

C

,

Chen

X

,

Paciga

SA

,

Wendland

JR

.

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent

.

Nat Genet

.

2016

;

48

(

9

):

1031

–

6

.

62.

O’Brien

HE

,

Hannon

E

,

Hill

MJ

,

Toste

CC

,

Robertson

MJ

,

Morgan

JE

.

Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders

.

Genome Biol

.

2018

;

19

(

1

):

194

.

63.

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium

Ripke

S

,

Wray

NR

,

Lewis

CM

,

Hamilton

SP

,

Weissman

MM

.

A mega-analysis of genome-wide association studies for major depressive disorder

.

Mol Psychiatry

.

2013

;

18

(

4

):

497

–

511

.

64.

Andreassen

OA

,

Thompson

WK

,

Schork

AJ

,

Ripke

S

,

Mattingsdal

M

,

Kelsoe

JR

.

Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate

.

PLoS Genet

.

2013

;

9

(

4

):

e1003455

.

65.

Brandl

EJ

,

Lett

TA

,

Chowdhury

NI

,

Tiwari

AK

,

Bakanidze

G

,

Meltzer

HY

.

The role of the ITIH3 rs2535629 variant in antipsychotic response

.

Schizophr Res

.

2016

176

2–3

131

5

.

66.

Xie

X

,

Meng

H

,

Wu

H

,

Hou

F

,

Chen

Y

,

Zhou

Y

.

Integrative analyses indicate an association between ITIH3 polymorphisms with autism spectrum disorder

.

Sci Rep

.

2020

;

10

(

1

):

5223

.

67.

Burren

OS

,

Reales

G

,

Wong

L

,

Bowes

J

,

Lee

JC

,

Barton

A

.

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

.

Genome Med

.

2020

;

12

(

1

):

106

.

68.

Park

T-J

,

Kim

J-H

,

Pasaje

CF

,

Park

B-L

,

Bae

JS

,

Uh

S-T

.

Polymorphisms of ATF6B are potentially associated with FEV1 decline by aspirin provocation in asthmatics

.

Allergy Asthma Immunol Res

.

2014

;

6

(

2

):

142

–

8

.

69.

Palikhe

S

,

Uuganbayar

U

,

Trinh

HKT

,

Ban

G-Y

,

Yang

E-M

,

Park

H-S

.

A role of the ABCC4 gene polymorphism in airway inflammation of asthmatics

.

Mediators Inflamm

.

2017

;

2017

:

3549375

.

70.

Ramasamy

A

,

Kuokkanen

M

,

Vedantam

S

,

Gajdos

ZK

,

Couto Alves

A

,

Lyon

HN

.

Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA

.

PLoS ONE

.

2012

;

7

(

9

):

e44008

.

71.

James

G

,

Reisberg

S

,

Lepik

K

,

Galwey

N

,

Avillach

P

,

Kolberg

L

.

An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank

.

PLoS ONE

.

2019

;

14

(

4

):

e0215026

.

72.

Morris

DL

,

Fernando

MMA

,

Taylor

KE

,

Chung

SA

,

Alarcón-Riquelme

ME

,

Nititham

J

.

MHC associations with clinical and autoantibody manifestations in European SLE

.

Genes Immun

.

2014

;

15

(

4

):

210

–

7

.

73.

Barcellos

LF

,

May

SL

,

Ramsay

PP

,

Quach

HL

,

Lane

JA

,

Nititham

J

.

High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions

.

PLoS Genet

.

2009

;

5

(

10

):

e1000696

.

74.

Emmer

A

,

Brütting

C

,

Kornhuber

M

,

Staege

M

.

Genetic determinants of antibody levels in cerebrospinal fluid in multiple sclerosis: possible links to endogenous retroviruses

.

Int J Mol Sci

.

2018

;

19

(

3

):

786

.

75.

Goris

A

,

Pauwels

I

,

Gustavsen

MW

,

van Son

B

,

Hilven

K

,

Bos

SD

.

Genetic variants are major determinants of CSF antibody levels in multiple sclerosis

.

Brain

.

2015

138

Pt 3

632

43

.

76.

Mehta

D

,

Wani

S

,

Wallace

L

,

Henders

AK

,

Wray

NR

,

McCombe

PA

.

Cumulative influence of parity-related genomic changes in multiple sclerosis

.

J Neuroimmunol

.

2019

;

328

:

38

–

49

.

77.

Matesanz

F

,

González-Pérez

A

,

Lucas

M

,

Sanna

S

,

Gayán

J

,

Urcelay

E

.

Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1

.

PLoS One

.

2012

;

7

(

5

):

e36140

.

78.

de Lange

KM

,

Moutsianas

L

,

Lee

JC

,

Lamb

CA

,

Luo

Y

,

Kennedy

NA

.

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

.

Nat Genet

.

2017

;

49

(

2

):

256

–

61

.

79.

Peters

JE

,

Lyons

PA

,

Lee

JC

,

Richard

AC

,

Fortune

MD

,

Newcombe

PJ

.

Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immune-mediated disease

.

PLoS Genet

.

2016

;

12

(

3

):

e1005908

.

80.

Haritunians

T

,

Taylor

KD

,

Targan

SR

,

Dubinsky

M

,

Ippoliti

A

,

Kwon

S

.

Genetic predictors of medically refractory ulcerative colitis

.

Inflamm Bowel Dis

.

2010

;

16

(

11

):

1830

–

40

.

81.

Guo

S

,

Jin

Y

,

Zhou

J

,

Zhu

Q

,

Jiang

T

,

Bian

Y

.

MicroRNA variants and HLA-miRNA interactions are novel rheumatoid arthritis susceptibility factors

.

Front Genet

.

2021

;

12

:

747274

.

82.

Hider

SL

,

Thomson

W

,

Mack

LF

,

Armstrong

DJ

,

Shadforth

M

,

Bruce

IN

.

Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX

.

Rheumatology

.

2008

;

47

(

8

):

1156

–

9

.