...Elisa Montaguti; Josefina Diglio; Benedetta Petrachi; Viola Arosio; Marta Fiorentini; Marta Cavalera; Anita Pellegrino; Silvia Amodeo; Jacopo Lenzi; Gianluigi Pilu Introduction: The measurement of nuchal translucency (NT) is crucial for assessing risk of aneuploidies in the first trimester. We...

... and maxilla in the first trimester of pregnancy. Methods: Retrospective analyses were performed of ultrasonographic images of nuchal translucency obtained during the first trimester of pregnancy (11–13 +6 weeks) from 45 fetuses with a cleft palate later confirmed following parturition or induced labor (cases...

...Lixia Shen; Daljit S. Sahota; Piya Chaemsaithong; Wing Ting Tse; Man Yan Chung; Jeffery Ka Him Ip; Tak Yeung Leung; Liona Chiu Yee Poon Introduction: This study aimed to identify risk factors among maternal characteristics, obstetric history, and first trimester preeclampsia-specific biomarkers...

...Cristina Trilla; Josefina Mora; Francesca Crovetto; Fàtima Crispi; Eduard Gratacos; Elisa Llurba; on behalf of the KidsCorona Pregnancy COVID-19 Group Objective: Second- and third-trimester SARS-CoV-2 infections may have an increased risk of obstetric complications. However, data on first-trimester...

... medullaris (CM) at the first trimester 3D ultrasound in a cohort of structurally normal fetuses. Methods: This was a multicenter prospective study involving a consecutive series of structurally normal fetuses between 11 and 13 weeks of gestation (CRL between 45 and 84 mm). All fetuses were submitted to 3D...

...Charlotte Kvist Ekelund; Line Rode; Ann Tabor; Jon Hyett; Andrew McLennan Objective: The study aimed to investigate the association between placental growth factor (PlGF) and adverse obstetric outcomes in a mixed-risk cohort of pregnant women screened for preeclampsia (PE) in the first trimester...

... the initial diagnosis at early fetal echocardiography through the gestation and to evaluate the impact of the first-trimester scan on the outcome. Methods: We identified cases of TOF or outlet VSD with am diagnosed before 16 weeks’ gestation. For all cases, prenatal data and pregnancy outcomes were evaluated...

...Kasper Pihl; Steen Sørensen; Finn Stener Jørgensen Objective: To evaluate the performance of maternal risk factors (BMI and mean arterial pressure [MAP]) and first-trimester maternal serum markers in the early prediction of preeclampsia (PE) in nulliparous women. Material and Methods...

... for the mother and the newborn. Objectives: To identify risk factors for PPRoM and develop a model for first-trimester prediction of risk of PPRoM. Methods: A retrospective analysis of a series of women who had first-trimester (11–13 +6 weeks) screening for aneuploidy and pre-eclampsia and delivered in the same...

...Salma Jabak; Trisha V. Vigneswaran; Marietta Charakida; Taner Kasapoglu; Jader de Jesus Cruz; John M. Simpson; Vita Zidere Background: In the first trimester, ultrasound confirmation of normal or abnormal cardiac anatomy is difficult. B-mode and colour flow Doppler (CFD) are used to assess...

... marker for the prediction of placental-related adverse pregnancy outcomes, supporting an argument for the prediction of risk at 11–13 +6 weeks’ gestation. The meanUAPI was calculated by adding the left and right PI and dividing by 2. For participants who returned for first-trimester screening at 11...

...Karl Oliver Kagan; Vanessa Maier; Jiri Sonek; Harald Abele; Kai Lüthgens; Maximilian Schmid; Philipp Wagner; Markus Hoopmann Objective: To determine whether screening for trisomy 21 based on first-trimester combined screening (FTCS) with assessment of nasal bone (NB), tricuspid flow (TCF...

...Valentina De Robertis; Georgios Rembouskos; Tiziana Fanelli; Carmela Votino; Paolo Volpe Objective: To evaluate the presence of maxillary gap (MG) and abnormal retronasal triangle (RT) as markers of cleft palate (CP) with and without cleft lip in the first trimester and to assess their association...

...Amélie Boutin; Suzanne Demers; Cédric Gasse; Yves Giguère; Amélie Tétu; Geneviève Laforest; Emmanuel Bujold Background: First-trimester maternal serum markers have been associated with preeclampsia (PE). We aimed to evaluate the performance of first-trimester placental growth factor (PlGF...

...Linda J.E. Meertens; Hubertina C.J. Scheepers; Sander M.J. van Kuijk; Robert Aardenburg; Ivo M.A. van Dooren; Josje Langenveld; Annemieke M. van Wijck; Iris Zwaan; Marc E.A. Spaanderman; Luc J.M. Smits Introduction: This study assessed the external validity of all published first trimester...

... combinations of the relevant medical subject heading for “fetus,” “tricuspid regurgitation,” and “first trimester.” The outcomes explored were prevalence of TR in an euploid population, strength of association between TR and CHD, and predictive accuracy of TR for CHD in euploid fetuses. Summary estimates...

...Beatrice Mosimann; Sofia Amylidi-Mohr; Katrin Höland; Daniel Surbek; Lorenz Risch; Luigi Raio Objective: The aims of this study were to test whether the performance of first-trimester placental growth factor (PlGF) in screening for preterm preeclampsia (PE) is gestational age dependent...

... distance, and prefrontal space ratio (PFSR) in the first trimester of pregnancy, develop normal ranges, and evaluate these markers in abnormal fetuses. Methods: All measurements were performed on stored images by two operators. Feasibility, interoperator agreement, and prediction intervals were calculated...

...Alvaro Sepúlveda-Martínez; Maritza Garrido; Egardo Caamano; Margarita Vega; Carmen Romero; Mauro Parra-Cordero Objective: The aim of this study was to determine the role of nerve growth factor (NGF) in the first-trimester screening for preeclampsia (PE). Methods: Uterine artery Doppler (UtAD...

... with high uptake of combined first-trimester screening (cFTS). Material and Methods: This was a nationwide population-based study including infants born in 2009-2012. Information from the cFTS, fetal karyotype results and pregnancy outcome was obtained from the Danish Fetal Medicine Database on all women...