Background: The World Health Organization has recently updated exercise guidelines for people aged >65 years, emphasizing the inclusion of multiple fitness components. However, without adequate recognition of individual differences, these guidelines may be applied using an approach that “one-size-fits-all.” Within the shifting paradigm toward an increasingly personalized approach to medicine and health, it is apparent that fitness components display a significant age-related increase in variability. Therefore, it is both logical and necessary to perform an accurate individualized assessment of multiple fitness components prior to optimal prescription for a personalized exercise program. Objective: The aim of the study was to test the feasibility and effectiveness of a novel tool able to remotely assess balance, flexibility, and strength using smartphone sensors (accelerometer/gyroscope), and subsequently deliver personalized exercise programs via the smartphone. Methods: We enrolled 52 healthy volunteers (34 females) aged 65+ years, with normal cognition and low fall risk. Baseline data from remote smartphone fitness assessment were analyzed to generate 42 fitness digital markers (DMs), used to guide personalized exercise programs (×5/week for 6 weeks) delivered via smartphone. Programs included graded exercises for upper/lower body, flexibility, strength, and balance (dynamic, static, and vestibular). Participants were retested after 6 weeks. Results: Average age was 74.7 ± 6.4 years; adherence was 3.6 ± 1.7 exercise sessions/week. Significant improvement for pre-/posttesting was observed for 10/12 DMs of strength/flexibility for upper/lower body (sit-to-stand repetitions/duration; arm-lift duration; torso rotation; and arm extension/flexion). Balance improved significantly for 6/10 measures of tandem stance, with consistent (nonsignificant) trends observed across 20 balance DMs of tandem walk and 1 leg stance. Balance tended to improve among the 37 participants exercising ≥3/week. Discussion: These preliminary results provide a proof of concept, with high adherence and improved fitness confirming the benefits of remote fitness assessment for guiding home personalized exercise programs among healthy adults aged >65 years. Further examination of the application within a randomized control study is necessary, comparing the personalized exercise program to general guidelines among healthy older adults, as well as specific populations, such as those with frailty, deconditioning, cognitive, or functional impairment. The study tool offers the opportunity to collect big data, including additional variables, with subsequent utilization of artificial intelligence to optimize the personalized exercise program.

1.
Daskalopoulou
C
,
Stubbs
B
,
Kralj
C
,
Koukounari
A
,
Prince
M
,
Prina
AM
.
Physical activity and healthy ageing: a systematic review and meta-analysis of longitudinal cohort studies
.
Ageing Res Rev
.
2017
;
38
:
6
17
. .
2.
American College of Sports Medicine (ACSM)
.
Exercise and physical activity for older adults
.
Med Sci Sports Exerc
.
2009
;
41
:
1510
30
.
3.
World Health Organization. WHO: Global recommendations on physical activity for health [Internet]. [cited 2021 May 6]. Available from: https://www.who.int/dietphysicalactivity/physical-activity-recommendations-65years.pdf.
4.
Tricco
AC
,
Thomas
SM
,
Veroniki
AA
,
Hamid
JS
,
Cogo
E
,
Strifler
L
,
Comparisons of interventions for preventing falls in older adults: a systematic review and meta-analysis
.
JAMA
.
2017
;
318
(
17
):
1687
99
. .
5.
Tieland
M
,
TrouwborstClark
IBC
,
Clark
BC
.
Skeletal muscle performance and ageing
.
J Cachexia Sarcopenia Muscle
.
2018
;
9
(
1
):
3
19
. .
6.
Stathokostas
L
,
Little
R
,
Vandervoort
AA
,
Paterson
DH
.
Flexibility training and functional ability in older adults: a systematic review
.
J Aging Res
.
2012
.
7.
Bull
FC
,
Al-Ansari
SS
,
Biddle
S
,
Borodulin
K
,
Buman
MP
,
Cardon
G
,
World Health Organization 2020 guidelines on physical activity and sedentary behaviour
.
Br J Sports Med
.
2020
;
54
(
24
):
1451
62
. .
8.
US Department of Health & Human Services, National Institute on Aging: NIA. Get fit for life: exercise & physical activity for healthy aging [Internet]. [cited 2021 May 6]. Available from: https://order.nia.nih.gov/sites/default/files/2018-04/nia-exercise-guide.pdf.
9.
European Union, Erasmus+ Programme, Project No: 2015-1 DEO2-KA204-002418. Wellbeing and healthy choices for older adults and their carers [Internet]. [cited 2021 May 6]. Available from: https://www.uni-muenster.de/ProjectWhole/category/physical-activity/.
10.
Khan
SS
,
Singer
BD
,
Vaughan
DE
.
Molecular and physiological manifestations and measurement of aging in humans
.
Aging cell
.
2017
;
16
(
4
):
624
33
. .
11.
Sagers
L
,
Melas-Kyriazi
L
,
Patel
CJ
,
Manrai
AK
.
Prediction of chronological and biological age from laboratory data
.
Aging
.
2020
;
12
(
9
):
7626
38
. .
12.
Belsky
DW
,
Caspi
A
,
Houts
R
,
Cohen
HJ
,
Corcoran
DL
,
Danese
A
,
Quantification of biological aging in young adults
.
Proc Natl Acad Sci U S A
.
2015
;
112
(
30
):
E4104
10
. .
13.
Bouchard
C
,
Antunes-Correa
LM
,
Ashley
EA
,
Franklin
N
,
Hwang
PM
,
Mattsson
CM
,
Personalized preventive medicine: genetics and the response to regular exercise in preventive interventions
.
Prog Cardiovasc Dis
.
2015 Jan–Feb
;
57
(
4
):
337
46
. .
14.
Di Liegro
I
.
Genetic and epigenetic modulation of cell functions by physical exercise
.
Genes
.
2019
;
10
(
12
):
1043
. .
15.
Müllers
P
,
Taubert
M
,
Müller
NG
.
Physical exercise as personalized medicine for dementia prevention?
Front Physiol
.
2019 29
;
10
:
672
. .
16.
Netz
Y
,
Lidor
R
,
Ziv
G
.
Small samples and increased variability: discussing the need for restricted types of randomization in exercise interventions in old age
.
Eur Rev Aging Phys Act
.
2019
;
16
(
1
):
17
. .
17.
Diehl
M
,
Hooker
K
,
Sliwinski
MJ
.
Handbook of intraindividual variability across the life span
.
UK
:
Routledge
;
2015
.
18.
Callisaya
ML
,
Blizzard
L
,
Schmidt
MD
,
McGinley
JL
,
Srikanth
VK
.
Ageing and gait variability: a population-based study of older people
.
Age Ageing
.
2010
;
39
(
2
):
191
7
. .
19.
Hultsch
DF
,
MacDonald
SWS
,
Dixon
RA
.
Variability in reaction time performance of younger and older adults
.
J Gerontol B Psychol Sci Soc Sci
.
2002
;
57
(
2
):
P101
15
. .
20.
Case
MA
,
Burwick
HA
,
Volpp
KG
,
Patel
MS
.
Accuracy of smartphone applications and wearable devices for tracking physical activity data
.
JAMA
.
2015
;
313
(
6
):
625
6
. .
21.
Armstrong
M
,
Vogiatzis
I
.
Personalized exercise training in chronic lung diseases
.
Respirology
.
2019
;
24
(
9
):
854
62
. .
22.
Hill
KD
,
Hunter
SW
,
Batchelor
FA
,
Cavalheri
V
.
Individualized home-based exercise programs for older people to reduce falls and improve physical performance: a systematic review and meta-analysis‏
.
Maturitas
.
2015
;
82
(
1
):
72
84
.
23.
Choudrie
J
,
Pheeraphuttranghkoon
S
,
Davari
S
.
The digital divide and older adult population adoption, use and diffusion of mobile phones: a quantitative study
.
Inf Syst Front
.
2020
;
22
(
3
):
673
95
. .
24.
Borson
S
,
Scanlan
JM
,
Chen
P
,
Ganguli
M
.
The Mini-Cog as a screen for dementia: validation in a population-based sample
.
J Am Geriatr Soc
.
2003
;
51
(
10
):
1451
4
. .
25.
Bhasin
S
,
Gill
TM
,
Reuben
DB
,
Latham
NK
,
Gurwitz
JH
,
Dykes
P
,
Strategies to reduce injuries and develop confidence in elders (STRIDE): a cluster-randomized pragmatic trial of a multifactorial fall injury prevention strategy: design and methods
.
J Gerontol A Biol Sci Med Sci
.
2018
;
73
(
8
):
1053
61
. .
26.
Rockwood
K
,
Rockwood
MR
,
Mitnitski
A
.
Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index
.
J Am Geriatr Soc
.
2010
;
58
(
2
):
318
23
. .
27.
Hoyl
MT
,
Alessi
CA
,
Harker
JO
,
Josephson
KR
,
Pietruszka
FM
,
Koelfgen
M
,
Development and testing of a five-item version of the Geriatric Depression Scale
.
J Am Geriatr Soc
.
1999
;
47
(
7
):
873
8
. .
28.
Tchelet
K
,
Stark-Inbar
A
,
Yekutieli
Z
.
Pilot Study of the EncephaLog smartphone application for gait analysis
.
Sensors
.
2019
;
19
(
23
):
5179
. .
29.
ProtoKinetics. Zeno walkway gait analysis system. Available from: https://www.protokinetics.com/zeno-walkway/ Accessed 2019 Nov 13.
30.
ProtoKinetics. Gait analysis software for medical device manufacturers. Available from: https://www.protokinetics.com/medical-device-manufacturers/ Accessed 2019 Nov 13.
31.
APDM Wearable Technologies. Comprehensive gait and balance analysis. Available from: https://www.apdm.com/mobility/ Accessed 2019 Nov 13.
32.
Furness
J
,
Schram
B
,
Cox
AJ
,
Anderson
SL
,
Keogh
J
.
Reliability and concurrent validity of the iPhone® Compass application to measure thoracic rotation range of motion (ROM) in healthy participants
.
PeerJ
.
2018
;
6
:
e4431
.
33.
Garber
CE
,
Blissmer
B
,
Deschenes
MR
,
Franklin
BA
,
Lamonte
MJ
,
Lee
IM
,
American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise
.
Med Sci Sports Exerc
.
2011
;
43
(
7
):
1334
. .
34.
Schrack
JA
,
Kuo
P-L
,
Wanigatunga
AA
,
Di
J
,
Simonsick
EM
,
Spira
AP
,
Active-to-sedentary behavior transitions, fatigability, and physical functioning in older adults
.
J Gerontol A Biol Sci Med Sci
.
2019
;
74
(
4
):
560
7
. .
35.
Schrack
JA
,
Wanigatunga
AA
,
Juraschek
SP
.
After the COVID-19 pandemic: the next wave of health challenges for older adults
.
J Gerontol A Biol Sci Med Sci
.
2020 Apr 21
.
36.
Borde
R
,
Hortobágyi
T
,
Granacher
U
.
Dose–response relationships of resistance training in healthy old adults: a systematic review and meta-analysis
.
Sports Med
.
2015
;
45
(
12
):
1693
720
.
37.
Taaffe
DR
,
Duret
C
,
Wheeler
S
,
Marcus
R
.
Once-weekly resistance exercise improves muscle strength and neuromuscular performance in older adults
.
J Am Geriatr Soc
.
1999
;
47
(
10
):
1208
14
. .
38.
Lesinski
M
,
Hortobágyi
T
,
Muehlbauer
T
,
Gollhofer
A
,
Granacher
U
.
Effects of balance training on balance performance in healthy older adults: a systematic review and meta-analysis
.
Sports Med
.
2015
;
45
(
12
):
1721
38
. .
39.
Yahalom
G
,
Yekutieli
Z
,
Israeli-Korn
SD
,
Elincx-Benizri
S
,
Livneh
V
,
Fay-Karmon
T
,
AppTUG-A smartphone application of instrumented “Timed Up and Go” for neurological disorders
.
EC Neurol
.
2018
;
10
:
689
95
.
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