...Peter S. Nelson; Terrence P. Gleason; Michael K. Brower Objectives: To evaluate the potential application of chemoprevention strategies in prostatic intraepithelial neoplasia. Methods: Review of relevant literature on chemoprevention with emphasis on prostate cancer and premalignant lesions...

... of risk factors and epidemiological autopsy incidences, and have developed hypotheses to prevent clinical prostate cancer, therefore we should now be performing chemoprevention studies in time to save the next generation from unneeded treatment and healthcare deficits. 11 8 2017 1996...

...J. Trachtenberg Chemoprevention of prostate cancer is an attractive idea that appeals to many struggling with the treatment of this disease. Many details inherent in any preventive strategy must be considered before embarking on this course,no matter how seductive it may appear. Critical issues...

... low-fat, high-fibre diets which provide a rich supply of weak dietary oestrogens. These plant or phyto-oestrogens have been proposed as chemopreventive agents, particularly for Asian men and to a lesser extent, for vegetarian men also. The three principal classes of phyto-oestrogens...

... in biopsy specimens of the prostate warrants further search for concurrent invasive carcinoma. Androgen deprivation therapy and radiation therapy decrease its prevalence and extent, suggesting a role in chemoprevention. 16 4 2012 A short-term prospective, double-masked, placebo-controlled, phase...

...Maarten C. Bosland Animal models are crucial in preclinical efficacy testing of chemoprevention agents. The most feasible, realistic, and potentially effective target for prostate cancer chemoprevention is progression from prostatic intraepithelial neoplasia (PIN) to histologic cancer and from...

... for prostate cancer. An exciting approach lies in the possibility of chemoprevention to reverse the process of carcinogenicity and prevent prostate cancer by this route. Indeed, there are several very interesting ideas being tested at this moment. One major difficulty is the long length of time which can...

... in both groups of patients. This observation is most likely explained by an effect due to the diagnostic sextant biopsy equally affecting both groups of patients. Results from this study do not demonstrate a chemoprevention effect of 4-HPR on tissue-based SEBs at the dose given. 16 4 2012...

...K. Griffiths; M.S. Morton; L. Denis Isoflavonoids, flavonoids and lignans are natural oestrogenic compounds derived from soya, tea, fruits and vegetables and they have been proposed as chemopreventive agents in Asian men, in whom the incidence of prostate cancer is much lower than in men from...

...Peter Whelan Over several decades, in vitro experimental studies have demonstrated that retinoids effect the process of carcinogenesis and tend towards the alteration of cells back to more normal differentiation. This hypothesis has formed the basis of several chemopreventive studies in breast...

...Gary J. Kelloff; Ronald Lieberman; Vernon E. Steele; Charles W. Boone; Ronald A. Lubet; Levy Kopelovitch; Winfred A. Malone; James A. Crowell; Caroline C. Sigman Chemoprevention is the administration of agents to prevent induction and inhibit or delay progression of cancers. For prostate...

...Adrian P.M. van der Meijden In addition to the normal aspects of organizing clinical trials, the launch of a chemoprevention trial on prostate cancer needs extra effort. The sample size and duration of follow-up is so extensive that such a trial should be organized as an intergroup study...

... by MIB-1 antibody immunostaining [ 12 ]. This further underlines the resemblance of dysplastic cells of PIN with benign prostatic secretory cells. Chemoprevention of prostate cancer by reduction of androgen levels should act by elimination of PIN or by prevention of the transition of PIN to overt...

...Richard Sylvester; Laurence Collette The design and analysis of chemoprevention trials in prostate cancer is more complicated than that of an ordinary treatment efficacy trial. The following issues must be taken into account when designing prospective randomized chemoprevention trials: (1...

... in vivo screening of chemopreventive agents by using the prevalence and extent of HGPIN in the dog prostate as a surrogate endpoint biomarker. 16 4 2012 1999 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

...David L. McCormick; K.V.N. Rao The high incidence and long latent period of prostate cancer make it an ideal target for chemoprevention. We have evaluated a series of agents for chemopreventive efficacy using a model in which hormone-dependent prostate cancers are induced in the Wistar-Unilever (WU...

... in other organs, particularly the colon and breast [ 21, 22 ]. Evidence from epidemiologic studies, molecular and cellular studies of in vitro cell cultures, and animal models have prompted pilot studies to test chemopreventive and chemotherapeutic activity of vitamin D and analogs against breast and colon...

...Michael B. Sporn The magnitude of the problem of prostate cancer, and the failure of conventional chemotherapy and surgery to effect a marked diminution in the total number of deaths from this disease, now indicate that chemoprevention of prostatic carcinogenesis must be seriously considered. We...

...E.D. Crawford Serum prostate-specific antigen (PSA) is the most important tumor marker in oncology practice. It may assume a similar role in chemoprevention strategies. It is a simple and reproducible blood test that can both identify a high-risk cohort and provide meaningful information regarding...

... significant, potentially aggressive prostate cancer in African-American men. In this epidemiologically identifiable high-risk group, there is a potential opportunity for chemoprevention strategies in younger men with high-grade PIN. Similar studies were proposed by Bostwick [ 27 ]. This author...