Immunologic recovery from radiation injury was used to assess age-related loss of immunologic homeostasis. Mice were exposed to 500 rad to determine whether macrophages, T helper cells and/or T responder cells were responsible for the age-related delay in recovery of PHA-induced mitogenesis. Recovery of macrophages was determined by facilitation of macrophage-deficient cultures, recovery of T helper cells by interleukin 2 production, and recovery of T responder cells by incorporation of tritiated thymidine. The results showed that in old mice (a) macrophages are resistant to radiation and aging, (b) T helper cells recover completely from radiation, and (c) recovery is incomplete for T responder cells.

Keywords:
Loss of homeostasis, T cells, Macrophages, Radiation injury, Immunologic recovery, Mitogenesis, Phytohemagglutinin
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© 1986 S. Karger AG, Basel
1986
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