.... Discussion and Conclusion: We conclude that, under these experimental conditions, the leaf extracts effectively suppress CCl 4 -induced oxidative stress. Our findings provide evidence to demonstrate that the possible mechanism of this activity may be due to the strong antioxidant property of the leaves...

.... Oxidative stress develops when antioxidants are overwhelmed by ROS. This may occur via overproduction of the latter and/or by deficiency of antioxidant defense. ROS in excess, especially the highly reactive hydroxyl radical (HO·), which is usually generated with the catalytic help of transition metals...

... tuned, sophisticated equilibrium can result in oxidative stress unleashing a cascade of pathological processes. This review summarizes the general aspects of the analytical methods used for the detection of an excess of free radicals together with a critical evaluation of the results obtained...