Polyacrylamide gel electrophoresis of the H1 group of histones extracted from different rat and mouse tissues shows a different pattern of fractions (HI, H1°, H1° met) when the two species are compared. Different tissues of each species also have a different pattern of HI histone fraction and subfraction. However, the age-associated changes of mouse HI histones from liver and spleen chromatin show the same type of alteration of fraction ratios which had been demonstrated in our earlier research with rat tissues. In both species there is a relative increase of the F1° and F1° met fractions in tissues from old animals. The presence of the F1° fraction in only non-dividing cells suggests that there may be an age-specific type of chromatin condensation.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.