Creatine phosphokinase (CPK) has been shown to provide the initial ATP for muscle contraction. The effect of wheel running on CPK levels was compared in hindleg and cardiac muscles of young, intermediate-age and old outbred CW-1 and inbred C57BL mice. Short-term (5 weeks) and long-term (over 12 months) regimens were used in these studies. It was shown that as a function of age there was a 20–30% decrease of CPK activity in hindleg muscles of old sedentary animals. No change with age was observed in cardiac muscles of old animals. Short-term exercise of 5 weeks resulted in an increase in CPK levels in young running mice in both hindleg and cardiac muscles. In old animals there was a slight decrease in striated hindleg muscles, but no change in cardiac muscles. In the long-term exercise group, young (6-month-old) and intermediate-age (15-month-old) animals showed a 20–40 % increase in CPK specific activity in hindleg muscles over sedentary control mice. No such increase in CPK activity was observed in old trained mice. However, the long-term exercise regimen prevented the age-associated decline in CPK activity found in sedentary animals.

Keywords:
Creatine phosphokinase, Exercise, Muscle
This content is only available via PDF.
© 1987 S. Karger AG, Basel
1987
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.