... associ­ ated with gene insertion using retroviruses Random integration Insertional mutagenesis Activation of oncogenes adjacent to insertion site Recombination of viral genome to form replicating infectious particles tion of the retrovirus is random, leading to potential problems of stability and expres­...

... insertion using retroviruses Random integration Inscrtional mutagenesis Activation of oncogenes adjacent to insertion site Recombination of viral genome to form replicating infectious particles RNA viruses of the retrovirus type are currently the center of most interest as bio­ logic vectors for gene...