... profile of angiogenic factors in the third trimester and to assess their ability to predict term preeclampsia (PE). Methods: A cohort of low-risk pregnant women was scheduled for a uterine Doppler evaluation and measurement of the circulating levels of angiogenic factors at ∼30 and ∼36 weeks...

... with intact membrane Pregnancy Preeclampsia Preterm birth Rapid point-of-care test Receptor sFlt-1 VEGF Preterm labor with intact membranes (PTL), a phenotype of spontaneous preterm delivery, is characterized by the onset of regular uterine activity accompanied by cervical changes, leading...

... (PlGF) ratio alone or in a multi-marker regression model for preeclampsia-related maternal and/or fetal adverse outcomes in women >34 weeks of gestation. Methods: We analyzed the data collected from 655 women with suspected preeclampsia. Adverse outcomes were predicted by multivariable...

... diseases related to placental dysfunction, such as preeclampsia or fetal growth restriction (FGR). Methods: This was a prospective study among all twin pregnancies followed up at a tertiary hospital. The sFlt-1/PlGF ratio was determined at 24 weeks. Results: A total of 108 patients with a twin gestation...

... coronavirus 2 COVID-19 First trimester Preeclampsia Obstetric outcomes The impact of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak on pregnancy is still a major concern for the obstetric community. The immune and respiratory physiologic adaptations to pregnancy pose...

...Charlotte Kvist Ekelund; Line Rode; Ann Tabor; Jon Hyett; Andrew McLennan Objective: The study aimed to investigate the association between placental growth factor (PlGF) and adverse obstetric outcomes in a mixed-risk cohort of pregnant women screened for preeclampsia (PE) in the first trimester...

... Objective: Establish reference ranges for the Elecsys® soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) immunoassay ratio in twin pregnancies. Methods: Data analyzed were from 3 prospective studies: Prediction of Short-Term Outcome in Pregnant Women with Suspected Preeclampsia (PE...

..., blood pressure, pregnancy-associated plasma protein A and placenta growth factor, crown rump length, and uterine artery pulsatility index, for the prediction of preeclampsia in a high-risk population in the Netherlands. Methods: This is a prospective cohort including nulliparous women and women...

...Elisa Llurba; Miriam Bella; Jorge Burgos; Edurne Mazarico; María Dolores Gómez-Roig; Raül De Diego; Txanton Martínez-Astorquiza; Jaume Alijotas-Reig; María Ángeles Sánchez-Durán; Olga Sánchez; Elena Carreras; Lluís Cabero Background: Preeclampsia (PE) and intrauterine growth restriction (IUGR...

...Kasper Pihl; Steen Sørensen; Finn Stener Jørgensen Objective: To evaluate the performance of maternal risk factors (BMI and mean arterial pressure [MAP]) and first-trimester maternal serum markers in the early prediction of preeclampsia (PE) in nulliparous women. Material and Methods...

... of 6,366 women were included in the study after excluding cases with abnormal karyotype, major fetal abnormalities, or termination of pregnancy. There were 88 cases of preeclampsia (PE) (1.4%). Logistic regression was performed including maternal and fetal characteristics. Short FDL at 19–22 weeks...

... developed preeclampsia (PE) alone (13 were <34 weeks’ gestation), 16 had intrauterine growth restriction (IUGR) alone (12 were <34 weeks), 42 had both IUGR and PE (22 were <34 weeks), and 15 had an iatrogenic preterm delivery (PTD; 6 were <34 weeks). Twenty-one were unaffected and delivered...

... and compared between the PMD group (the women who developed preeclampsia or intrauterine growth restriction) and the non-PMD group (the women who remained healthy throughout pregnancy and 3 months postpartum) using the receiver-operating characteristic curves. Logistic regression was used to compare predictive...

... weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth. Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide...

...Amélie Boutin; Suzanne Demers; Cédric Gasse; Yves Giguère; Amélie Tétu; Geneviève Laforest; Emmanuel Bujold Background: First-trimester maternal serum markers have been associated with preeclampsia (PE). We aimed to evaluate the performance of first-trimester placental growth factor (PlGF...

... prediction models for the risk of preeclampsia (PE) based on routinely collected maternal predictors. Moreover, the potential utility of the best-performing models in clinical practice was evaluated. Material and Methods: Ten prediction models were systematically selected from the literature. We performed...

...Marie Lémery Magnin; Victor Fitoussi; Nathalie Siauve; Laetitia Pidial; Daniel Balvay; Gwennhael Autret; Charles André Cuenod; Olivier Clément; Laurent Julien Salomon Purpose: To evaluate placental function and perfusion in a rat model of preeclampsia infused with L-nitro-arginine methyl ester (L...

...Nieves L. González-González; Enrique González Dávila; Erika Padrón; Marina Armas Gonzalez; Walter Plasencia Introduction: We evaluated the utility of placental volume and three-dimensional (3D) vascular flow indices to predict early and late preeclampsia. Material and Methods: In 1,004 pregnancies...

...Eran Weiner; Ohad Feldstein; Letizia Schreiber; Ehud Grinstein; Elad Barber; Ann Dekalo; Jacob Bar; Michal Kovo Objective: To compare placental histopathological lesions and pregnancy outcomes in singleton and twin pregnancies complicated by preeclampsia (PE). Methods: Maternal characteristics...

... [PP13]) promoter DNA polymorphisms was evaluated in predicting preeclampsia (PE), given PP13's effects on hypotension, angiogenesis, and immune tolerance. Methods: First-trimester plasma samples (49 term and 18 intermediate) of PE cases matched with 196 controls were collected from King's College...