Objective: This prospective follow-up study aimed to identify sociodemographic and clinical factors that may affect the quality of life (QoL) of patients with acute ischemic stroke during a 6-month follow-up. Patients and Methods: In the acute phase, sociodemographic and clinical data were collected using the National Institute of Health Stroke Scale, Barthel Index, and modified Rankin Scale. QoL was assessed with the Stroke and Aphasia Quality of Life Scale-39 6 months after stroke. Results: QoL was evaluated in 64 patients (aged 45-81 years) with a first-ever ischemic stroke. Thrombolytic therapy was given to 80% of the patients. Stroke severity, dependence in activities of daily living, degree of handicap, and length of hospitalization were associated with QoL. QoL was not associated with age, gender, marital status, or years of education. Conclusion: In this study, most patients were treated with thrombolysis, and QoL results resembled those of earlier studies on patients without thrombolysis. Despite good physical recovery, the patients reported impairments in QoL. QoL assessments can give clinicians a more holistic picture of stroke recovery from the patient's perspective.

Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V: Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol 2009;8:355-369.
Stroke. Current Care Guidelines. Working Group set up by the Finnish Medical Society Duodecim and the Finnish Neurological Society. Helsinki: the Finnish Medical Society Duodecim, 2011. www.kaypahoito.fi/web/kh/suositukset/.
Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al: Heart disease and stroke statistics 2011 update: a report from the American Heart Association. Circulation 2011;123:e18-e209.
Hankey GJ, Jamrozik KD, Broadhurst RJ, Forbes S, Anderson CS: Long-term disability after first-ever stroke and related prognostic factors in the Perth Community Stroke Study, 1989-1990. Stroke 2002;33:1034-1040.
Hacke W, Kaste M, Bluhmki E, Brozman M, Dávalos A, Guidetti D, et al: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 2008;359:1317-1329.
Bushnell CD, Reeves MJ, Zhao X, Pan W, Prvu-Bettger J, Zimmer L, Olson D, Peterson E: Sex differences in quality of life after ischemic stroke. Neurology 2014;82:922-931.
Franzen-Dahlin A, Laska AC: Gender differences in quality of life after stroke and TIA: a cross-sectional survey of out-patients. J Clin Nurs 2012;21:2386-2391.
Hallan S, Asberg A, Indredavik B, Wideroe TE: Quality of life after cerebrovascular stroke: a systematic study of patients' preferences for different functional outcomes. J Intern Med 1999;246:309-316.
Rachpukdee S, Howteerakul N, Suwannapong N, Tang-Aroonsin S: Quality of life of stroke survivors: a 3-month follow-up study. J Stroke Cerebrovasc Dis 2013;22:e70-e78.
Nys GM, van Zandvoort MJ, van der Worp HB, de Haan EH, de Kort PL, Jansen BP, Kappelle LJ: Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke. J Neurol Sci 2006;247:149-156.
Singhpoo K, Charerntanyarak L, Ngamroop R, Hadee N, Chantachume W, Lekbunyasin O, Sawanyawisuth K, Tiamkao S: Factors related to quality of life of stroke survivors. J Stroke Cerebrovasc Dis 2012;21:776-781.
Tang WK, Lau CG, Mok V, Ungvari GS, Wong KS: Apathy and health-related quality of life in stroke. Arch Phys Med Rehabil 2014;95:857-861.
King RB: Quality of life after stroke. Stroke 1996;27:1467-1472.
Manders E, Dammekens E, Leemans I, Michiels K: Evaluation of quality of life in people with aphasia using a Dutch version of the SAQOL-39. Disabil Rehabil 2010;32:173-182.
de Haan RJ, Limburg M, Van der Meulen JH, Jacobs HM, Aaronson NK: Quality of life after stroke. Impact of stroke type and lesion location. Stroke 1995;26:402-408.
Schiemanck SK, Post MW, Kwakkel G, Witkamp TD, Kappelle LJ, Prevo AJ: Ischemic lesion volume correlates with long-term functional outcome and quality of life of middle cerebral artery stroke survivors. Restor Neurol Neurosci 2005;23:257-263.
Luengo-Fernandez R, Gray AM, Bull L, Welch S, Cuthbertson F, Rothwell PM, Oxford Vascular S: Quality of life after TIA and stroke: ten-year results of the Oxford Vascular Study. Neurology 2013;81:1588-1595.
Williams LS, Weinberger MH, Harris LE, Biller J: Measuring quality of life in a way that is meaningful to stroke patients. Neurology 1999;53:1839-1843.
Cortez MM, Wilder MJ, McFadden M, Majersik JJ: Quality of life after intra-arterial therapy for acute ischemic stroke. J Stroke Cerebrovasc Dis 2014;23:1890-1896.
Robinson-Smith G, Johnston MV, Allen J: Self-care self-efficacy, quality of life, and depression after stroke. Arch Phys Med Rehabil 2000;81:460-464.
Abubakar SA, Isezuo SA: Health related quality of life of stroke survivors: experience of a stroke unit. Int J Biomed Sci 2012;8:183-187.
Carod-Artal J, Egido JA, Gonzalez JL, Varela de Seijas E: Quality of life among stroke survivors evaluated 1 year after stroke: experience of a stroke unit. Stroke 2000;31:2995-3000.
Kauhanen ML, Korpelainen JT, Hiltunen P, Maatta R, Mononen H, Brusin E, Sotaniemi KA, Myllyla VV: Aphasia, depression, and non-verbal cognitive impairment in ischaemic stroke. Cerebrovasc Dis 2000;10:455-461.
Shyu YI, Maa SH, Chen ST, Chen MC: Quality of life among older stroke patients in Taiwan during the first year after discharge. J Clin Nurs 2009;18:2320-2328.
Galanth S, Tressieres B, Lannuzel A, Foucan P, Alecu C: Factors influencing prognosis and functional outcome one year after a first-time stroke in a Caribbean population. Arch Phys Med Rehabil 2014;95:2134-2139.
Goldstein LB, Bertels C, Davis JN: Interrater reliability of the NIH stroke scale. Arch Neurol 1989;46:660-662.
Adams HPJ, Davis PH, Leira EC, Chang KC, Bendixen BH, Clarke WR, Woolson RF, Hansen MD: Baseline NIH Stroke Scale score strongly predicts outcome after stroke: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology 1999;53:126-131.
IST-3 Collaborative Group: Effect of thrombolysis with alteplase within 6 h of acute ischaemic stroke on long-term outcomes (the third International Stroke Trial [IST-3]): 18-month follow-up of a randomised controlled trial. Lancet neurol 2013;12:768-776.
de Weerd L, Luijckx GJ, Groenier KH, van der Meer K: Quality of life of elderly ischaemic stroke patients one year after thrombolytic therapy. A comparison between patients with and without thrombolytic therapy. BMC Neurol 2012;12:61.
Mahoney F, Barthel D: Functional evaluation: the Barthel Index. Md State Med J 1965;14:61-65.
Rankin J: Cerebral vascular accidents in patients over the age of 60. II. Prognosis. Scott Med J 1957;2:200-215.
Hilari K, Byng, S, Lamping DL, Smith SC: Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39): evaluation of acceptability, reliability, and validity. Stroke 2003;34:1944-1950.
Constantinidou F, Prokopiou J, Nikou M, Papacostas S: Cognitive-linguistic performance and quality of life in healthy aging. Folia Phoniatr Logop 2015;67:145-155.
Wang YL, Pan YS, Zhao XQ, Wang D, Johnston SC, Liu LP, et al: Recurrent stroke was associated with poor quality of life in patients with transient ischemic attack or minor stroke: finding from the CHANCE trial. CNS Neurosci Ther 2014;20:1029-1035.
Haghgoo HA, Pazuki ES, Hosseini AS, Rassafiani M: Depression, activities of daily living and quality of life in patients with stroke. J Neurol Sci 2013;328:87-91.
Hilari K, Klippi A, Constantinidou F, Horton S, Penn C, Raymer A, et al: An international perspective on quality of life in aphasia: a survey of clinician views and practices from sixteen countries. Folia Phoniatr Logop 2015;67:119-130.
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