Objective: To evaluate the effect of capsaicin, a powerful neurotoxin selective to afferent nerves, on contralateral testicular damage in ipsilateral testicular torsion. Methods: Forty male albino rats were randomly allocated into five groups. No operation was performed in group one. After intraperitoneal administration of 0.9% NaCl, rats underwent a sham operation in group 2 and testicular torsion in group 3. In groups 4 and 5 rats underwent sham operation and testicular torsion, respectively after intraoperitoneal capsaicin injection. Contralateral testes were harvested on the fifteenth day of the experiment and mean seminiferous tubular diameters and mean testicular biopsy scores were recorded for each testis. The values were compared through analysis of variance (ANOVA) with Turkey–Kramer multiple comparisons test and p values less than 0.05 were considered to be significant. Results: Mean testicular biopsy scores and mean seminiferous tubular diameters of group 5 was significantly higher than the group 3. There was no difference between the groups 1, 2, 4, and 5 when these two parameters are concerned. Conclusion: Capsaicin effectively prevents contralateral testicular damage encountered following ipsilateral testicular torsion. The inhibition of afferent impulses from the ipsilateral testis under distress prevents contralateral testicular injury, and provides additional data to support the role of an autonomic reflex arc in contralateral testicular injury.

Anderson JB, Williamson RCN: Fertility after torsion of the spermatic cord. Br J Urol 1990; 65:225–230.
Nagler HM, White RV: The effect of testicular torsion on the contralateral testis. J Urol 1982; 128:1343–1348.
Bartsch G, Frank ST, Marberger H, Mikuz G: Testicular torsion: late results with special regard to fertility and endocrine function. J Urol 1980;124:375–378.
Tanyel FC, Büyükpamukçu N, Hiçsönmez A: Contralateral testicular blood flow during unilateral testicular torsion. Br J Urol 1989;63: 522–524.
Kõzõlcan F, Bernay I, Tanyel FC, Büyükpamukçu N, Bekdik C, Hiçsönmez A: Ipsilateral and contralateral blood flows during testicular torsion by 133Xe clearance technique. Int Urol Nephrol 1992;24:515–520.
Akgür F, Kõlõnç K, Tanyel FC, Büyükpamukçu N, Hiçsönmez A: Ipsilateral and contralateral testicular biochemical changes after unilateral testicular torsion and detorsion. Urology 1994; 44:413–418.
Kolettis PN, Stowe NT, Inman SR, Thomas AJ Jr: Acute spermatic cord torsion alters the microcirculation of the contralateral testis. J Urol 1996;155:350–354.
Salman AB, Mutlu S, Iskit AB, Güç MO, Mutlu M, Tanyel FC: Hemodynamic monitorization of contralateral testis during unilateral testicular torsion describes the mechanism of damage. Eur Urol 1998;33:576–580.
Çiftçi AO, Müftüoğlu S, Çakar N, Tanyel FC: Histological evidence of decreased contralateral testicular blood flow during ipsilateral testicular torsion. Br J Urol 1997;80:783–786.
Thomas WEG, Cooper MJ, Crane GA, Lee G, Williamson RCN: Testicular exocrine malfunction after torsion. Lancet 1984;ii:1357– 1359.
Madarikan BA: Testicular salvage following spermatic cord torsion. J Pediatr Surg 1987;22: 231–234.
Hagen P, Buchholz M, Eigenmann J, Bandhauer K: Testicular dysplasia causing disturbance of spermiogenesis in patients with unilateral torsion of testis. Urol Int 1992;49:154– 157.
Laor E, Fisch H, Tennenbaum S, Sesterhenn I, Mostofi K, Reid RE: Unilateral testicular torsion: Abnormal histological findings in the contralateral testis: Cause or effect? Br J Urol 1990;65:520–523.
Anderson JB, Cooper MJ, Thomas WEG, Williamson RCN: Impaired spermatogenesis in testis at risk of torsion. Br J Surg 1986;73: 847–849.
Salman AB, Okur DH, Tanyel FC: DNA flow cytometry reveals depressed spermatogenetic activity in the contralateral testis within 24 h of ipsilateral spermatic cord torsion independently of the presence of the testis and epididymis. Eur Urol 1998;34:377–381.
Karagüzel G, Tanyel FC, Kõlõnç K, Büyükpamukçu N, Hiçsönmez A: The preventive role of chemical sympathectomy on contralateral testicular hypoxic parameters encountered during unilateral testicular torsion. Br J Urol 1994;74:507–510.
Karnak I, Gedikoğlu G, Tanyel FC, Büyükpamukçu N, Hiçsönmez A: The effects of chemical sympathectomy on contralateral testicular histology, fertility and fecundity in the unilateral abdominal testis. Br J Urol 1996;77:580– 584.
Oğuzkurt P, Okur H, Tanyel FC, Büyükpamukçu N, Hiçsönmez A: The effects of vasodilatation and chemical sympathectomy on spermatogenesis after unilateral testicular torsion: a flow cytometric DNA analysis. Br J Urol 1998;82:104–108.
Chancellor MB, De Groat WC: Intravesical capsaicin and reiniferatoxin therapy: Spicing up the ways to treat the overactive bladder. J Urol 1999;162:3–11.
De Seze M, Wiart L, Ferriere JM, De Seze MP, Joseph PA, Barat M: Intravesical instillation of capsaicin in urology: a review of the literature. Eur Urol 1999;36:267–277.
Tanyel FC, Ayhan A, Büyükpamukçu N, Hiçsönmez A: The testes after unilateral incarcerated inguinal hernia in prepubertal rats. Turk J Pediatr 1989;31:263–269.
Andõran F, Okur DH, Kõlõnç A, Gedikoğlu G, Kõlõnç K, Tanyel FC: Do experimentally induced ipsilateral testicular torsion, vas deferens obstruction, intraabdominal testis or venous obstruction damage the contralateral testis through a common mechanism. BJU Int 2000;85:330–335.
Miao FJ, Janig W, Green PG, Levine JD: Inhibition of bradykinin–induced plasma extravasation produced by noxious cutaneous and visceral stimuli and its modulation by vagal activity. J Neurophysiol 1997;78:1285–1292.
Hiura A: Neuroanatomical effects of capsaicin on primary afferent neurons. Arch Histol Cytol 2000;63:199–215.
Zhue FX, Zhang XY, Olszevski MA, Robinson NE: Mechanisms of capsaicin–induced relaxation in equine tracheal smooth muscle. Am J Physiol 1997;273:L997–L1001.
White CB, Roberts AM, Joshua IG: Arteriolar dilation mediated by capsaicin and calcitonin gene–related peptide in rats. Am J Physiol 1993;265:H1411–1415.
Leung AYH, Leung PY, Cheng–Chew SB, Wong PYD: The role of calcitonine gene related peptide in the regulation of anion secretion by the rate and human epididymis. J Endocrinol 1992;133:259–268.
Tsuda K, Tsuda S, Golstein M, Nishio I, Masuyama Y: Calcitonin gene–related peptide in noradrenergic transmission in rat hypothalamus. Hypertension 1992;19:639–642.
Tanyel FC, Aydõn A, Banoğlu E, Işımer A, Büyükpamukçu N: Noradrenaline and nitrite–nitrate concentrations in the contralateral testes during ipsilateral spermatic cord torsion in the presence or absence of a testis and epididymis. BJU Int 1999;83:833–836.
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