We have previously reported a correlation between the number (Bmax) of striatal D2-dopamine receptors in youth and the magnitude of the decrease to the 40th to 60th week of age. This correlation was observed in five inbred strains of mice, which differ over a 2-fold range in youthful Bmax. To determine the extent to which this correlation can predict changes in strains, other than those so far examined, we measured the binding of [3H]spiperone to striatal membranes in two additional strains (MRL/Mp-++ and DBA/2NNia), in one strain previously tested, C57BL/6, but now maintained in pathogen-free conditions (C57BL/6NNia), and in hybrids (C6D2F1) of C57BL/6NNia and DBA/2NNia mice. The results were as expected from the correlation observed with other strains; that is, the magnitude of decline in Bmax with age is correlated with the density of receptors in youth. To test the stability of these age-related changes, we examined the effect of feeding diets with high (4.5) and low (0.2) polyunsaturated to saturated fatty acid (P/S) ratios to SJL/J and MRL/Mp-++ mice and found both receptor density and affinity and their age-related change to be independent of the dietary P/S ratio. In conclusion, our data are consistent with ‘economic correction’, i.e. with a direct correlation between youthful quantity of striatal D2-dopamine receptors and subsequent extent of decrease with aging.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.