... hydrocephalus often results in irreversible and severe damage to the brain despite postnatal interventions. The potential for prenatal intervention to mitigate these deleterious effects underscores the importance of a suitable animal model. We aimed assess the results of an ultrasound-guided transuterine...

... animal models allow for the evaluation of short-term efficacy of these products, they are limited in allowing researchers to evaluate long-term safety due to the inherent associated morbidity. Other standard animal models to evaluate safety and potential tumorigenicity of biologic products, including NOD...

... an animal model to study the growth factors found within amniotic fluid and inform design of a synthetic fluid to optimize fetal development. Methods: We designed a model of amniotic fluid exchange within the pregnant rabbit, continuously removing the natural fluid from around 2 fetuses per doe...

...Melissa Vanover; Christopher Pivetti; Laura Galganski; Priyadarsini Kumar; Lee Lankford; Douglas Rowland; Zachary Paxton; Bailey Deal; Aijun Wang; Diana Farmer Introduction: The surgically induced fetal lamb model is the most commonly used large animal model of myelomeningocele (MMC) but is subject...

... ]. However, the neurodevelopmental effect of early EE has never been evaluated in an animal model of IUGR. At the neonatal period (at +1 postnatal day), general motor skills, reflexes, and sensitivity were evaluated (controls: n = 24; IUGR animals: n = 14; treated IUGR animals: n = 15...

.... Undernutrition Animal model Behavior Brain networks Fetal growth restriction Placental insufficiency Fetal growth restriction (FGR) has been related to neurobehavioral problems during the childhood period [ 1,2 ] that also persist in the long term [ 3,4 ]. Interestingly, long-term follow-up studies...

... weights. These results indicate the importance of PP13 carbohydrate binding for inducing vascular remodeling and improving reproductive outcome. Future studies are needed to determine whether beneficial effects would be evident in animal models of preeclampsia or in women predisposed to the development...

... proceed with caution until further data are obtained. 17 03 2010 2 09 2010 20 10 2010 Ureteropelvic junction obstruction Fetal hydronephrosis Radiological and pathological study Animal model Original Paper Fetal Diagn Ther 2010;28:196 200 DOI: 10.1159/000320966 Received: March...

...E. Eixarch; F. Figueras; E. Hernández-Andrade; F. Crispi; A. Nadal; I. Torre; S. Oliveira; E. Gratacós Introduction: To describe an animal model of growth restriction based on selective ligature of uteroplacental vessels in the pregnant rabbit. Material and Methods: Two experimental protocols (+21...

...B. de Keersmaecker; M. Vloeberghs; Y. Ville Objective: The aim of this study was to create an animal model of obstructive ventriculomegaly in the fetal lamb at 78 days of gestation by injecting maternal blood into the lateral ventricles under ultrasound guidance. Methods: An endoscope of 1.2 mm...

...S. Beaudoin; P. Barbet; F. Bargy Researchers involved in the field of congenital malformations are often forced to work on an animal model. Both accurate description of its normal development and comparative staging with human development will be mandatory. To complete the lacking medical...

... Cardiologia, Sa o Paulo, Brazil Key Words Fetal surgery W Myelomeningocele W Spina bifida W Rabbit, prenatal W Animal model Abstract Objective: To evaluate the fetal survival rate using a modified technique to surgically create a myelomeningocele-like defect in a rabbit model. Methods: Six white New...

... in postnatal animals. Conclusions: This animal model and vector delivery method may be useful for evaluating gene transfer to the fetus with viral and nonviral vectors. Further modifications of the adenoviral vector to reduce immunogenicity may enhance the duration of expression. 4 11 1998 1998...

..., Paris, and c Laboratoire d Anatomie et Organogenèse UFR Cochin & UFR Biomédicale des Saints-Pères, Université Paris V, France Surgical Approach of an Early Mammalian Embryo: The Rabbit Model OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO Key Words Animal model Congenital malformations Experimental...