...Philip W. Wertz Lipids in the intercellular spaces of the stratum corneum provide the permeability barrier of the skin. The primary function of the barrier is to prevent water loss to the environment. Secondarily, the barrier limits or prevents the penetration of potentially toxic substances...

...A.V. Rawlings Water is absolutely essential for the normal functioning of the skin and especially the stratum corneum (SC). However, as the SC is continuously exposed to varying humidities, maintenance of water within the tissue is crucial. Under most circumstances water present within the SC...