... such regimen is cryotherapy. Methods: Between 1976 and 1989, 1,250 patients were seen with newly diagnosed prostate cancer. Sixty-six patients of stages T(1c) (n = 3), T(2a)(n = 32), T(2b) (n = 9), T(2c) (n = 11), T(3a) (n = 4), T(3b) (n = 5) and T(3c) (n = 2) were treated by open perineal cryotherapy. Mean...

... Objective: The use of prostate-specific antigen (PSA) for prostatic cancer screening and the practical utility of the concept of PSA density are controversial. The aim this multicenter study was to assess the usefulness of PSA as a diagnostic procedure for prostate cancer in patients with urinary...

...Charles L. Bennett; Gretchen Chapman; Arthur S. Elstein; Sara J. Knight; Robert B. Nadler; Roohallah Sharifi; Tim Kuzel Background: Quality-of-life considerations are important in metastatic prostate cancer. In this study, we interviewed physicians and patients about their assessments...

...Wael A. Sakr; David J. Grignon In spite of the slow progression rates common to most prostate cancers, it is well recognized that a subset of patients will experience a more aggressive course with many losing their lives to this malignancy. As the number of patients diagnosed with prostate cancer...

... of detection with transrectal ultrasound and prostate-specific antigen(PSA) have resulted in a dramatic shift in the stage of disease at diagnosis. It is safe to say that in these countries the majority of prostate cancers are now being clinically diagnosed while still localized, and many organ-confined tumors...

...Gerald L. Andriole Objective: To identify which patients with prostate cancer are at high risk for local or distant recurrence after radical prostatectomy. Methods: Review of data from several historical and contemporary series of patients undergoing radical prostatectomy. Results: Patients...

...D.W.W. Newling The early recurrence of prostate cancer originally staged as locally more than T2 and nonmetastatic, cast doubts over the adequacy of the staging of this form of the disease. Monotherapy with curative intent, either by radical prostatectomy or radiotherapy, results in around half...

...Peter Ekman Pelvic lymph node dissection is a routine staging procedure in localized prostate cancer. It provides prognostic information, it influences the design of the subsequent therapeutic strategy and it provides information necessary to compare the results of various therapeutic strategies...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Prostate cancer Radical prostatectomy...

... and during treatment, together with various clinicopathological parameters, were measured retrospectively in 48 patients with newly diagnosed metastatic prostate cancer. The prognostic importance of these measurements was analyzed by both univariate and multivariate techniques. Results: PSA levels 2 months...

...Avi Stein; Mira Barak; Yoel Mecz; Raffael Rubinov; Aharon Lurie Objective: This study is based on promising results using the ratio of free/total (F/T) prostatic-specific antigen (PSA) for discrimination between benign prostatic hypertrophy and prostate cancer. We tried to determine the value of F...

... chain reaction (nested RT-PCR) to improve the staging of clinically localized prostate cancer. Methods: Nested PCR was performed on blood samples of 29 patients submitted to radical prostatectomy for clinically localized(T(1)-T(2)) prostate cancer. Nine patients with various benign urologie diseases...

... from 73 patients with clinically localized prostate cancer were studied. Tumor DNA ploidy pattern as measured by flow cytometry was correlated with the level of functional ER using the nuclear biopsy assay. Results: Forty-five percent of the tumors were DNA diploid, and 55% had an abnormal ploidy...

... to Predict Extracapsular Disease or Nodal Metastasis in Men with Newly Diagnosed, Previously Untreated Prostate Cancer A Multicenter Study Key Words Prostate-specific antigen Prostate cancer Gleason grade Stastistical analysis Abstract Objective: To draw nomograms for preoperative predictions...

...Jürgen Breul; Gerhard Jakse; Gerhard Forster; Alexander Lampel; Abolhassan Rohani; Rudolf Hartung Objectives: Results of cytotoxic chemotherapy for hormone-resistant prostate cancer are not impressive. One of the substances which seems to have a therapeutic benefit is 5-fluorouracil (5-FU...

... of the patients, so that PSA can be used to distinguish between prostate cancer and benign prostate hyperplasia (BPH). Material and Methods: Using specific ELISAs, total PSA and PSA complexed to ai-antichymotrypsin (complexed PSA) were determined in 237 BPH patients, 160 with histologically confirmed BPH and 77...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Prostate-specific antigen Benign prostatic hyperplasia Prostate cancer European...

... assay. The activity was assayed using the telomeric repeat amplification protocol and correlated with histological findings. Results: Of the total of 114 samples, 57 were obtained from 22 prostate cancer patients. Telomerase activity was detected in 66% (25/38) of the samples which were histologically...

...) in men with prostate cancer and (ii) to assess the pattern of plasma testosterone levels following each injection of GnRHa. Patients and Methods: 67 patients referred for prostate cancer not suitable for surgery were randomly allocated to two treatment regimens: 33 patients received 3.75 mg Trp i.m. at 4...

...K. Pummer; M. Lehnert; H.L. Seewann The standard palliative treatment for patients with advanced prostate cancer has for the past 50 years been androgen withdrawal. However, owing to the presence of hormone-insensitive cell clones, the benefits of this approach have now appeared to reach...