Three-hundred and three consecutive newly detected bladder tumours were studied by DNA flow cytometry. The tumours were classified as diploid or aneuploid. The degree of aneuploidy was determined and the existence of more than one aneuploid cell peak was considered. Proliferative properties of the tumours were assessed from the proportion of S-phase cells. The majority of grade 1 tumours were diploid and grade 3 tumours aneuploid with few exceptions, while half of the grade 2 tumours were diploid or aneuploid. Ta tumours differed from T j tumours in that they had a lower frequency of aneuploid cases, a lower proliferation rate and fewer cases with more than one aneuploid cell line. The proportion of S-phase cells increased with grade and stage. More than one aneuploid cell line was most frequently found for muscle-invasive tumours and in carcinoma in situ. A subdivision of bladder tumours based on the DNA pattern is presented.

Keywords:
Flow DNA analysis, Bladder carcinoma
This content is only available via PDF.
1985
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.