Abstract
Introduction: Inflammatory bowel diseases, which are among the most common chronic gastrointestinal diseases, can also affect the voice for different reasons. The aim of this study was to investigate acoustic, perceptual, and subjective voice evaluation parameters in inflammatory bowel diseases (IBD). Methods: This prospective case-control study included a total of 80 participants: 28 patients with ulcerative colitis (UC), 22 patients with Crohn’s disease (CD), and 30 healthy controls. Following the endoscopic examination, the fundamental frequency (F0), shimmer (dB), jitter (%), and harmonic/noise ratio (HNR) were measured. GRBAS (grade, roughness, breathiness, asthenia, strain) scale was used for perceptual evaluation, and Voice Handicap Index-10 (VHI-10) Turkish version was used for subjective assessment. Results: The F0 value was within normal limits in both disease groups in male and female participants and in the control group. Jitter and shimmer values were statistically higher in the UC and CD groups than in the control group. HNR did not differ between CD and control; however, it was statistically lower in the UC group when compared to both the control and CD groups. The total GRBAS score did not differ between the UC and CD groups; however, it was greater in IBD patients compared to the control group. However, these differences were within normative parameters. Although total VHI-10 score did not differ between UC and CD groups, both had a higher voice handicap than the control group. Conclusion: IBD might have an effect on the voice and voice quality. This disease group was discovered to have perceptual and subjective voice problems additionally.
Journal Section:
Research Article
References
1.
Zhang
YZ
, Li
YY
. Inflammatory bowel disease: pathogenesis
. World J Gastroenterol
. 2014
;20
(1
):91
–9
.2.
Loos
E
, Lemkens
P
, Poorten
VV
, Humblet
E
, Laureyns
G
. Laryngeal manifestations of inflammatory bowel disease
. J Voice
. 2019
;33
(1
):1
–6
.3.
Sarı
H
, Saltürk
Z
, Kumral
TL
, Gökden
Y
, Enise Goker
A
, Baskadem Yilmazer
A
. Evaluation of the laryngeal involvement and voice quality in Crohn disease
. B-ENT
. 2021
;16
(4
):217
–21
.4.
Bernstein
CN
, Benchimol
EI
, Bitton
A
, Murthy
SK
, Nguyen
GC
, Lee
K
et al. The impact of inflammatory bowel disease in Canada 2018: extra-intestinal diseases in IBD
. J Can Assoc Gastroenterol
. 2019
2
Suppl 1
S73
80
.5.
Harpaz
N
, Polydorides
AD
. Upper gastrointestinal manifestations of inflammatory bowel disease
. Surg Pathol Clin
. 2020
;13
(3
):413
–30
.6.
Rogler
G
, Singh
A
, Kavanaugh
A
, Rubin
DT
. Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management
. Gastroenterology
. 2021
;161
(4
):1118
–32
.7.
Dejonckere
PH
, Bradley
P
, Clemente
P
, Cornut
G
, Crevier-Buchman
L
, Friedrich
G
et al. A basic protocol for functional assessment of voice pathology, especially for investigating the efficacy of (phonosurgical) treatments and evaluating new assessment techniques. Guideline elaborated by the Committee on Phoniatrics of the European Laryngological Society (ELS)
. Eur Arch Oto-Rhino-Laryngol
. 2001
;258
(2
):77
–82
.8.
Skuk
VG
, Schweinberger
SR
. Influences of fundamental frequency, formant frequencies, aperiodicity, and spectrum level on the perception of voice gender
. J Speech Lang Hear Res
. 2014
;57
(1
):285
–96
.9.
Teixeira
JP
, Oliveira
C
, Lopes
C
. Vocal acoustic analysis–jitter, shimmer and hnr parameters
. Procedia Technology
. 2013
;9
:1112
–22
.10.
Boersma
P
. Accurate short-term analysis of the fundamental frequency and the harmonic-to-noise ratio of a sample sound
. IFA Proc
. 1993
;17
:97
–110
.11.
Karnell
MP
, Melton
SD
, Childes
JM
, Coleman
TC
, Dailey
SA
, Hoffman
HT
. Reliability of clinician-based (GRBAS and CAPE-V) and patient-based (V-RQOL and IPVI) documentation of voice disorders
. J Voice
. 2007
;21
(5
):576
–90
.12.
Kilic
MA
, Okur
E
, Yildirim
I
, Ogut
F
, Denizoglu
I
, Kizilay
A
et al. [Reliability and validity of the Turkish version of the voice handicap index]
. Kulak Burun Bogaz Ihtis Derg
. 2008 May-Jun
18
3
139
47
.13.
Rosen
CA
, Lee
AS
, Osborne
J
, Zullo
T
, Murry
T
. Development and validation of the voice handicap index-10
. Laryngoscope
. 2004
;114
(9
):1549
–56
.14.
Jose
FA
, Heyman
MB
. Extraintestinal manifestations of inflammatory bowel disease
. J Pediatr Gastroenterol Nutr
. 2008
;46
(2
):124
–33
.15.
Gurbuzler
L
, Inanir
A
, Yelken
K
, Koc
S
, Eyibilen
A
, Uysal
IO
et al. Behcet’s disease impairs voice quality without laryngeal and hypopharyngeal involvement
. Eur Arch Oto-Rhino-Laryngol
. 2012
;269
(12
):2539
–42
.16.
Hiller
AS
, Tschernig
T
, Kleemann
WJ
, Pabst
R
. Bronchus-associated lymphoid tissue (BALT) and Larynx-Associated Lymphoid Tissue (LALT) are found at different frequencies in children, adolescents and adults
. Scand J Immunol
. 1998
;47
(2
):159
–62
.17.
Rees
LE
, Ayoub
O
, Haverson
K
, Birchall
MA
, Bailey
M
. Differential major histocompatibility complex class II locus expression on human laryngeal epithelium
. Clin Exp Immunol
. 2003
;134
(3
):497
–502
.18.
Jecker
P
, Ptok
M
, Pabst
R
, Westermann
J
. Distribution of immunocompetent cells in various areas in the normal laryngeal mucosa of the rat
. Eur Arch Oto-Rhino-Laryngol
. 1996
;253
(3
):142
–6
.19.
Gorti
GK
, Birchall
MA
, Haverson
K
, Macchiarini
P
, Bailey
M
. A preclinical model for laryngeal transplantation: anatomy and mucosal immunology of the porcine larynx
. Transplantation
. 1999
;68
(11
):1638
–42
.20.
Hasegawa
N
, Ishimoto
S
, Takazoe
M
, Tsunoda
K
, Fujimaki
Y
, Shiraishi
A
et al. Recurrent hoarseness due to inflammatory vocal fold lesions in a patient with Crohn's disease
. Ann Otol Rhinol Laryngol
. 2009
;118
(7
):532
–5
.21.
Liu
ZW
, Masterson
LM
, Srouji
IA
, Musonda
P
, Scott
DG
. Voice symptoms in patients with autoimmune disease: a cross-sectional epidemiological study
. Otolaryngol Head Neck Surg
. 2012
;147
(6
):1108
–13
.22.
Hamdan
AL
, Sarieddine
D
. Laryngeal manifestations of rheumatoid arthritis
. Autoimmune Dis
. 2013
;2013
:103081
.23.
Roy
N
, Tanner
K
, Merrill
RM
, Wright
C
, Miller
KL
, Kendall
KA
. Descriptive epidemiology of voice disorders in rheumatoid arthritis: prevalence, risk factors, and quality of life burden
. J Voice
. 2016
;30
(1
):74
–87
.24.
Weinreb
SF
, Piersiala
K
, Hillel
AT
, Akst
LM
, Best
SR
. Dysphonia and dysphagia as early manifestations of autoimmune inflammatory myopathy
. Am J Otolaryngol
. 2021
;42
(1
):102747
.25.
Ferro
JM
, Oliveira
SN
, Correia
L
. Neurologic manifestations of inflammatory bowel diseases
. Handb Clin Neurol
. 2014
;120
:595
–605
.26.
Raphael
LJ
, Borden
GJ
, Harris
KS
Speech science primer: physiology, acoustics, and perception of speech
. Lippincott Williams & Wilkins
. 2007
.27.
Kiliç
MA
, Oğüt
F
, Dursun
G
, Okur
E
, Yildirim
I
, Midilli
R
. The effects of vowels on voice perturbation measures
. J Voice
. 2004
;18
(3
):318
–24
.28.
Barberio
B
, Zamani
M
, Black
CJ
, Savarino
EV
, Ford
AC
. Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis
. Lancet Gastroenterol Hepatol
. 2021
;6
(5
):359
–70
.29.
Lechien
JR
, Geneid
A
, Bohlender
JE
, Cantarella
G
, Avellaneda
JC
, Desuter
G
et al. Consensus for voice quality assessment in clinical practice: guidelines of the European Laryngological Society and Union of the European Phoniatricians
. Eur Arch Oto-Rhino-Laryngol
. 2023
;280
(12
):5459
–73
.S. Karger AG, Basel
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
2024
You do not currently have access to this content.
