...Lisa Volke; Kerstin Krause The recruitment and activation of energy-consuming brown adipocytes is currently considered as potential therapeutic approach to combat obesity. Thyroid hormones (TH) significantly contribute to full thermogenic capacity of brown adipocytes. A number of recent studies...

...Doreen Braun; Ulrich Schweizer Introduction: The monocarboxylate transporter 8 (MCT8; SLC16A2) is a specific transporter for thyroid hormones. MCT8 deficiency, formerly known as the Allan-Herndon-Dudley syndrome, is a rare genetic disease that leads to neurological impairments and muscle weakness...

... Thyronamines Thyroid hormone Metabolism Thermoregulation Body temperature Brown adipose tissue Deutsche Foschungsgemeinschaft (DFG) 10.13039/501100001659 Thyronamines are decarboxylated and deiodinated metabolites of thyroid hormone [ 1, 2 ]. The most -prominent member of this group...

...Barbara A. Demeneix Thyroid hormone regulates vital processes in early brain development such as neuronal stem cell proliferation, migration, and myelination. The fetal thyroid is not fully functional until mid-pregnancy (18–20 weeks), so placental transfer of maternal thyroid hormones during early...

...Zhi Zhang; Anita Boelen; Andries Kalsbeek; Eric Fliers Thyroid hormone (TH) plays a key role in regulating body temperature in mammals. Cold exposure stimulates the hypothalamus-pituitary-thyroid (HPT) axis at the hypothalamic level by activating hypophysiotropic thyrotropin-releasing hormone (TRH...

...Lisbeth Harder; Nancy Schanze; Assel Sarsenbayeva; Franziska Kugel; Josef Köhrle; Lutz Schomburg; Jens Mittag; Carolin S. Hoefig Objectives: Thyronamines are decarboxylated and deiodinated metabolites of thyroid hormones (THs). Of all possible thyronamine variants, only 3-iodothyronamine (3-T 1 AM...

...Rob Janssen; Alice Muller; Warner S. Simonides The heart is a principal target of thyroid hormone, and a reduction of cardiac thyroid hormone signaling is thought to play a role in pathological ventricular remodeling and the development of heart failure. Studies in various rodent models of heart...

... function Thyroxine Thyroid tests Thyroid hormone Surgery Obesity Thyroid hormone affects metabolism in virtually every organ system. Several studies have indicated that thyroid hormone also influences the hemostatic balance and that these changes are associated with a risk of venous...

...Maik Pietzner; Georg Homuth; Kathrin Budde; Ina Lehmphul; Uwe Völker; Henry Völzke; Matthias Nauck; Josef Köhrle; Nele Friedrich Context: 3,5-Diiodo-<smlcap>L</smlcap>-thyronine (3,5-T 2 ) is a thyroid hormone metabolite which exhibited versatile effects in rodent models, including...

... decreased triiodothyronine (T 3 ) concentrations to be associated with postoperative atrial fibrillation (POAF). Therapy with thyroid hormones (TH), however, did not reduce the risk of POAF. This study reevaluates the relation between thyroid hormone status, atrial electromechanical function and POAF...

...Eva K. Wirth; Eddy Rijntjes; Franziska Meyer; Josef Köhrle; Ulrich Schweizer Background: The Allan-Herndon-Dudley syndrome is a severe psychomotor retardation accompanied by specific changes in circulating thyroid hormone levels (high T 3 , low T 4 ). These are caused by mutations in the thyroid...

...Ulrich Schweizer; Jörg Johannes; Dorothea Bayer; Doreen Braun Thyroid hormones (TH) cross the plasma membrane with the help of transporter proteins. As charged amino acid derivatives, TH cannot simply diffuse across a lipid bilayer membrane, despite their notorious hydrophobicity...

...Tina Toft Kristensen; Jacob Larsen; Palle Lyngsie Pedersen; Anne-Dorthe Feldthusen; Christina Ellervik; Søren Jelstrup; Jan Kvetny Background: The significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after hemithyroidectomy...

...Graham R. Williams Thyroid hormones exert widespread and complex actions in almost all tissues during development, throughout childhood and in adults. The skeleton is an important T3-target tissue that exemplifies these processes, and yet understanding of the specific cellular and molecular...

... is shown including the 18-amino-acid loop that controls D2 half-life [101] and contains the Thr92Ala polymorphism. Modified from Callebaut et al. [102]. Fig. 1 Major aspects of thyroid hormone economy in healthy human subjects. The human thyroid produces approximately 90 µg of T 4 and 5 µg of T 3...