Objective: In this study, we evaluated the urological complications and their consequences after renal transplantation in children. Materials and Methods: A retrospective study was performed concerning urological complications after kidney transplantation in children at the University Medical Center St Radboud Nijmegen from August 1977 until July 1999. The mean age of the cadaver kidney donors was 23.2 (range 1–74.3) years. Results: In this period 146 children received 183 renal allografts. Twenty–four urological complications (13.1%) were noted in 23 patients. Urinary leakage was seen in 8 cases (4.4%) and a ureteral stenosis was present in 7 cases (3.8%), 5 patients developed stones (2.7%) and 4 severe lymph leakage needing surgical treatment (2.2%). In 3 patients the urological complication induced graft loss. In cadaver kidneys from donors younger than 5 years there was no significantly increased complication rate in comparison to older cadaver kidneys [2/32 (6.3%) versus 16/125 (12.2%)]. In a subgroup of 24 patients treated for severe posterior urethral valves the complication rate was not significantly increased in comparison to the others (8.3% in the group with posterior urethral valves against 13.7% in the group without). Conclusions: Urological complications are a small threat for graft function and the results are comparable with earlier studies. Routine ultrasound can be important for early detection of problems in the postoperative period. A close observation in the postoperative care and good collaboration between pediatric nephrologist and urologist is mandatory. Sometimes, early intervention can be undertaken with the possibility of saving graft function and reducing morbidity.

1.
Najarian JS, Frey DJ, Matas AJ, Gillingham KJ, So SKS, Cook M, Chavers B, Mauer SM, Nevins TE: Renal transplantation in infants. Ann Surg 1990;212:353–365.
2.
Valdès R, Munoz R, Bracho E, Gordillo G, Velazquez L, Nieto J: Surgical complications of renal transplantation in malnourished children. Transplant Proc 1994;26:50–51.
3.
Sheldon CA, Chuchill BM, Khoury AE, McLorie GA: Complications of surgical significance in pediatric renal transplantation. J Pediatr Surg 1992;27:485–490.
4.
Mesrobian HG, Miller CG, Hatchett RL, Azizkhan RG, Lacey SR: Modified extravesical ureteral reimplantation in paediatric renal transplantation: 5 years experience. J Urol 1992;147:1340–1342.
5.
Rigg KM, Proud G, Ross Taylor RM: Urological complications following renal transplantation. A study of 1,016 consecutive transplants from a single centre. Transpl Int 1994;7:120– 126.
6.
Zaontz MR, Hatch DA, Firlit CF: Urological complications in pediatric renal transplantation: Management and prevention. J Urol 1988;140:1123–1128.
7.
Weibull H, Husberg B, Gäbel H, Fjeldborg O, Ladefoged J, Lindholm A, Monn E, Onmell Persson M, Salmela K, Wahlberg J: Renal transplantation in Nordic children during two decades. A retrospective study. Clin Transplant 1988;2:275–284.
8.
Chantler C, Carter JE, Bewick M, Counahan R, Cameron JS, Ogg CS, Williams DG, Winder E: 10 years’ experience with regular haemodialysis and renal transplantation. Arch Dis Child 1980;55:435–445.
9.
Wisnia LG, Chatterjee SN, Drago JR: Urologic complications in renal transplantation. Dial Transplant 1980;9:482–486.
10.
Mundy AR, Podesta ML, Bewick M, Rudge CJ, Ellis FG: The urological complications of 1,000 renal transplants. Br J Urol 1981;53: 397–402.
11.
Lashley DB, Barry JM, Demattos AM, Lande MB, Mowry JA: Kidney transplantation in children: A single center experience. J Urol 1999;161:1920–1925.
12.
Koo HP, Bunchman TE, Flynn JT, Punch JD, Schwartz AC, Bloom DA: Renal transplantation in children with severe lower urinary tract dysfunction. J Urol 1999;161:240–245.
13.
Oosterhof GON, Hoitsma AJ, Witjes JA, Debruyne FMJ: Diagnosis and treatment of urological complications in kidney transplantation. Urol Int 1992;49:99–103.
14.
Popli S, Leehey DJ, Giacciano JL, Ramamurthy S, Soundararajan R, Ing TS: Obstructions to venous outflow from the left lower extremity after renal transplantation. Clin Nephrol 1996;45:236–240.
15.
Oosterhof GON, Hoitsma AJ, Debruyne FMJ: Antegrade percutaneous dilatation of ureteral strictures after kidney transplantation. Transpl Int 1998;2:36–39.
16.
Bermeijer JH, Nijman R, Kalkman E, Nauta J, Wolff ED, Molenaar JC: Stenting of the ureterovesical anastomosis in pediatric renal transplantation. Transpl Int 1990;3:146–148.
17.
Ehrlich RM, Smith RB: Surgical complications of renal transplantation. Urology 1977; 10:43–56.
18.
Guest G, Tete MJ, Buerton D, Broyer M: Lithiase urinaire après transplantation renale. Experience d’un centre pediatrique. Arch Fr Pédiatr 1993;50:15–19.
19.
Greif F, Dreznick Z, Jacob ET: Calculus in 16–year–old cadaveric kidney transplant: A unique case and literature review. Nephron 1990;55: 423–428.
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