Abstract
Scientists in the various fields of aging share a common goal - the extension of healthy life. However, claiming that the only way to accomplish this is to treat the complications of aging rather than its causes requires more than declarations made by proponents of SENS - it requires empirical research based on the scientific method. As this paper illustrates, it will be difficult to prove that SENS interventions work because the primary result of interest, negligible senescence, is not an outcome variable in empirical tests of SENS.
References
1.
Zealley B, de Grey ADNJ: Strategies for engineered negligible senescence. Gerontology 2013;59:183-189.
2.
de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJM, Stock G: Time to talk SENS: critiquing the immutability of human aging. Annals NY Acad Sci 2002;959:452-462.
3.
World Health Organization: The Global Burden of Disease. 2012. http://apps.who.int/ghodata/?vid=10012.
4.
World Economic Forum: Global Population Ageing: Peril or Promise - World Economic Forum, Global Agenda Council on an Ageing Society. Geneva, 2012.
5.
SENS: SENS Foundation: Advancing Rejuvenation Biotechnologies. 2012. http://www.sens.org/files/pdf/2011_Research_Report.pdf.
6.
Warner H, Anderson J, Austad S, et al: Science fact and the SENS agenda. EMBO Rep 2005;6:1106-1108.
7.
Butler RN, Miller RA, Perry D, Carnes BA, Williams TF, Cassel C, Brody J, Bernard MA, Partridge L, Kirkwood T, Martin GM, Olshansky SJ: New model of health promotion and disease prevention for the 21st century. Br Med J 2008;337:149-150.
8.
Miller RA: ‘Dividends' from research on aging - can biogerontologists, at long last, find something useful to do? J Gerontol A Biol Sci Med Sci 2009;64:157-160.
9.
Sierra F, Hadley E, Suzman R, Hodes R: Prospects for life span extension. Annu Rev Med 2008;60:457-469.
10.
Rae MJ, Butler RN, Campisi J, de Grey A, Finch CE, Gough M, Martin GM, Vijg J, Perrott KM, Logan BJ: The Demographic and Biomedical Case for Late-Life Interventions in Aging. Sci Transl Med 2010;2:40cm21.
© 2012 S. Karger AG, Basel
2012
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