... Essalud, Cusco, Peru Key Words Corneodesmosome Pitted keratolysis Microorganisms Keratohyalin granules Stratum corneum the bacteria alter the structure of both the corneodesmosomes and the keratohyalin granules. The latter appeared more resistant to the normal processing of pro laggrin inside...

... Monitoring the Penetration and Distribution of Topically Applied Formulations through the Skin in Relation to the Skin Protein/Lipid Morphological Characteristics Patrick Garidel Institute of Physical Chemistry, Martin-Luther-University Halle/Wittenberg, Halle/Saale, Germany Key Words Stratum corneum Lipid...

...Genji Imokawa In order to clarify the mechanisms underlying the surfactant-induced dehydration of the stratum corneum (SC), we first examined the constitutive water-holding function of the SC by removing intercellular lipids as well as hygroscopic materials from intact human SC. The dehydration...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Dry skin Xerosis Climate Stratum corneum Natural moisturizing factor Exog Dermatol...

...Emmanuelle Uhoda; Claudine Piérard-Franchimont; Béatrice Debatisse; Xuemin Wang; Gérald E. Piérard Background: The stratum corneum (SC) structure and functions are altered by surfactants. Enhancing the repair mechanisms is a goal for some skin care formulations. Aim: To design an experimental...

...Myeong Jun Choi; Hongbo Zhai; Harald Löffler; Frank Dreher; Howard I. Maibach The stratum corneum provides the first barrier to the percutaneous absorption of drugs as well as regulating water loss. This barrier limits the topical/transdermal delivery of drugs and biological macromolecules...

... measured through dermatomed skin are higher than those heretofore measured through full-thickness skin, epidermal tissue or stratum corneum; (c) both the nickel salt and soap appear to diffuse primarily via appendages; (d) the cause for the pronounced immune response to nickel in contact with the skin...

...Emmanuelle Uhoda; Marc Paye; Gérald E. Piérard Surfactant-based skin care products can induce minimal to severer alterations of the human stratum corneum (SC). These changes can be conveniently assessed using electrometric devices. Four different surfactant-based solutions were applied...

...Joachim W. Fluhr; Peter M. Elias Although the acidic surface pH of the skin has been known for over a century, the stratum corneum (SC) pH gradient has been discovered only recently. After removal of SC layers with sequential tape strips, in humans, surface pH starts at 4.5–5.3, increasing by about...

...Ken-ichiro O’goshi; Mikiko Okada; Makiko Iguchi; Hachiro Tagami The functional deficiencies of the stratum corneum (SC) have been well documented in the skin of atopic dermatitis (AD) patients. AD tends to affect certain predilection areas chronically such as the face, neck and the flexural folds...

...Claudine Piérard-Franchimont; Gérald E. Piérard On clinical grounds, the so-called dry skin corresponds in reality to a rough, sometimes flaky and scaly stratum corneum. The spectrum of xerotic disorders is quite large encompassing diverse aetiologies and physiopathological pathways. The clinical...

...., Lafayette, Calif., bDepartment of Dermatology, UCSF School of Medicine, San Francisco, Calif., and cNiPERA, Durham, N.C., USA Key Words Nickel W Alloys W Oxidation W Sweat W Stratum corneum W Diffusion Abstract Skin exudates can corrode (oxidize) and possibly dissolve metal surfaces they contact...

... volunteers of different age groups. Biophysical noninvasive measurements, including transepidermal water loss (TEWL) as a parameter for the barrier function of the stratum corneum (SC), high-frequency conductance as a parameter for the hydration state of the SC, temperature, color and casual surface lipid...