...Elisa Montaguti; Josefina Diglio; Benedetta Petrachi; Viola Arosio; Marta Fiorentini; Marta Cavalera; Anita Pellegrino; Silvia Amodeo; Jacopo Lenzi; Gianluigi Pilu Introduction: The measurement of nuchal translucency (NT) is crucial for assessing risk of aneuploidies in the first trimester. We...

... age, nuchal translucency, nasal bone, beta-hCG, and PAPP-A were evaluated. Screen positivity was defined as either a high risk after FT screening or a cfDNA test indicating a high-risk result. An inconclusive cfDNA test was also considered as screen positive. Results: The search of the database...

... , Sharland   GK , Snijders   RS , Nicolaides   KH . Increased nuchal translucency at 10–14 weeks of gestation as a marker for major cardiac defects . Ultrasound Obstet Gynecol . 1997 ; 10 : 242 – 6 . 10.1046/j.1469-0705.1997.10040242.x 14. Ghi   T , Huggon   I , Zosmer   N...

... for counselling the parents and preparing them for necessary interventions in case a complication arises. Objectives: The aim of our study was to assess the role of discordant crown-rump length (dCRL), discordant nuchal translucency (dNT), and discordant abdominal circumference (dAC) measurements in isolation...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cleft palate Fetal abnormalities First trimester Nuchal translucency...

... with isolated CLP and 302 consecutively assessed normal controls. The PMD values in fetuses with isolated CLP and normal controls were compared. Results: Firstly, 5 out of 6 referred pregnancies with isolated CLP were detected prospectively using the midsagittal view for measurement of nuchal translucency due...

... is an increased nuchal translucency. Iliescu et al. [ 26 ] evaluated 5,472 unselected patients with a 0.54% prevalence of cardiac defects ( n = 30). The authors reported that 8.7% of fetuses with increased nuchal translucency had major cardiac anomalies, a result almost 10 times higher than fetuses with normal...

...Asma Khalil; Negar Mahmoodian; Abhijit Kulkarni; Tessa Homfray; Aris Papageorghiou; Amar Bhide; Basky Thilaganathan Objectives: The aim was to investigate aneuploidy detection using an approach based on nuchal translucency (NT) and non-invasive prenatal testing (NIPT). Methods: This was a cohort...

... ultrasound-based protocols. To investigate whether maternal age (MA) has an impact on the efficacy of the ultrasound-based screening methods. Methods: In a prospective study, 6,265 patients were examined. Two ultrasound-based risk calculation protocols were applied: ‘NT' (based on nuchal translucency...

... or nuchal translucency between both age groups, nor in mean maternal age between the different gestational weeks in either age group. Discussion: Early serum sampling (<11 weeks) resulted in higher screening performance. The impact of the increase in the FPR was highest in women ≥36 years. m.engels...

... for fetal outcome. Results: The study population was divided into four groups according to the screening strategy performed. The combination of maternal serological biochemistry and nuchal translucency measurement had a 66.7% detection rate of trisomy 21. Addition of nasal bone status increased...

...Joachim Van Keirsbilck; Veerle Dewulf; Kristel Van Calsteren; Luc De Catte Objective: To assess the reproducibility and feasibility of automated nuchal translucency (NT) measurement (Volume NT©) in comparison to the two-dimensional (2D) manual approach. The Volume NT technique reveals the correct...

...Chiara Barone; Sebastiano Bianca Introduction: Several authors have reported on pregnancy outcomes associated with enlarged nuchal translucency (NT) in cases of spinal muscular atrophy (SMA), and thus, thickened NT has been considered a possible early ultrasound scan sign of SMA. The purpose of our...

.... Absent corpus callosum Nonchromosomal abnormalities Midsagittal view Nuchal translucency First-trimester screening The bias (mean difference) and 95% LOA between paired measurements of midbrain and falx diameters by two different operators are shown in table 3 . A paired t test to assess...

... and in combination with fetal nuchal translucency (NT) thickness and serum free β-hCG and PAPP-A was estimated. Results: In euploid pregnancies there was a bimodal distribution of DV PIV with a dominant crown-rump length (CRL)-dependent part, accounting for around 97% of cases in Caucasians and around 93% in Afro...

...Pranav Pandya; David Wright; Argyro Syngelaki; Ranjit Akolekar; Kypros H. Nicolaides Objective: To investigate whether measurement of maternal serum placental growth factor (PLGF) can improve the performance of first-trimester combined screening for trisomy-21 by fetal nuchal translucency (NT...

... plasma protein-A (PAPP-A) at 9 +0 –13 +6 weeks’ gestation. Methods: In singleton pregnancies attending for routine care, serum-free β-hCG and PAPP-A were measured at 9 +0 –13 +6 weeks’ gestation and fetal nuchal translucency was measured at 11 +0 –13 +6 weeks. The population included 27,908 chromosomally...

...Foteini E. Bredaki; David Wright; Pedro Matos; Argyro Syngelaki; Kypros H. Nicolaides Objective: To investigate the potential value of adding maternal serum alpha-fetoprotein (AFP) to free β-human chorionic gonadotropin (β-hCG) and PAPP-A and fetal nuchal translucency (NT) thickness in first...

... to in the content or advertisements. First-trimester screening Trisomy 21 Free β-hCG PAPP-A Nuchal translucency Original Paper Fetal Diagn Ther 2011;30:194 202 DOI: 10.1159/000328710 Received: April 4, 2011 Accepted after revision: April 26, 2011 Published online: June 25, 2011 First-Trimester...

... age-related risk keeps the false-positive rate low in younger women and increases the detection rate in older women. First trimester Nuchal translucency Free β-hCG PAPP-A Maternal age 20 12 2010 5 03 2011 23 6 2011 © 2011 S. Karger AG, Basel 2011 Copyright / Drug...