...Belinda Shao; Christian Schroeder; Emilija Sagaityte; Olivia A. Kozel; Morgan Pedus; Debra Watson-Smith; Julie Monteagudo; Francois I. Luks; Stephen R. Carr; Petra M. Klinge; Konstantina A. Svokos Introduction: Spina bifida guidelines recommend neurosurgical involvement in prenatal counseling...

...Julia Wawrla-Zepf; Ladina Vonzun; Ladina Rüegg; Nele Strübing; Franziska Krähenmann; Martin Meuli; Luca Mazzone; Ueli Moehrlen; Spina Bifida Study Group Zurich; Nicole Ochsenbein-Kölble Introduction: Chorioamniotic membrane separation (CMS) is a known complication after fetal spina bifida (fSB...

... strength Stress Strain Stretch Membrane separation Membrane closure Spina bifida There has been rapid improvement and development of fetal invasive procedures for both diagnosis and therapeutic purposes, such as fetoscopic laser surgery for twin-twin transfusion syndrome (TTTS) and fetoscopic...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2024 MOMS Spina bifida Myelomeningocele MOMS criteria Patient...

...Julia Zepf; Anita Züger; Ladina Vonzun; Ladina Rüegg; Nele Strübing; Franziska Krähenmann; Martin Meuli; Luca Mazzone; Ueli Moehrlen; Spina Bifida Study Group Zurich; Nicole Ochsenbein-Kölble Introduction: For open fetal spina bifida (fSB) repair, a maternal laparotomy is required. Hence, enhanced...

...Su Yeon Lee; Yimeng Du; Abd-Elrahman Said Hassan; Erin Brown; Payam Saadai; Shinjiro Hirose; Aijun Wang; Diana L. Farmer Spina bifida is the most common congenital anomaly of the central nervous system and the first non-fatal fetal lesions to be addressed by fetal intervention. While research...

...Julia Zepf; Ladina Vonzun; Franziska Krähenmann; Nele Strübing; Ueli Moehrlen; Martin Meuli; Luca Mazzone; Theres Moehrlen; Nicole Ochsenbein-Kölble Introduction: Fetal spina bifida (SB) repair is a distinct therapeutic option in selected cases. Since this procedure may not only be associated...

...). In this large multicenter study of open maternal-fetal surgery (OMFS) for spina bifida, an anterior placental location was associated with an increased risk of rare intraoperative fetal complications, including fetal bradycardia, as well as the increased thinning and separation of the maternal hysterotomy site...

...David-Alexander Wille; Beth Padden; Ueli Moehrlen; Beatrice Latal; Sonja Schauer; Raimund Kottke; Patrice Grehten; Martin Meuli Introduction: This retrospective study investigates brain malformations and their impact on neurodevelopmental outcome in children after prenatal surgery for spina bifida...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Animal model Fetal surgery Myelomeningocele Spina bifida Myelomeningocele (MMC), the most severe form of spina bifida, is a birth defect resulting from incomplete closure...

...-González; Israel Juárez-Martínez; Rosa Villalobos-Gómez; Carlos Rebolledo-Fernández Objectives: The aim of the study was to describe the feasibility of open fetal microneurosurgery for intrauterine spina bifida (SB) repair and to compare perinatal outcomes with cases managed using the classic open fetal...

...Michal Fishel Bartal; Eric P. Bergh; Kuojen Tsao; Mary T. Austin; Kenneth J. Moise; Stephen A. Fletcher; Baha M. Sibai; Ramesha Papanna Objective: The 2 types of maternal skin incisions for in utero spina bifida repair are low transverse (LT) incision perceived to be cosmetic benefit and midline...

...Waldo Sepulveda; Edgardo Corral; Juan L. Alcalde; Felipe Otayza; Jose M. Müller; Franco Ravera; Juan C. Devoto; Mirta Tapia Objective: To report the experience with prenatal repair of open spina bifida (OSB) from 2 centers in Chile. Methods: Women with a second-trimester fetus with OSB were offered...

...Luca Mazzone; Alice Catherine Hölscher; Ueli Moehrlen; Rita Gobet; Martin Meuli; Maya Horst Introduction: Neurogenic lower urinary tract dysfunction (NLUTD) represents a severe burden for patients with open spina bifida (OSB). The effect of fetal OSB repair on the urological outcome remains unclear...

...Stefanie P. Lazow; Sarah A. Tracy; Alexander V. Chalphin; Ina Kycia; David Zurakowski; Dario O. Fauza Purpose: Transamniotic stem cell therapy (TRASCET) with mesenchymal stem cells (MSCs) can induce spina bifida coverage with neoskin. We initiated a mechanistic analysis of this host response...

... of earlier MMC defect repair and fetal loss remains unclear, though this may be due to cumulative stress of fetal surgical intervention and membrane disruption. National Institutes of Health (NIH) 10.13039/100000002 Fetal surgery Myelomeningocele Spina bifida Animal disease models...

... Congenital malformations Fetal surgery Intrauterine surgery Myelomeningocele Spina bifida Open in utero treatment of myelomeningocele (MMC) has become an optional treatment in large fetal surgery centers worldwide. The Management of Myelomeningocele study (MOMS) has shown the benefits of open...

...Ueli Moehrlen; Julia Elrod; Nicole Ochsenbein-Kölble; Christoph Berger; Roberto F. Speck; Luca Mazzone; Franziska Krähenmann; Roland Zimmermann; Martin Meuli Background: Fetal surgery for spina bifida aperta may lead to significantly better outcomes than postnatal repair, particularly regarding...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Spina bifida Fetal surgery Prenatal diagnosis Preoperative evaluation Magnetic resonance imaging We conducted...

... of Myelomeningocele Study, a.k.a. the MOMS trial, was published in 2011 in the New England Journal of Medicine . This prospective randomized controlled trial proved to be a milestone publication that provided definitive evidence that fetal surgery is a novel standard of care for select fetuses with spina bifida...