Naturopathic reflex therapies such as massage, Gua Sha massage, cupping, wet packs etc. are likely able to influence chronic pain at different levels of the nociceptive system. Since naturopathic reflex therapies have been shown to reduce symptoms of chronic pain and often utilize intense manipulation of the environment of the nociceptor (e.g. Gua Sha massage or cupping), it can be hypothesized that they unfold part of their effect at the level of the peripheral nociceptor and the spinal cord. However, these hypotheses have to date not been tested systematically. Standardized sensory testing, e.g., as performed by ‘quantitative sensory testing' (QST), a comprehensive battery of tests for clinical trials, may offer additional information about the mechanisms of naturopathic reflex therapies since it provides a measure for the mechanisms of nociceptive pain on all levels of the pain processing system. This method paper describes the potential role of QST in research on the neurobiological mechanisms of naturopathic reflex therapies.

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