Neurofílament accumulation was produced in neuronal perikarya of the lower brain stem nuclei in the hamster brain by inoculating buffy coat from a patient with Alzheimer’s disease. The abnormally proliferated neurofílament was characterized by immuno-staining and electron microscopy. The intracytoplasmic neurofílament accumulation was positively stained with anti-tau and anti-ubiquitin, but not with antibody against paired helical filaments. Experimental neurofibrillary changes were produced in the rabbit brain by aluminum injection, and the proliferated neurofilaments in the rabbit brain were compared with those in the hamster brain inoculated with Alzheimer buffy coat. The results indicate that the long pathological process in the hamster brain is triggered by Alzheimers buffy coat inoculation which results in intracytoplasmic accumulation of modified neurofilaments.

Keywords:
Alzheimer’s disease, Neurofílament, Aluminum, Buffy coat, Ubiquitin, Tau
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© 1991 S. Karger AG, Basel
1991
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